ID I3JD10_ORENI Unreviewed; 394 AA.
AC I3JD10;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=G-protein coupled receptor family C group 5 member C {ECO:0000313|Ensembl:ENSONIP00000006750.1};
GN Name=GPRC5C {ECO:0000313|Ensembl:ENSONIP00000006750.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000006750.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000006750.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR RefSeq; XP_005455003.1; XM_005454946.3.
DR RefSeq; XP_019213433.1; XM_019357888.1.
DR AlphaFoldDB; I3JD10; -.
DR Ensembl; ENSONIT00000006755.2; ENSONIP00000006750.1; ENSONIG00000005368.2.
DR GeneID; 100712211; -.
DR KEGG; onl:100712211; -.
DR eggNOG; ENOG502QQEH; Eukaryota.
DR GeneTree; ENSGT00950000182961; -.
DR OrthoDB; 4263681at2759; -.
DR TreeFam; TF321410; -.
DR Proteomes; UP000005207; Linkage group LG4.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR InterPro; IPR017978; GPCR_3_C.
DR PANTHER; PTHR14511; G PROTEIN COUPLED RECEPTOR, CLASS C, GROUP 5; 1.
DR PANTHER; PTHR14511:SF15; G-PROTEIN COUPLED RECEPTOR FAMILY C GROUP 5 MEMBER C; 1.
DR Pfam; PF00003; 7tm_3; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 26..54
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 66..88
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 100..123
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 135..160
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 180..202
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 214..237
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 249..268
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 22..270
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|Pfam:PF00003"
SQ SEQUENCE 394 AA; 43037 MW; CDAF2775CC62875F CRC64;
MGPTSAPKGC GGDVSSIYYN LCDLTAVWGI VVEAVAAVGV LTAFILFVIL MASLPFVTDK
KRKGMVGLQA SILVFTLGLF GLSFAFIVEQ YSTTCAARRY LFGVLFTGCL ACLVMHGLWL
ALLQRGGRGP RSWMLWLGAL ALWLVEVIIN TEWLVITVAR SPLRDLSVPD LACSIVSRDF
VMALIYVMVL IAAVVLTSVP SLTHKQKHWR RDGTFILVTG VLTLALWIAW IVMYIHGNQA
VGNPSWDDPT LAIAVVSNAW VFLFFYAIPE ICLLTQEDPN KEQPDGEEVY PARSLVYDNI
LKEPQPTQQH VYIENKAFSM DEPESTNPAS PYGAYNGQAR SCLYQPTEIA LIAKGLTRKD
QDSVILRTIP APLNMGSCSS GSCSVDSLTS SGLS
//
