ID I3J9G9_ORENI Unreviewed; 1923 AA.
AC I3J9G9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=DS cell adhesion molecule like 1 {ECO:0000313|Ensembl:ENSONIP00000005509.2};
GN Name=DSCAML1 {ECO:0000313|Ensembl:ENSONIP00000005509.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000005509.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000005509.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000005509; -.
DR Ensembl; ENSONIT00000005513.2; ENSONIP00000005509.2; ENSONIG00000004375.2.
DR eggNOG; KOG3510; Eukaryota.
DR GeneTree; ENSGT00940000155354; -.
DR HOGENOM; CLU_001038_0_1_1; -.
DR InParanoid; I3J9G9; -.
DR OMA; NFRWERN; -.
DR TreeFam; TF316846; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0007399; P:nervous system development; IEA:UniProtKB-KW.
DR CDD; cd00063; FN3; 5.
DR CDD; cd00096; Ig; 2.
DR CDD; cd05734; Ig_DSCAM; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 16.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR10075; BASIGIN RELATED; 1.
DR PANTHER; PTHR10075:SF72; DOWN SYNDROME CELL ADHESION MOLECULE-LIKE PROTEIN 1; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 5.
DR Pfam; PF13927; Ig_3; 3.
DR SMART; SM00060; FN3; 6.
DR SMART; SM00409; IG; 10.
DR SMART; SM00408; IGc2; 9.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 10.
DR PROSITE; PS50853; FN3; 6.
DR PROSITE; PS50835; IG_LIKE; 10.
PE 4: Predicted;
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Neurogenesis {ECO:0000256|ARBA:ARBA00022902};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 1589..1609
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 8..102
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 110..212
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 221..301
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 309..394
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 403..496
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 501..581
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 591..676
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 687..781
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 785..882
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 884..981
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 986..1085
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1090..1186
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1190..1284
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1286..1378
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 1380..1474
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 1479..1575
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1707..1797
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1833..1858
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1887..1908
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1717..1797
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1889..1908
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1923 AA; 211836 MW; 3E28DE7710C81C49 CRC64;
MMCCMFAPAV HSEDVGSTRL YFVNASLQRV TYSSSVGVSL PCPAGGTPSA ILRWYLATGD
DIYDVPHIRH VHANGTLQLY PFSPSAYNSY IHDNDYFCTA ENQAGKIRSP NIRIKAVFRE
PYTVRVADQR SMRGNVAVFK CLIPAAVQEY VSVVSWERDT VSIVPGNRFS LTSFGALYIS
DVQKEDALST YRCITKHKYS GETRQSNGAR LSVMDPNESA PTILDSFQAG EVYAGHSIEL
PCIAGGYPSP TVRWLKDGRP LPSDARWTRR LTGLTISDLR QEDSGSYACE VTNSFGSKEV
SGQLHVIDPL RVTLSPKNLK TGISSTLFFT CTVEGSPEYT ITWYRNTEPI VPDEHISIQG
QHNDTLQITA AQKLHSGAYQ CFASRKGHTA QDFSIILLED GTPRIVSSFS ERVVNPGEPF
SLMCAAKGAP PPSITWTLDD EPVVRDSTYK TSQYTLSDGL TVSHVNVSSP LIPDGGVYRC
VARNSAGSAE YQARINVRGP PRIRPMRDIT AVAGRNTYIT CRVIGYPYYS IKWLKDGMQL
PDNHRQVVFE NGTLRLTDVQ KGADEGTYLC SVLIQPQVSI NQTVHVTVKV PPLIQPFDIP
STSVGKLMYI ACVVSSGDMP IRITWHKDGQ LIVPGSASGV AIETKEFMSS LQISNVTLKH
NGNYTCIASN AAATVSWERQ LIVTVPPRFV VQPNNQDCIY GKAGVLNCSV EGYPPPKVMW
KHAKGVGNPQ QYHPVPLTGR IQIMSNGSLL IRHVLEDDRG YYLCQASNGV GSDISKSMIL
TVKIPAMITS HPNTTMARKG QIKELNCTAR GEQPIIIRWE RGDTVIDAER NPRYSISINK
KGDEVISTLK LNPAERGDSV FFSCHAINSY GEGRGLIQLT VQEPPDPPEL EVREVKDRSM
NLRWIQRFDG NSIITSYDIE YKNKSDTWDH MYTTRNISPT NNQANIVELH PACVYSIRMY
SYNKIGRSLP SKELTISTEE APPDGPPMDV ILQPMTSQSI RVTWRAPKKE LQNGVIRGYQ
IGYRENGPGS NGQYSIVEMK ATGDSEVYTL DNLKKFAQYG VVVQAFNRAG TGPSSTEINA
TTLEDVPSEP PQNVRAISVT SDEAVITWAE PPRLTLHGVL KGYRVVFWSL FPDGEWGEMQ
NITTTREQVE LRGLEKFTNY SVQVLAYTQA GDGVRSNVLY IQTREDLPGP PAGIKAVPSS
SSSVVVSWLP PLKPNGIIRK YTIYCSSPGS GQPAPSEYEA NPEMLFYRIT HLTRGKQYLI
WAAAVTTAGR GNISAKVTVE PAGKVPAKIL SFGGTVTTPW MKEVRLPCSS VGEPTPTIKW
TKDSEDSAIP VTADSQRQIL SNGTLVLRLV KAEDSGYYTC TATNTLGFDT IIVNLVVQVP
PDQPRLTVST TSTSSITLAW IPGDNGGSSI RGFVLQYSVD NTEEWRDVFI SSSERSFRLD
NLRCGTWYKV KLAAKNSVGS GRISEIIEAK THGREPVFNK DQPLLTHINS THAGLNLQGW
TSGGCPITDL MLDFRPKGTW AWQSLKANST NQLFLSELRE ATWYELKMKA CNSAGCGNQT
SQFATTDYDG STIPPIKSAR GEGDDVKKLF SIGSPVILVT LGVALLFIIR KKRKEKRLKR
LRDAKSLAEM LISKNNRSID TPVKGPPQGP RLHIDIPRVQ LLIEDKEEDK AAVPVTDTEF
SQSVNPQNFC TGVSLHHQAL IQNSGPLIDM SDIRPGTNPV SRKSIKSAHS SRNRYSSQWT
LSRPSQSQST ASARTLTSDW RTMGSHGITA TESDSYSASL SQDTDKGRNS MVSTESASST
YEELARAYEH AKLEEHLQHA KFTITECFIS DSSSDQMTTG TNDPADSMTS LSTPSEPGIC
RFTASPPKPQ DYDRGKNVAV PIPHRANKSK YQRTLTMPKS SSSALGRLQK QSVGAYSKSY
TLV
//
