ID I3JFL5_ORENI Unreviewed; 2007 AA.
AC I3JFL5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 74.
DE SubName: Full=Dedicator of cytokinesis 10 {ECO:0000313|Ensembl:ENSONIP00000007656.2};
GN Name=DOCK10 {ECO:0000313|Ensembl:ENSONIP00000007656.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000007656.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000007656.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the DOCK family. {ECO:0000256|PROSITE-
CC ProRule:PRU00983}.
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DR STRING; 8128.ENSONIP00000058991; -.
DR Ensembl; ENSONIT00000007661.2; ENSONIP00000007656.2; ENSONIG00000006078.2.
DR eggNOG; KOG1997; Eukaryota.
DR GeneTree; ENSGT00940000157469; -.
DR HOGENOM; CLU_000624_1_0_1; -.
DR TreeFam; TF313629; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005085; F:guanyl-nucleotide exchange factor activity; IEA:UniProtKB-KW.
DR GO; GO:0007264; P:small GTPase mediated signal transduction; IEA:InterPro.
DR CDD; cd08697; C2_Dock-D; 1.
DR CDD; cd13267; PH_DOCK-D; 1.
DR Gene3D; 1.20.58.740; -; 1.
DR Gene3D; 1.25.40.410; -; 1.
DR Gene3D; 2.60.40.150; C2 domain; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR037809; C2_Dock-D.
DR InterPro; IPR027007; C2_DOCK-type_domain.
DR InterPro; IPR035892; C2_domain_sf.
DR InterPro; IPR026791; DOCK.
DR InterPro; IPR021816; DOCK_C/D_N.
DR InterPro; IPR043161; DOCK_C_lobe_A.
DR InterPro; IPR043162; DOCK_C_lobe_C.
DR InterPro; IPR027357; DOCKER_dom.
DR InterPro; IPR046769; DOCKER_Lobe_A.
DR InterPro; IPR046770; DOCKER_Lobe_B.
DR InterPro; IPR046773; DOCKER_Lobe_C.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR23317; DEDICATOR OF CYTOKINESIS DOCK; 1.
DR PANTHER; PTHR23317:SF71; DEDICATOR OF CYTOKINESIS PROTEIN 10; 1.
DR Pfam; PF06920; DHR-2_Lobe_A; 1.
DR Pfam; PF20422; DHR-2_Lobe_B; 1.
DR Pfam; PF20421; DHR-2_Lobe_C; 1.
DR Pfam; PF14429; DOCK-C2; 1.
DR Pfam; PF11878; DOCK_C-D_N; 1.
DR Pfam; PF00169; PH; 1.
DR SMART; SM00233; PH; 1.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR PROSITE; PS51650; C2_DOCK; 1.
DR PROSITE; PS51651; DOCKER; 1.
DR PROSITE; PS50003; PH_DOMAIN; 1.
PE 3: Inferred from homology;
KW Guanine-nucleotide releasing factor {ECO:0000256|ARBA:ARBA00022658};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 120..229
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 588..765
FT /note="C2 DOCK-type"
FT /evidence="ECO:0000259|PROSITE:PS51650"
FT DOMAIN 1567..1994
FT /note="DOCKER"
FT /evidence="ECO:0000259|PROSITE:PS51651"
FT REGION 232..291
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 365..384
