ID I3J9E1_ORENI Unreviewed; 870 AA.
AC I3J9E1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE SubName: Full=Nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 {ECO:0000313|Ensembl:ENSONIP00000005481.2};
GN Name=NFKB1 {ECO:0000313|Ensembl:ENSONIP00000005481.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005481.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005481.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
CC Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR AlphaFoldDB; I3J9E1; -.
DR STRING; 8128.ENSONIP00000043478; -.
DR Ensembl; ENSONIT00000005485.2; ENSONIP00000005481.2; ENSONIG00000004349.2.
DR eggNOG; KOG0504; Eukaryota.
DR GeneTree; ENSGT00940000158625; -.
DR HOGENOM; CLU_004343_1_0_1; -.
DR TreeFam; TF325632; -.
DR Proteomes; UP000005207; Linkage group LG2.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-KW.
DR GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR GO; GO:0003677; F:DNA binding; IEA:UniProtKB-KW.
DR GO; GO:0003700; F:DNA-binding transcription factor activity; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd01177; IPT_NFkappaB; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR Gene3D; 1.10.533.10; Death Domain, Fas; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR Gene3D; 2.60.40.340; Rel homology domain (RHD), DNA-binding domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR011029; DEATH-like_dom_sf.
DR InterPro; IPR000488; Death_domain.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR033926; IPT_NFkappaB.
DR InterPro; IPR000451; NFkB/Dor.
DR InterPro; IPR008967; p53-like_TF_DNA-bd_sf.
DR InterPro; IPR030492; RHD_CS.
DR InterPro; IPR032397; RHD_dimer.
DR InterPro; IPR011539; RHD_DNA_bind_dom.
DR InterPro; IPR037059; RHD_DNA_bind_dom_sf.
DR PANTHER; PTHR24169:SF9; NUCLEAR FACTOR NF-KAPPA-B P105 SUBUNIT; 1.
DR PANTHER; PTHR24169; NUCLEAR FACTOR NF-KAPPA-B PROTEIN; 1.
DR Pfam; PF12796; Ank_2; 2.
DR Pfam; PF00531; Death; 1.
DR Pfam; PF16179; RHD_dimer; 1.
DR Pfam; PF00554; RHD_DNA_bind; 1.
DR PRINTS; PR00057; NFKBTNSCPFCT.
DR SMART; SM00248; ANK; 5.
DR SMART; SM00005; DEATH; 1.
DR SMART; SM00429; IPT; 1.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR SUPFAM; SSF47986; DEATH domain; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49417; p53-like transcription factors; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 3.
DR PROSITE; PS50088; ANK_REPEAT; 3.
DR PROSITE; PS01204; REL_1; 1.
DR PROSITE; PS50254; REL_2; 1.
PE 4: Predicted;
KW Activator {ECO:0000256|ARBA:ARBA00023159};
KW ANK repeat {ECO:0000256|ARBA:ARBA00023043, ECO:0000256|PROSITE-
KW ProRule:PRU00023}; Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW DNA-binding {ECO:0000256|ARBA:ARBA00023125};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transcription {ECO:0000256|ARBA:ARBA00023163};
KW Transcription regulation {ECO:0000256|ARBA:ARBA00023015}.
FT DOMAIN 43..251
FT /note="RHD"
FT /evidence="ECO:0000259|PROSITE:PS50254"
FT REPEAT 488..520
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 557..589
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 625..657
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REGION 664..687
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 664..684
FT /note="Acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 870 AA; 94667 MW; FB8E1402201B659C CRC64;
LAFFDHYYFM FLSLLQMFDN IMMDPTWEFP HFAMPQTTSL RTVDGPFLQI VEQPKQRGFR
FRYGCEGPSH GGLPGATSEK NRKTYPTVKI CNYQGQARVV VQLVTALTAV PHLHAHSLVG
KQCDKGICIA DLQSKDSTIS FPNLGILHVT KKNVAKTLEE RMIEAFKLGY NCGVSIHPDI
DSVQGEVRVP REVTEHHLSV IRNAAAMQAK EMDLSVVRLM FTAFLPDSDG GFSRRLEPVV
SEPIYDSKAP NASNLKIVRM DRTAGCVTGG EEVYLLCDKV QKDDIQVRFY EEDDSGLTWE
ALGDFSPTDV HRQFAIVFKT PKYRDQNLQK PTSVFVQLKR KSDNETSEPK PFTYHPQILD
KEEVQRKRQK TLPNFQDFSG HGGGSLYRGG GGGGGPAAGG GPGSTGYYQG FTTYNYGGGG
GGGGGFTTGY SAGLGGGGGG IKHVTPPFSL LSGLHLAVLH NQQEALKSLT QVVSALPGEE
VLNMRNHLYQ TPLHLAVITQ QKEAVEALLL AGADPTLTDR HGNTVLHLAA QHEGGGMIQF
LLQHRELREL LDQTNTAGLC AIHLAVLANQ LSSLRELLEG GANVEIQERS CGRTALHLAT
ETDNVSLAGC LLLEGNAKVD CCTFDGSTPL HIAAGRGSVK LTALLMAAGA DPRKENFEPL
FFREEDEEES CEKESEDEEE DEGYIPGTTP FSMAATLQVF DLLNGKEYEP KTPQTAFIPP
QGDLANLDTE VKQALCGTLE SEGCWENLAH SLGLGILNTA FRLSPSPAKT LLDSYEVSGG
TIRELLAALR SVGECRALSI LEEALHESEE APATNEMSGE HWTLESTAGS ATAGWSFPRH
NDLIGPPPAE SIHPPVVPRL ALDRVRRSSS
//
