ID I3JGY7_ORENI Unreviewed; 725 AA.
AC I3JGY7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Threonine synthase like 1 {ECO:0000313|Ensembl:ENSONIP00000008128.1};
GN Name=THNSL1 {ECO:0000313|Ensembl:ENSONIP00000008128.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000008128.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000008128.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- COFACTOR:
CC Name=pyridoxal 5'-phosphate; Xref=ChEBI:CHEBI:597326;
CC Evidence={ECO:0000256|ARBA:ARBA00001933,
CC ECO:0000256|PIRSR:PIRSR604450-51};
CC -!- PATHWAY: Amino-acid biosynthesis. {ECO:0000256|ARBA:ARBA00029440}.
CC -!- SIMILARITY: Belongs to the threonine synthase family.
CC {ECO:0000256|ARBA:ARBA00005517}.
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DR RefSeq; XP_003439211.1; XM_003439163.4.
DR AlphaFoldDB; I3JGY7; -.
DR STRING; 8128.ENSONIP00000008128; -.
DR Ensembl; ENSONIT00000008133.2; ENSONIP00000008128.1; ENSONIG00000006448.2.
DR GeneID; 100690353; -.
DR KEGG; onl:100690353; -.
DR CTD; 79896; -.
DR eggNOG; KOG2616; Eukaryota.
DR GeneTree; ENSGT00940000161144; -.
DR HOGENOM; CLU_015170_3_2_1; -.
DR InParanoid; I3JGY7; -.
DR OMA; FNRCQHL; -.
DR OrthoDB; 5309433at2759; -.
DR TreeFam; TF329641; -.
DR Proteomes; UP000005207; Linkage group LG9.
DR GO; GO:0030170; F:pyridoxal phosphate binding; IEA:InterPro.
DR GO; GO:0008652; P:amino acid biosynthetic process; IEA:UniProtKB-KW.
DR CDD; cd00464; SK; 1.
DR CDD; cd01560; Thr-synth_2; 1.
DR Gene3D; 3.40.50.1100; -; 2.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR Gene3D; 3.90.1380.10; Threonine synthase, N-terminal domain; 1.
DR HAMAP; MF_00109; Shikimate_kinase; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR000634; Ser/Thr_deHydtase_PyrdxlP-BS.
DR InterPro; IPR031322; Shikimate/glucono_kinase.
DR InterPro; IPR000623; Shikimate_kinase/TSH1.
DR InterPro; IPR029144; Thr_synth_N.
DR InterPro; IPR037158; Thr_synth_N_sf.
DR InterPro; IPR004450; Thr_synthase-like.
DR InterPro; IPR036052; TrpB-like_PALP_sf.
DR NCBIfam; TIGR00260; thrC; 1.
DR PANTHER; PTHR43515; THREONINE SYNTHASE-LIKE 1; 1.
DR PANTHER; PTHR43515:SF1; THREONINE SYNTHASE-LIKE 1; 1.
DR Pfam; PF01202; SKI; 1.
DR Pfam; PF14821; Thr_synth_N; 1.
DR PRINTS; PR01100; SHIKIMTKNASE.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR SUPFAM; SSF53686; Tryptophan synthase beta subunit-like PLP-dependent enzymes; 1.
DR PROSITE; PS00165; DEHYDRATASE_SER_THR; 1.
PE 3: Inferred from homology;
KW Amino-acid biosynthesis {ECO:0000256|ARBA:ARBA00022605};
KW Pyridoxal phosphate {ECO:0000256|ARBA:ARBA00022898,
KW ECO:0000256|PIRSR:PIRSR604450-51};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 214..297
FT /note="Threonine synthase N-terminal"
FT /evidence="ECO:0000259|Pfam:PF14821"
FT MOD_RES 330
FT /note="N6-(pyridoxal phosphate)lysine"
FT /evidence="ECO:0000256|PIRSR:PIRSR604450-51"
SQ SEQUENCE 725 AA; 80245 MW; C4C81B595684D106 CRC64;
MALLNTSQLP IRAARWCLSS LSTQKSWLST RSTCLGDKNI LLMGPPGAGK TTVGKIVAHK
LGLPVIDVDD DVLETAWKMP VAAKLAAVGG RCFLEEEGRA LCNFSASGCV VSLTGSNPLH
AEAMQHVKQS GLVIYLDVDS EDILQRLTSM KVNRIVGQEG GVSMKDILLY RKQFYEKWLD
VRVLCGTGDT VEEVAEKVLK AVERYQKSDE ETFISTRCDS TGLSKQKTYF SDVVVEGLAP
DGGLYVPKNG FPKIGTREWQ RLVEMSYPER ALVLLEKCIH PLDVSALDLR TMIFKAYGSN
FASKAVAPVK HLAHNQYIQE LFHGPTASFK DLALQLMPQL FAYCFPPMCN YLILVATSGD
TGSAVLSGFS RLSGTDRHRT GVLVFFPEGG VSAIQKLQMM SYREGNARAV SVLSDFDFCQ
RNIKRIFGEA GLTGHLAVEY GTVLSTGNSI NWARLLPQVV YHSSAYLDLC RDGIIKFGDP
IDVCIPTGNF GNAMSAVYAK QMGIPIRKVI CASNHNRVIT DFINTGQYDL RGRPLMLSHS
PAIDILRSSN LERFIYHVSD GNSHLVKDLF TRLDRQQHFQ VPEPLLGTIQ QEVLSGWCSE
DDCLAAIQRV HTQTGYVMDT HTAVAKVVAD RLQDGSCPVV FCSTAHYGKF APAVFKALQI
PNIPEDPIEQ LKKLELIASR PEMHREMIKC LKESAKRKHS ICEAEYSVLV DQVESMIQDS
FLKVM
//