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1188..1208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1282..1312
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 240..266
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1188..1203
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1282..1303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2007 AA; 228420 MW; 66D411CCB92EF10B CRC64;
EYEKPKVIDP LDYETVISEL GDECKEDPLR DLLLFPDNDF SSFSRFVGIF HCQRAIFFLH
HLPDLSLFPF RKLYKAEKLP SHSFEIDYED VDKDEDTTSL SSSKGGGGGG GGGGGGGGIG
VFRSGWLYKG NFNSTVNNSI TVRSFKRRYF QLTQLTDNSY IMNFYKDEKI SKEPKGCIFL
DSCTGVVQNN RLRKHAFELK MNEVTYFVLA AESEQDMEEW ISTLTRILQI SPPEAPAQDR
KSLELNEHRQ DEGIRSARRE ERLNLFSLDP DTPALRSPRS EHSSTESTPV RPFEEKLGRR
FMATCRSFNL MLQGCVNESE TGPVTNIEPF FVSLALLDVR EGRKVSADFH VDLNHEAVRQ
MLGGLSNGTG APDTEVGGQE NGLCSPAERK PGDCYLSLDL EHWLCFPKQA IFSVTNPHTD
IVMVARVEKV LMGNIACGTE AYTKNTDSSK TVQKILKSNK QFCSKLGKYR MPFAWSVRSV
FKDNHGALDR ESRFSPLFKQ ESNKISTDDL IKLVSEYRRA EKTSKLQTIP GTLDIALDYV
PMEHPNCVTS SYIPVKPFED LTKHQPTVEV EEFAQDATKF IQPHRVYKNH IYVYPKHLKY
DSQKSFAKAR NLSVYVEFRS SDEEVEKPLK CIYGKPGGPV FTTTACSTVL HHSQSPDFYD
EVKIELPTQL HEKHHLLFSF YHVTCDINAK TNSKRKETLE TPVGYSWLPL LKEGRVSTQE
FNIPVSCNLP PGYLAIKEAS NTKNGADVKW VDGGKPIFKV STNVISTVYT QDPHLNRFFQ
QCQKRELDLS IPPTSNFLNC LKGLLSMEKI PVIVRFLPVL FNQLFKVLTQ NDNDEVTTAT
TRVLVHIVAK CHEENLDSSL HSYIKYVFKS EDHGFRTVHE ELAKGMTFDL KSNEQAAVKN
VLKFSWFFFE LIVKSMAQHL VDYDKLKLPR PQRFPSSYQS RVENLVETVS EHIFWKNKEM
PEETRSANLA VAAFVKRCFT LMDRGFTFKL ISNYINMITV LCELKFEFLR EVCNHEHYIP
LSLPLPSARI TGKVAPQVIP SVPEYNLTGE FCRKHFLTGL LLRELGLALQ DEQDLRHLAL
ATLKTLMAKH SLDARYEKQA RIASLYLPLY GLILDNMPRF FLRDLFPIYF TTSDQGSRDD
LSVGAVVAGV VTRHANSVDA SFSKEVLNSI TAFSSLAVAT GNQADSRGSL ISVDSNPSNS
DRNSEKMDGC EKFARPQSLI GYGSRCDKLD QAETRSLLMC FLQIMKTISE GNIYHLKNSR
SPQEIYYIYS AAVKLAQSTH TNGTLKGSNN PSQSSQPSSL FPQWMASGGD GHRHARSQTM
PIIRGKNALT NPKLLQLMEP GNKYSEDGDT LSPTDVEANM STEVALTVLD VLELFVQHQK
QLLQDDGQNT LMKKVLDTYL LFFQINQSTA TLRHVFAALR LFVQKFPSAF FQGKADLCGC
LCYEILKCCN HRSSSTQTEA AALLYFFMRK NFEFTKGKSI VRSHLQVIKA VSQLIADAGI
GGSRFQQSLA IINNFANGDA PLKNTSFPAE VKDLTKRIRT VLMATAQMKE HEKDPEMLVD
LQYSLANSYA STPELRRTWL ESMAKIHVRN GDLSEAAMCY IHISALIAES LKRRASFSMG
WAAFMCISPN VKEEGAMKED TGTQDTPYTE DTLVEQLELC VDYLWKSERY ELIADINKPV
IAVFEKRRDF KRLSELYYDI HRSYLKVTEV VNSEKRLFGR YYRVAFYGQG FFEEEESKEF
IYKEPKLTGL SEISQRLLKL YSDKFGAENV KMIQDSNKVN PKELDPKFAY IQVTYVVPYF
DEKEQCDKRT DFERHHNINR FVFETPFTLS GKKHGDVEEQ CKRRTILTTS SSFPYLKKRI
QVVEQQSTEM NPIEVAIDEM SHKVSELNQL CNMEEVDMIR LQLKLQGSVS VKVNAGPMAY
ARAFLEEKNA KKYPDNQVKL LKEIFRRFAE ACGQALDVNE RLIKEDQLEY QEEMRAHYRD
MLTELSGIMN EQVSQCTAPT ERPVDSP
//