ID I3JGP3_ORENI Unreviewed; 1192 AA.
AC I3JGP3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Integrin, alpha 10 {ECO:0000313|Ensembl:ENSONIP00000008034.2};
GN Name=ITGA10 {ECO:0000313|Ensembl:ENSONIP00000008034.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008034.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008034.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479,
CC ECO:0000256|RuleBase:RU003762}; Single-pass type I membrane protein
CC {ECO:0000256|ARBA:ARBA00004479, ECO:0000256|RuleBase:RU003762}.
CC -!- SIMILARITY: Belongs to the integrin alpha chain family.
CC {ECO:0000256|ARBA:ARBA00008054, ECO:0000256|RuleBase:RU003762}.
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DR AlphaFoldDB; I3JGP3; -.
DR STRING; 8128.ENSONIP00000008034; -.
DR Ensembl; ENSONIT00000008039.2; ENSONIP00000008034.2; ENSONIG00000006374.2.
DR GeneTree; ENSGT00940000158423; -.
DR InParanoid; I3JGP3; -.
DR OMA; SRNITRY; -.
DR Proteomes; UP000005207; Linkage group LG11.
DR GO; GO:0009986; C:cell surface; IEA:UniProt.
DR GO; GO:0008305; C:integrin complex; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0007155; P:cell adhesion; IEA:UniProtKB-KW.
DR GO; GO:0007229; P:integrin-mediated signaling pathway; IEA:UniProtKB-KW.
DR CDD; cd01469; vWA_integrins_alpha_subunit; 1.
DR Gene3D; 2.130.10.130; Integrin alpha, N-terminal; 1.
DR Gene3D; 2.60.40.1460; Integrin domains. Chain A, domain 2; 1.
DR Gene3D; 2.60.40.1510; ntegrin, alpha v. Chain A, domain 3; 1.
DR Gene3D; 2.60.40.1530; ntegrin, alpha v. Chain A, domain 4; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR013517; FG-GAP.
DR InterPro; IPR013519; Int_alpha_beta-p.
DR InterPro; IPR000413; Integrin_alpha.
DR InterPro; IPR013649; Integrin_alpha_Ig-like_1.
DR InterPro; IPR048285; Integrin_alpha_Ig-like_2.
DR InterPro; IPR048286; Integrin_alpha_Ig-like_3.
DR InterPro; IPR028994; Integrin_alpha_N.
DR InterPro; IPR032695; Integrin_dom_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR23220; INTEGRIN ALPHA; 1.
DR PANTHER; PTHR23220:SF26; INTEGRIN ALPHA-10; 1.
DR Pfam; PF01839; FG-GAP; 2.
DR Pfam; PF08441; Integrin_A_Ig_1; 1.
DR Pfam; PF20805; Integrin_A_Ig_2; 1.
DR Pfam; PF20806; Integrin_A_Ig_3; 1.
DR Pfam; PF00092; VWA; 1.
DR PRINTS; PR01185; INTEGRINA.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00191; Int_alpha; 5.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF69318; Integrin alpha N-terminal domain; 1.
DR SUPFAM; SSF69179; Integrin domains; 3.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS51470; FG_GAP; 4.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Calcium {ECO:0000256|ARBA:ARBA00022837};
KW Cell adhesion {ECO:0000256|ARBA:ARBA00022889,
KW ECO:0000256|RuleBase:RU003762};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Integrin {ECO:0000256|ARBA:ARBA00023037, ECO:0000256|RuleBase:RU003762};
KW Membrane {ECO:0000256|ARBA:ARBA00023136};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Receptor {ECO:0000256|ARBA:ARBA00023170, ECO:0000256|RuleBase:RU003762};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|RuleBase:RU003762};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT SIGNAL 1..22
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT CHAIN 23..1192
FT /evidence="ECO:0000256|RuleBase:RU003762"
FT /id="PRO_5025718993"
FT REPEAT 24..85
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT DOMAIN 196..379
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REPEAT 501..563
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 565..623
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
FT REPEAT 627..687
FT /note="FG-GAP"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00803"
SQ SEQUENCE 1192 AA; 133464 MW; 4D1DB3B10DBA6F02 CRC64;
MELRKYLLCL EFILLLKELC QCFNIDVKHP RIFTGPEDAL FGFSVLQHEA DGEKSMLVGA
PWDGPPNNRK GDVYKCSVGR EKNSSCNKVN LGERNYELKK ICSIQFMFGF VTSMLRCLSR
SGETALQNVS KNLRNSHLGM TLTPTSPDGF LACAPLWSQE CGTSMFSTGI CASVSDDLEP
RETIAPTAQR CSTYMDIVIV LDGSNSIYPW YEVQNFLSNI LSKFHISSDQ MQVGILQYGE
VAIHEWSLKD YQTTQEVVEA AKNISRQEGR ETRTAYAIET ACTEAFSPER GAREGATKVM
IVVTDGESHD GDELEGALEK CKERNITRYA IAVLGHYIRR QQDPETFIKE IKFIASDPDD
KYFFNVTDEA ALNDIVDALG DRIFTLEGTL GYNESSFHME MSQIGFSTHT LDDGILFGMV
GAYDWDGGVL KEGTNGRIVP SREAFESEFP LELKNHAAYL GYTVTSVVTG DWKRVYVAGA
PRFKHKGKVI LFELSDEGDV NIVQALNGEQ IGSYFGSEVC GLDIDQDDIT DVLLVAAPMY
LGSGNKEAGR VYIYTLNRED VFVSNGTLKS NNKSQDARFG YALAPTPDLN HDGFTDLLVG
APLEDEHRGA IYVYHGDGIY VIHNYKQRIA ASSVSPSLQY FGRSLSARLD LDGDDLIDLA
VGAQGSAVLL SSRSIVQINV SLSFQPHSIN VIQKTCHRGG RESACLNATA CFTAVSRSPR
PHSNSFDLWV RAMLDDRKLS ARALFDDSSH RQTQLAVRAQ TGKTLCYKLP FHVYDTADYI
RPISFSLWFK INNTESGPVL DEGWPTTINK SIPFFKDCGE DDVCTTDLVL QAHMDISGTR
QKPYVIRSPR RRLAVEVQLQ NRLENAYNTS LTLNYSRNLH FSSISIREVA HFKIECTALS
ANSHSCNVSY PVFRSQSKVN FMLEFEFSCT SLHNQVKMKL HASSDSVERQ DTLKDNSVQL
QTFVQYEPDL FVSSESNLNR YEVHPTRTMS EAIGPEFYTH LRLQNLGCYS VSNLELRLHL
PSVAAGDRVF MTVTDVFSIN VTVNCSVLGD AAQLKARQGD VRPLHPEDMM QDDMLNCSRS
WCTEVVCQVK QLPRGKDAII RVSRRVHDDF FRHAKYKSVK IIGAYRLTAQ ETNLITLSAG
TVWREVRPKR ILSSTICIKL IFSNLSLHLF SLDRAGSAER PSYSHLALDS DR
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