ID I3J765_ORENI Unreviewed; 635 AA.
AC I3J765;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Cyclic nucleotide gated channel subunit alpha 3 {ECO:0000313|Ensembl:ENSONIP00000004705.2};
GN Name=CNGA3 {ECO:0000313|Ensembl:ENSONIP00000004705.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000004705.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000004705.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3J765; -.
DR Ensembl; ENSONIT00000004708.2; ENSONIP00000004705.2; ENSONIG00000003742.2.
DR eggNOG; KOG0500; Eukaryota.
DR GeneTree; ENSGT00940000158737; -.
DR InParanoid; I3J765; -.
DR OMA; YIGINNP; -.
DR TreeFam; TF319048; -.
DR Proteomes; UP000005207; Linkage group LG23.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005216; F:monoatomic ion channel activity; IEA:InterPro.
DR GO; GO:0050896; P:response to stimulus; IEA:UniProtKB-KW.
DR CDD; cd00038; CAP_ED; 1.
DR Gene3D; 1.10.287.70; -; 1.
DR Gene3D; 1.20.5.300; -; 1.
DR Gene3D; 1.10.287.630; Helix hairpin bin; 1.
DR Gene3D; 2.60.120.10; Jelly Rolls; 1.
DR InterPro; IPR032406; CLZ_dom.
DR InterPro; IPR018488; cNMP-bd_CS.
DR InterPro; IPR000595; cNMP-bd_dom.
DR InterPro; IPR018490; cNMP-bd_dom_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR014710; RmlC-like_jellyroll.
DR PANTHER; PTHR45638:SF6; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL ALPHA-3; 1.
DR PANTHER; PTHR45638; CYCLIC NUCLEOTIDE-GATED CATION CHANNEL SUBUNIT A; 1.
DR Pfam; PF16526; CLZ; 1.
DR Pfam; PF00027; cNMP_binding; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR SMART; SM00100; cNMP; 1.
DR SUPFAM; SSF51206; cAMP-binding domain-like; 1.
DR SUPFAM; SSF81324; Voltage-gated potassium channels; 1.
DR PROSITE; PS00888; CNMP_BINDING_1; 1.
DR PROSITE; PS00889; CNMP_BINDING_2; 1.
DR PROSITE; PS50042; CNMP_BINDING_3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Ligand-gated ion channel {ECO:0000256|ARBA:ARBA00023286};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Sensory transduction {ECO:0000256|ARBA:ARBA00022606};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 90..107
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 127..148
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 263..284
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 338..361
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 442..548
FT /note="Cyclic nucleotide-binding"
FT /evidence="ECO:0000259|PROSITE:PS50042"
FT COILED 582..634
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 635 AA; 73062 MW; 837C5694780F60D4 CRC64;
MAANFLLLNS DQTEVIVLGP ENLRNMVSNQ ILTLDGITLA SSNAVRNLGV IFDQDMSFNR
NSRHKRGTTV YTLSLQPGCR SAVTTTKIKL TLHFNLFLIK INTYFYLKGN FFSFRKEVWI
MDPATDMYYY WLLTIAVPVF YNLIFLVARA CFNELQYQNS TLWMVLDYVS DALYYIDIFV
RARTGFLEQG LLVKDAKILK EKYMKTPQFK LDMLSVIPTD IVFFHIGINN PEWRFNRLFR
LGRLFEFFDR TETRTNFPNI FRIANLVLYI IIIIHWNGCL YFAVSKILGF GSDTWVYPGP
AKPEFSQLTR QYIYCFYWST LTLTTIGETP PPVRDVEYFF VVVDFLTGVL IFATIVGNVG
AMISNMNAAR VEFQAKIDSI KQYMQFRKVT KDLEARVVKW FDYLWTEGKT CDEKQVLKNL
PDKLKAEIAI NVHLETLRKV RIFQDCEAGL LVELVLKLQP QVFSPGDYIC KKGDIGREMY
IIKEGKLAVV ADDGVTQFVV LSDGAYFGEI SILGIKGSKA GNRRTANIRS VGYSDLFALS
KDDLMEALTE YPDAKNALEE KGRAILMKDN LIDESLVAAT DAKDLEDKVD QIETSFEIMS
AKFRKLTNQY ESSQRKLKQR LSNLSNQFRS LRVDE
//
