ID I3JC08_ORENI Unreviewed; 899 AA.
AC I3JC08;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 72.
DE SubName: Full=Rho GTPase activating protein 9 {ECO:0000313|Ensembl:ENSONIP00000006398.2};
GN Name=ARHGAP9 {ECO:0000313|Ensembl:ENSONIP00000006398.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006398.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006398.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_013130950.1; XM_013275496.2.
DR AlphaFoldDB; I3JC08; -.
DR STRING; 8128.ENSONIP00000006398; -.
DR Ensembl; ENSONIT00000006403.2; ENSONIP00000006398.2; ENSONIG00000005088.2.
DR GeneID; 100697172; -.
DR CTD; 64333; -.
DR eggNOG; KOG1450; Eukaryota.
DR GeneTree; ENSGT00950000182860; -.
DR HOGENOM; CLU_015883_6_1_1; -.
DR InParanoid; I3JC08; -.
DR OMA; ELRAWHH; -.
DR OrthoDB; 5395569at2759; -.
DR TreeFam; TF329345; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005096; F:GTPase activator activity; IEA:UniProtKB-KW.
DR GO; GO:0005543; F:phospholipid binding; IEA:InterPro.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd13233; PH_ARHGAP9-like; 1.
DR CDD; cd04403; RhoGAP_ARHGAP27_15_12_9; 1.
DR CDD; cd12143; SH3_ARHGAP9; 1.
DR CDD; cd00201; WW; 1.
DR Gene3D; 2.20.70.10; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR035465; ARHGAP9_SH3.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001605; PH_dom-spectrin-type.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR001202; WW_dom.
DR InterPro; IPR036020; WW_dom_sf.
DR PANTHER; PTHR23176:SF103; RHO GTPASE-ACTIVATING PROTEIN 9; 1.
DR PANTHER; PTHR23176; RHO/RAC/CDC GTPASE-ACTIVATING PROTEIN; 1.
DR Pfam; PF00169; PH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00397; WW; 1.
DR PRINTS; PR00683; SPECTRINPH.
DR SMART; SM00233; PH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SMART; SM00456; WW; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR SUPFAM; SSF51045; WW domain; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
DR PROSITE; PS50020; WW_DOMAIN_2; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW GTPase activation {ECO:0000256|ARBA:ARBA00022468};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 33..99
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT DOMAIN 320..348
FT /note="WW"
FT /evidence="ECO:0000259|PROSITE:PS50020"
FT DOMAIN 491..603
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 686..893
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT REGION 191..230
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 291..313
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 342..366
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 627..652
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 899 AA; 100882 MW; 062774ACC5453719 CRC64;
MLSGSWRRSF GHQQPAAGSV VNTRGMTVCG VPSGTVVLEA QYDYSYRGAD GRQVCIREGE
RFILLKKTNA DWWQVRRIGA ASKAKPLYVP ATYVTEVPIA PMPSPQRLTA TASLNTNFRI
LPRVSLSPSP TGATNNEQRQ VNKLLYHSME NLNSNSAFQG LKNNTSVDRG HFPTLPLSGF
TFASNSPTSS SGHLMVPGSQ ATSTAQTAPT NPRVVPTITR SQSSNNLPEN LMENPYDEVG
GGFSSRTNHR IPKKSCSQWD VAGASGKNNH LQVPTESYLS QLSWQDSPLY TEKQTEKRQS
QPEPPSPAPG EQPLQILGLW EQYSDATTGR WYYVNSITKE RSWKPPRRAR GQFTNQAGPG
QPQTLPRDTS HLSLSLTAAG NGTTHRLSPD FLFGSHQRNP DNGWQMKKSM QRAASSDTLS
TMAFSDTRTQ CHDSAPQHDV KQQLNHSQSM ILPDNGKLVQ QCRDYSCNVT NIVVEPPSPA
SSPDSDGCTP ELEKAGLLNK TKIAEGGRKL RKNWSPSWVV LVGNSLVFFK DPKSQTPSSW
KPGNSRPESS VDLRGAKLHW ANELSSKKNV FKLRTVTGNE FLLQSETDSL IREWYSTIQN
VIDRLDRENP LDNVLLYSLR RAGSVEMLDQ SGDEDDRRPS LPRSTSNLEN TERKRVKTRL
KKLILKRPPL QALQEKGLIK DQVFGCSLEM LCERERSTVP RFVRLCTEAV ERRGLETDGI
YRVSGNLAVI QKLRFLVNHE RAVTTDGRYM FPAELVQEEK LNLDESEWED IHVITGALKL
FFRELPEPLV PYGFFTDIVE TVKMSDYMDK IDRLKCLVLN MPPPNHDTLQ FMCRHLKRVL
EHSETNRMTT QNIGIVFGPT LMRPERDNGN MAVNMVYQNQ AVELILTEFD HIFGTRGPS
//
