ID I3JEF7_ORENI Unreviewed; 1084 AA.
AC I3JEF7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=Protogenin {ECO:0000313|Ensembl:ENSONIP00000007248.2};
GN Name=PRTG {ECO:0000313|Ensembl:ENSONIP00000007248.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007248.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007248.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3JEF7; -.
DR Ensembl; ENSONIT00000007253.2; ENSONIP00000007248.2; ENSONIG00000005750.2.
DR GeneTree; ENSGT00940000155943; -.
DR HOGENOM; CLU_006906_1_0_1; -.
DR Proteomes; UP000005207; Linkage group LG1.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR CDD; cd00063; FN3; 5.
DR Gene3D; 2.60.40.10; Immunoglobulins; 9.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF47; PROTOGENIN; 1.
DR Pfam; PF00041; fn3; 5.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 1.
DR SMART; SM00060; FN3; 5.
DR SMART; SM00409; IG; 4.
DR SMART; SM00408; IGc2; 4.
DR SUPFAM; SSF49265; Fibronectin type III; 3.
DR SUPFAM; SSF48726; Immunoglobulin; 4.
DR PROSITE; PS50853; FN3; 5.
DR PROSITE; PS50835; IG_LIKE; 4.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 928..950
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 957..974
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 37..113
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 118..205
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 218..305
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 310..389
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 404..498
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 500..596
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 601..700
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 707..800
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 805..900
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 1021..1084
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1021..1053
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1062..1084
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1084 AA; 120521 MW; 7ACB06826387FB82 CRC64;
QSFFFLDIYI FISYSVLSFS ELFFIKEPLD VTVIRKEAAI LDCQARGEAP IDVRWLKSGV
QIAENERVYL LSNGSLFISE VESRRGDKSD EGFYQCLAQN KYGAILSQKA HLTIASISSF
SVQPTSIVAT EGSVARFSCK IVAHPPPIIT WEFNRVTLPL ATERITVLPS GVLQIQGVQQ
ADAGNYRCIA TNISSRRRST EATLTVTPGP RPQLPQRPRI IASPQNISVS LHQTAILECM
ATGNPRPIIS WSRADSKPID VYNTKVLGNG NLIITDIKPQ HGGVYLCRAT TPGTRNYTMA
SANVTVLAPP SLVEWPESLT RPRAGTARFV CHAEGNPTPR ITWLKNGEKV HSNGRIKMYN
SKLVINQIIP EDDAIYQCQA ENEQGSVLTM ARLIVVMSED RPSAPRNIRA DTVSSSAILL
AWERPLYNSD KVIAYSVHYM KAEGLNNEEY QIVIGNDTTR YIIDDLEPAH NYTFYVVAYM
PMGASRMSDN VFQHTLEDVP LRAPELSLTS RSPTDIQVSW QPLPDKLSRG RVCSYRLSYR
TSSDSAVSQI ELPGEKTQHL LENLQPDTIY LLRIVAATSV GWGEQSAWTS HRTPKASGAQ
VPLAPELHLE SLNCTTILVR WQLAPRNSAS VRGYKLFYHE ESQPESTPVQ FHASDNKHTI
GGLDPRKKYH VKILAYNVVG DGYQADQTIS TPGCVSVRDR LVPPPPPPHN VYAKTNSSTA
VFLHWGRPAF TSSHTVNYTV RCNPVGLQNA SLVLYLQTSE QSLHVRDLEP NTKYEFAVRL
HLDQLSSPWS PVVYQSTFPK APMRPPSNIK VTLIEEDTAL VSWKLPDELN VPVTRYTILY
ASRNDWIAGE WQVMEREGTI TMALLENLKP GQVYFVKVSA SNDMGDGPFS HAVELTVQED
LPLGHDLRVS RGSTTFSDSF YHLDQKSMTG ISVGVCIALI CIIICAFIII CRGKNRYLVS
LSIPLLLLLF LQGGTELIIN SLGPVQHTAE RKRKWFSFSS DVKKETKPTQ HGTTVLTYEE
ELSPNQPTNL QTLLGRPGDT EGSSNSEGSH ATGDSGRYSH DETELTNLSS GPSKLRNRHT
HTPL
//
