ID I3J6X4_ORENI Unreviewed; 1125 AA.
AC I3J6X4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Par-3 family cell polarity regulator {ECO:0000313|Ensembl:ENSONIP00000004614.2};
GN Name=pard3 {ECO:0000313|Ensembl:ENSONIP00000004614.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004614.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004614.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endomembrane system
CC {ECO:0000256|ARBA:ARBA00004308}.
CC -!- SIMILARITY: Belongs to the PAR3 family.
CC {ECO:0000256|ARBA:ARBA00005358}.
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DR AlphaFoldDB; I3J6X4; -.
DR Ensembl; ENSONIT00000004617.2; ENSONIP00000004614.2; ENSONIG00000003668.2.
DR eggNOG; KOG3528; Eukaryota.
DR GeneTree; ENSGT00950000183214; -.
DR HOGENOM; CLU_006629_1_0_1; -.
DR TreeFam; TF323729; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0005923; C:bicellular tight junction; IEA:UniProtKB-SubCell.
DR GO; GO:0012505; C:endomembrane system; IEA:UniProtKB-SubCell.
DR CDD; cd00992; PDZ_signaling; 3.
DR Gene3D; 2.30.42.10; -; 3.
DR InterPro; IPR021922; Par3/HAL_N.
DR InterPro; IPR001478; PDZ.
DR InterPro; IPR036034; PDZ_sf.
DR PANTHER; PTHR16484:SF18; PARTITIONING DEFECTIVE 3 HOMOLOG; 1.
DR PANTHER; PTHR16484; PARTITIONING DEFECTIVE 3 RELATED; 1.
DR Pfam; PF12053; Par3_HAL_N_term; 1.
DR Pfam; PF00595; PDZ; 3.
DR SMART; SM00228; PDZ; 3.
DR SUPFAM; SSF50156; PDZ domain-like; 3.
DR PROSITE; PS50106; PDZ; 3.
PE 3: Inferred from homology;
KW Cell junction {ECO:0000256|ARBA:ARBA00022427};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Tight junction {ECO:0000256|ARBA:ARBA00022427}.
FT DOMAIN 269..344
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 455..529
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT DOMAIN 570..645
FT /note="PDZ"
FT /evidence="ECO:0000259|PROSITE:PS50106"
FT REGION 80..104
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 142..278
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 382..444
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 735..799
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 888..1012
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 87..104
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 165..185
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 186..201
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 207..227
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 232..262
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 382..414
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 423..444
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 911..926
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 932..967
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 974..1012
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1125 AA; 124391 MW; 41154EF237547B6D CRC64;
MKVTVCFGRT RVVVPCGDGN VKVQSLIEQA AMRYKKAIAK DPSYWVQVNR LEHGDGGILD
QDDMLCDVVD DKDRLVAIYE EQDPHNGGDG TSASSTGTQS PEPFASEINS ASAFQPYQAN
SEIEVTPSAL LSNMSLNVRR SSDPALADFP PGEAPVAPEE PSRKNPARWS TTAGFQKPNH
KRNPSNETGS LERKGRGAHA YRSLPRDASG WSTQFQREMT RSSLSANHPM VDRWLDRQEQ
DEEEEQRRHE RRIERTEPVG RADSSLEHSP PVEVSNEGGP LGIHVVPFSS HDIRTQGLLV
KRLEPGGKAE QERLFQENDC IVRINQGDIR NLRFEQAQNI FKQAMRSPVI LFHVVPAAMK
KQYELLSAQN ELSSPPQLNR VRFSQESQQP ADRSSLTGGL TPRSGQQSDS SRRFATPPHI
LVSRTPSAPS PNLQRRISTN APSTTYLKNK GRRFNVQLKK GPEGLGFSIT SRDVPIGGSA
PIYVKNILPQ GAAIQDGRLK AGDRLLEVSG VDLNGKSQEE VVALLRATPM GGTVNLLVIR
PEDSLLPREV QEKDDIVLTP DGTQEFMTFE IPLNDSGSAG LGVSVKGNRS KENHADLGIF
VKSIINGGAA SKDGRLHVND QLIAVNGESL LEKTNQEAME TLRKSMSVEG NKRGMIQLIV
ARRVEVPGSP SFLEHPLNSI LESHERRISN SLYETTEGPD SVSTPRANTI GRIGRFQLSP
TVNMPQDDIV MIEDDRPPLL PPHLSDQSSS SSHDDMGFVG ENPVPWIHDS LSPDADPDTS
FQREGFGRQS MSEKRTKQYE NPAQLEIIKS RKSKSMDLVT LFNLSIGSAE QQFGPSLGLK
KSSSLESLQT AVAGTVQNGE INVRRSRSRI VRSRGCNESF RAAIDKSYEK PAVTAPEEEN
SVDTLDDDTS SRSGQESMST SGDLTLGPGL NGRDDRQKDQ EKSGMKEKKK PEREKDKDKD
KNKSKKGVLK GLFRFGKNRK DERPDDKMER RSSTKSKAED MQASEEETQQ MRLEQERIQA
KTRELREKQA KEREYAEIQD VVSRTFSSDE DHTYAGIGSL CSSIDSSTID PYSHPYHLPQ
NNGPPLEALY AQVNKPRNGR PAAPDSCHLG ACDLSLLGTG VRRMC
//
