ID   I3JED2_ORENI            Unreviewed;       853 AA.
AC   I3JED2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 68.
DE   SubName: Full=Transient receptor potential cation channel subfamily C member 6 {ECO:0000313|Ensembl:ENSONIP00000007223.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007223.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000007223.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC       pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
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DR   AlphaFoldDB; I3JED2; -.
DR   Ensembl; ENSONIT00000007228.2; ENSONIP00000007223.2; ENSONIG00000005731.2.
DR   GeneTree; ENSGT01060000248588; -.
DR   Proteomes; UP000005207; Linkage group LG14.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR   GO; GO:0005262; F:calcium channel activity; IEA:InterPro.
DR   Gene3D; 1.10.287.70; -; 1.
DR   Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR   InterPro; IPR002110; Ankyrin_rpt.
DR   InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR   InterPro; IPR005821; Ion_trans_dom.
DR   InterPro; IPR013555; TRP_dom.
DR   InterPro; IPR002153; TRPC_channel.
DR   NCBIfam; TIGR00870; trp; 1.
DR   PANTHER; PTHR10117:SF7; SHORT TRANSIENT RECEPTOR POTENTIAL CHANNEL 6; 1.
DR   PANTHER; PTHR10117; TRANSIENT RECEPTOR POTENTIAL CHANNEL; 1.
DR   Pfam; PF12796; Ank_2; 1.
DR   Pfam; PF00520; Ion_trans; 1.
DR   Pfam; PF08344; TRP_2; 1.
DR   PRINTS; PR01097; TRNSRECEPTRP.
DR   SMART; SM00248; ANK; 3.
DR   SMART; SM01420; TRP_2; 1.
DR   SUPFAM; SSF48403; Ankyrin repeat; 1.
PE   4: Predicted;
KW   ANK repeat {ECO:0000256|ARBA:ARBA00023043};
KW   Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW   Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW   ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT   TRANSMEM        359..379
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        391..414
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        480..504
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        547..564
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        584..607
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   TRANSMEM        655..677
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          204..266
FT                   /note="Transient receptor ion channel"
FT                   /evidence="ECO:0000259|SMART:SM01420"
SQ   SEQUENCE   853 AA;  98312 MW;  1BD0E0A233F2E489 CRC64;
     MTKIHLPVFR WSNEEKATML RQVVVKPRRQ AFWGAGYPFH PHSSSCLSMK EEVFLEAAEY
     GNIPEVRRML EELPDLNVNC VNYMGQNALQ LAVANEHLEL TRLLLKKKDL ARIGDALLLA
     ISKGYIRIVE AILSHEAFAD GQRLTNSPSQ AEMHDDFFSY DEDGTRFSHD ITPIILASQC
     QEYEIVHILL LKGARIERPH DYYCQCKTCS EQRRHDSFSH SQSRINAYKG LASPAYLCLS
     SEDPVMAALE LSNELAVLAN TEKEFKNDYK NLSMQCKDFV VGLLDLCRNT EEVEAILNGD
     KESYRSSDTT NRQNLIRLKL AIKYEVKKFV AHPNCQQQLL SIWYENLSRL HQQTTAVKIL
     LVLGVALGLP ILAFIYWIAP SSKLGKLMGG PFLKFVAHAA SFMIFLCLLV LNAADRFEGT
     SLLPNMTIHD YPSQLFRMKT TPFTWMEILI ISWIIGKIWE ECNNIWSQDI REYISEPWNL
     LDFSILTIFM TSFTARLMAF WHAYSAQCYI DKHHTSLSNM TLPFEIQYFQ LARIHWMPSD
     PQLISEGLYA IAVVLSFSRI AYILPANESF GPLQISLGRT VKDIFKFMVV FVTVFVAFMV
     GMFNLYSYYL GAKHNNAFTT LEESFKTLFW AIFGLSEVKS VVIDINHKFI ENVGYVLYGV
     YNIIMVVVLL NMLIAMFNSS FQEIEDDADV EWKFARAKLW FSYFDHSGTL PVPFNLVPSP
     KSVSCLLLSI KDFIWNVPPG RHKRNSRNEM EEIIGRAEQN YNHDFVTLLQ KIMNCLIKRY
     ILKAQRDKDN DEVNEGELKD IKHDISSLRF ELLEREKHDK KTLTELMGQL EEVMHVKQKE
     EKICLIVSVA TLN
//