ID I3JGP2_ORENI Unreviewed; 1177 AA.
AC I3JGP2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Integrin, alpha 10 {ECO:0000313|Ensembl:ENSONIP00000008033.2};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSONIP00000008033.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008033.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008033.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; I3JGP2; -.
DR Ensembl; ENSONIT00000008038.2; ENSONIP00000008033.2; ENSONIG00000006374.2.
DR eggNOG; KOG3637; Eukaryota.
DR GeneTree; ENSGT00940000158423; -.
DR HOGENOM; CLU_004111_2_0_1; -.
DR TreeFam; TF105391; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 1.20.5.930; Bicelle-embedded integrin alpha(iib) transmembrane segment; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 2.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU003762};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692,
KW ECO:0000256|RuleBase:RU003762};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|RuleBase:RU003762}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 19..1177
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5025714699"
FT TRANSMEM 1102..1125
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT TRANSMEM 1145..1164
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT REPEAT 78..139
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 220..403
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 525..587
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 588..646
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 650..710
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1177 AA; 131723 MW; 3DB1E82C0D1C5038 CRC64;
MNSCLSIVLA LQQIGTQAVP HLSPYNSDTL QLQVEEDGWM LKSYGFNTFT IPPFSPVTVC
MLKQIYYLTN WLLCQCFNID VKHPRIFTGP EDALFGFSVL QHEADGEKSM LVGAPWDGPP
NNRKGDVYKC SVGREKNSSC NKVNLGETAL QNVSKNLRNS HLGMTLTPTS PDGFLACAPL
WSQECGTSMF STGICASVSD DLEPRETIAP TAQRCSTYMD IVIVLDGSNS IYPWYEVQNF
LSNILSKFHI SSDQMQVGIL QYGEVAIHEW SLKDYQTTQE VVEAAKNISR QEGRETRTAY
AIETACTEAF SPERGAREGA TKVMIVVTDG ESHDGDELEG ALEKCKERNI TRYAIAVLGH
YIRRQQDPET FIKEIKFIAS DPDDKYFFNV TDEAALNDIV DALGDRIFTL EGTLGYNESS
FHMEMSQIGF STHTLDDGIL FGMVGAYDWD GGVLKEGTNG RIVPSREAFE SEFPLELKNH
AAYLGYTVTS VVTGDWKRVY VAGAPRFKHK GKVILFELSD EGDVNIVQAL NGEQIGSYFG
SEVCGLDIDQ DDITDVLLVA APMYLGSGNK EAGRVYIYTL NRDVFVSNGT LKSNNKSQDA
RFGYALAPTP DLNHDGFTDL LVGAPLEDEH RGAIYVYHGD GIYVIHNYKQ RIAASSVSPS
LQYFGRSLSA RLDLDGDDLI DLAVGAQGSA VLLSSRSIVQ INVSLSFQPH SINVIQKTCH
RGGRESACLN ATACFTAVSR SPRPHNLWVR AMLDDRKLSA RALFDDSSHR QTQLAVRAQT
GKTLCYKLPF HVYDTADYIR PISFSLWFKI NNTESGPVLD EGWPTTINKS IPFFKDCGED
DVCTTDLVLQ AHMDISGTRQ KPYVIRSPRR RLAVEVQLQN RLENAYNTSL TLNYSRNLHF
SSISIREVAH FKIECTALSA NSHSCNVSYP VFRSQSKVNF MLEFEFSCTS LHNQVKMKLH
ASSDSVERQD TLKDNSVQLQ TFVQYEPDLF VSSESNLNRY EVHPTRTMSE AIGPEFYTHL
RLQNLGCYSV SNLELRLHLP SVAAGDRVFM TVTDVFSINV STASVYSYYA LRSYLTYVNY
TVGDGELQRT VLEVLKGRAI PISLWILIGS IIGGLLLLAL IIFILWKVFG TEISHQIPSR
KYQKVVNLSQ FLVFCLFFYQ LGFFTRKQIE EDENHED
//
