ID I3JN14_ORENI Unreviewed; 1327 AA.
AC I3JN14;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 78.
DE RecName: Full=Clustered mitochondria protein homolog {ECO:0000256|HAMAP-Rule:MF_03013};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000010258.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000010258.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: mRNA-binding protein involved in proper cytoplasmic
CC distribution of mitochondria. Specifically binds mRNAs of nuclear-
CC encoded mitochondrial proteins in the cytoplasm and regulates transport
CC or translation of these transcripts close to mitochondria, playing a
CC role in mitochondrial biogenesis. {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|HAMAP-Rule:MF_03013}.
CC Cytoplasmic granule {ECO:0000256|HAMAP-Rule:MF_03013}.
CC -!- SIMILARITY: Belongs to the CLU family. {ECO:0000256|HAMAP-
CC Rule:MF_03013}.
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DR STRING; 8128.ENSONIP00000010258; -.
DR Ensembl; ENSONIT00000010267.2; ENSONIP00000010258.2; ENSONIG00000008146.2.
DR eggNOG; KOG1839; Eukaryota.
DR GeneTree; ENSGT00390000012485; -.
DR HOGENOM; CLU_003256_1_0_1; -.
DR InParanoid; I3JN14; -.
DR OMA; HPVWDKD; -.
DR TreeFam; TF300565; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0003723; F:RNA binding; IEA:UniProtKB-KW.
DR GO; GO:0007005; P:mitochondrion organization; IEA:UniProtKB-UniRule.
DR CDD; cd15466; CLU-central; 1.
DR Gene3D; 3.30.2280.10; Hypothetical protein (hspc210); 1.
DR Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 1.
DR HAMAP; MF_03013; CLU; 1.
DR InterPro; IPR033646; CLU-central.
DR InterPro; IPR025697; CLU_dom.
DR InterPro; IPR028275; CLU_N.
DR InterPro; IPR027523; CLU_prot.
DR InterPro; IPR023231; GSKIP_dom_sf.
DR InterPro; IPR011990; TPR-like_helical_dom_sf.
DR PANTHER; PTHR12601:SF10; CLUSTERED MITOCHONDRIA PROTEIN HOMOLOG; 1.
DR PANTHER; PTHR12601; EUKARYOTIC TRANSLATION INITIATION FACTOR 3 SUBUNIT EIF-3; 1.
DR Pfam; PF13236; CLU; 1.
DR Pfam; PF15044; CLU_N; 1.
DR Pfam; PF12807; eIF3_p135; 2.
DR Pfam; PF13424; TPR_12; 2.
DR SUPFAM; SSF103107; Hypothetical protein c14orf129, hspc210; 1.
DR SUPFAM; SSF48452; TPR-like; 2.
DR PROSITE; PS51823; CLU; 1.
PE 3: Inferred from homology;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490, ECO:0000256|HAMAP-Rule:MF_03013};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW RNA-binding {ECO:0000256|HAMAP-Rule:MF_03013}.
FT DOMAIN 342..584
FT /note="Clu"
FT /evidence="ECO:0000259|PROSITE:PS51823"
FT REGION 1..42
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 178..202
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 620..716
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1303..1327
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 16..35
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 626..704
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1327 AA; 148006 MW; 524D9EFC1D0EB8D8 CRC64;
EECARHSADT AMVNGDGAHE HTEETDSKQD GNGEADGGEE SNEQEVIVIQ DTGFTVKIQA
PGTEPFDLQV SPQEMVQEIH QVLMDREDTC HRTCFSLQLD GNVLDNFAEL KSIEGLQEGS
VLKVVEEPYT VREARIHVRH IRDLLKSLDP SDAYNGVDCN SLSFLSIFTD GDLGETGKRK
KKGNEMEQID CTPPEHILPG SKERPLVPLQ PQNKDWKPMQ CLKVLTMSGW NPPPGNRKMH
GDLMYLYIVT VEERHVSVTA STRGFYLNQS TTYTFNPKPA NPSFLSHSLV ELLSQISPAF
KKNFTALQKK RVQRHPFERI ATPFQVYSWT APQVDHAMDC VRAEDAYTSR LGYEEHIPGQ
TRDWNEELQT TRELPRKNLP ERLLRERAIF KVHSDFAAAA TRGAMAVIDG NVMAINPGEE
TRMQMFIWNN IFFSLGFDVR DHYRELGGDA AAHAAPTNDL NGVRAYSGVD VEGLYTLGTV
VVDYRGYRVT AQSIIPGILE REQEQSVIYG SIDFGKTVVS HGKYLELLEK TSRPLKVQRH
SVLNEKNDTV ELCSSVECKG IIGNDGRHYI LDLLRTFPPD LNFLPVDGVE LSPECQRLGF
PAMTLLLFLM AALQLMQHKA NRDSNKTDTP AITETSETLT ESKASTTQTD TAQTTATDSS
KATDISTDST SQTDNASTAA SQTGTDSEEN SSKPTTNGPV DPTATQNGEC KGPLEGKELE
ESIPGLAQAK ELAETLVAED GSSIDPKSRE VVLNACKAVG SISDTAFDIR FNPDIFSPGV
RFPEESADDI QKQKQLLKDA AAFLVSCQVP TLVKDCLDHS ALPMDGASLT EALHQRGINV
RYLGTVLEFM EKTPAKAQLE LVTFNGTTFS LSALSAAVSH FLNCFLSSFP DAVAHLPPDE
LVSRRKNRKR RNRVPGGGDN TAWASLTPSE LWKNIASEAQ SYYHFTLQCE SVDQVVEKFG
LQKITLLREI SVKTGIQILI KEYNFDSRHK PAFTEEDILN IFPVVKHVNP KATDAFHFFQ
SGQAKVQQGF LKEGCELINE ALNLFNNVYG AMHVEICSCL RLLARLNYIL GDHPEALSNQ
QKAVLMSERV LGIEHPNTIQ EYMHLALYCF ANNQLSTALK LLYRARYLML LICGEDHPEM
ALLDSNIGLV LHGVMEYDLS LRFLENALTI NTKYHGPRSL KVALSHHLVA RVYESKAEFR
SALQHEKEGY TIYKNQMGEA HEKTKESSEY LKYLTQQAVA LQRTMNEIYK NGSNASIMPL
KFTAPSMATI LDQLNIINGI IFIPLSPKDL ENLKAEVQRR QQLQELGKGE EPAEDRSLEL
EDKIPID
//
