ID I3JMC1_ORENI Unreviewed; 259 AA.
AC I3JMC1;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 56.
DE RecName: Full=Integral membrane protein 2 {ECO:0000256|RuleBase:RU367061};
GN Name=ITM2C {ECO:0000313|Ensembl:ENSONIP00000010015.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010015.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010015.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Negative regulator of amyloid-beta peptide production. May
CC inhibit the processing of APP by blocking its access to alpha- and
CC beta-secretase. Binding to the beta-secretase-cleaved APP C-terminal
CC fragment is negligible, suggesting that ITM2C is a poor gamma-secretase
CC cleavage inhibitor. May play a role in TNF-induced cell death and
CC neuronal differentiation. {ECO:0000256|ARBA:ARBA00037782}.
CC -!- SUBUNIT: Interacts with BACE1. Interacts with APP. Interacts with
CC STMN2. {ECO:0000256|ARBA:ARBA00038611}.
CC -!- SUBCELLULAR LOCATION: Lysosome membrane
CC {ECO:0000256|ARBA:ARBA00037874}; Single-pass type II membrane protein
CC {ECO:0000256|ARBA:ARBA00037874}. Membrane
CC {ECO:0000256|RuleBase:RU367061}; Single-pass type II membrane protein
CC {ECO:0000256|RuleBase:RU367061}.
CC -!- SIMILARITY: Belongs to the ITM2 family. {ECO:0000256|ARBA:ARBA00006794,
CC ECO:0000256|RuleBase:RU367061}.
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DR RefSeq; XP_003459569.1; XM_003459521.4.
DR AlphaFoldDB; I3JMC1; -.
DR STRING; 8128.ENSONIP00000010015; -.
DR Ensembl; ENSONIT00000010023.2; ENSONIP00000010015.1; ENSONIG00000007951.2.
DR GeneID; 100692673; -.
DR KEGG; onl:100692673; -.
DR CTD; 436822; -.
DR eggNOG; KOG4681; Eukaryota.
DR GeneTree; ENSGT00950000183115; -.
DR HOGENOM; CLU_074596_0_0_1; -.
DR InParanoid; I3JMC1; -.
DR OMA; AGNCNHI; -.
DR OrthoDB; 3664639at2759; -.
DR TreeFam; TF317770; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005765; C:lysosomal membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-UniRule.
DR InterPro; IPR007084; BRICHOS_dom.
DR InterPro; IPR040145; ITM2.
DR PANTHER; PTHR10962:SF5; INTEGRAL MEMBRANE PROTEIN 2C; 1.
DR PANTHER; PTHR10962; INTEGRAL TRANSMEMBRANE PROTEIN 2; 1.
DR Pfam; PF04089; BRICHOS; 1.
DR SMART; SM01039; BRICHOS; 1.
DR PROSITE; PS50869; BRICHOS; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|RuleBase:RU367061};
KW Cleavage on pair of basic residues {ECO:0000256|ARBA:ARBA00022685};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367061};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal-anchor {ECO:0000256|RuleBase:RU367061};
KW Transmembrane {ECO:0000256|RuleBase:RU367061};
KW Transmembrane helix {ECO:0000256|RuleBase:RU367061}.
FT TRANSMEM 50..75
FT /note="Helical"
FT /evidence="ECO:0000256|RuleBase:RU367061"
FT DOMAIN 128..222
FT /note="BRICHOS"
FT /evidence="ECO:0000259|PROSITE:PS50869"
SQ SEQUENCE 259 AA; 30045 MW; A670A2C7366F842E CRC64;
MVKISFQAVS GQKVEKESDG DKTEILIPHP MDEEELVLPL RPKKSPLNGL CCLTFGLVVF
MAGLVLASIF VYRYYFIPHI PEENLFHCRV LYEDSVYAPL RGRQELEENV GIYLADNYEK
ITVPVPHFGG SDPADIIHDF HRGLTAYHDI ALDKCYVIEL NTTIVMPPRN LWELLINVKK
GTYLPQTYII HEEMVVTGKV HNMRQLGPFI YRLCNGKDTY RLNRRVTRRR INKRDTKDCH
HIRHFENTFV VETVICDEA
//
