ID   I3JQU2_ORENI            Unreviewed;       593 AA.
AC   I3JQU2;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Protein tyrosine phosphatase non-receptor type 9b {ECO:0000313|Ensembl:ENSONIP00000011236.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011236.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000011236.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JQU2; -.
DR   Ensembl; ENSONIT00000011245.2; ENSONIP00000011236.2; ENSONIG00000008940.2.
DR   GeneTree; ENSGT00940000165569; -.
DR   HOGENOM; CLU_016977_1_0_1; -.
DR   Proteomes; UP000005207; Linkage group LG6.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:InterPro.
DR   GO; GO:0016311; P:dephosphorylation; IEA:InterPro.
DR   CDD; cd00170; SEC14; 1.
DR   Gene3D; 3.40.525.10; CRAL-TRIO lipid binding domain; 1.
DR   Gene3D; 1.10.8.20; N-terminal domain of phosphatidylinositol transfer protein sec14p; 1.
DR   Gene3D; 3.90.190.10; Protein tyrosine phosphatase superfamily; 1.
DR   InterPro; IPR001251; CRAL-TRIO_dom.
DR   InterPro; IPR036865; CRAL-TRIO_dom_sf.
DR   InterPro; IPR011074; CRAL/TRIO_N_dom.
DR   InterPro; IPR036273; CRAL/TRIO_N_dom_sf.
DR   InterPro; IPR029021; Prot-tyrosine_phosphatase-like.
DR   InterPro; IPR000242; PTP_cat.
DR   InterPro; IPR003595; Tyr_Pase_cat.
DR   InterPro; IPR000387; Tyr_Pase_dom.
DR   PANTHER; PTHR19134; RECEPTOR-TYPE TYROSINE-PROTEIN PHOSPHATASE; 1.
DR   PANTHER; PTHR19134:SF328; TYROSINE-PROTEIN PHOSPHATASE NON-RECEPTOR TYPE 9; 1.
DR   Pfam; PF00650; CRAL_TRIO; 1.
DR   Pfam; PF00102; Y_phosphatase; 1.
DR   PRINTS; PR00700; PRTYPHPHTASE.
DR   SMART; SM01100; CRAL_TRIO_N; 1.
DR   SMART; SM00194; PTPc; 1.
DR   SMART; SM00404; PTPc_motif; 1.
DR   SMART; SM00516; SEC14; 1.
DR   SUPFAM; SSF52799; (Phosphotyrosine protein) phosphatases II; 1.
DR   SUPFAM; SSF52087; CRAL/TRIO domain; 1.
DR   SUPFAM; SSF46938; CRAL/TRIO N-terminal domain; 1.
DR   PROSITE; PS50191; CRAL_TRIO; 1.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50055; TYR_PHOSPHATASE_PTP; 1.
PE   4: Predicted;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          75..234
FT                   /note="CRAL-TRIO"
FT                   /evidence="ECO:0000259|PROSITE:PS50191"
FT   DOMAIN          307..528
FT                   /note="Tyrosine-protein phosphatase"
FT                   /evidence="ECO:0000259|PROSITE:PS50055"
FT   DOMAIN          487..528
FT                   /note="Tyrosine specific protein phosphatases"
FT                   /evidence="ECO:0000259|PROSITE:PS50056"
SQ   SEQUENCE   593 AA;  68062 MW;  926153A94F7BC7CD CRC64;
     MDAEYSDQNK LTAVEEFLSE VRSREQPHSA GLVSQPTAVK FLMARKFDVS RAIDLFQAYK
     NTRIKEGIIN INPDEEPLRS ELLSGKFTVL PGRDAKGAAV ALFTARLHRP DLTTHKAVLQ
     AIIYQLDKAI ESVQTQRDGL IFIYDMTNSS YGNFDYELCV KILNLLKGAF PARLKCVFIV
     SSPLWFRAPF AVLRLFVREK LRERVCTVKA HELASHIPVS SLPEHLGGTS QYNHVAWIQS
     CVNVNTNIVQ GDTKEHDCVG SLLRSYSLEN SNTSNHCMEV SVHMPEQGAM TVHDLVEYVK
     RKKKRGIYQE YEEIRKEPPA GTFDYSKKLS NQVKNRYSDV LCLDQSRVRL CPLSNDEDET
     SDYINASFMD GYKRSNAYIA TQGPLPKTFA DFWRMVWEQM VLIIVMTTRV VERGRVKCGQ
     YWPLEEGRTE QHGYFLVRNT HIQVFQDFKL SHLELYNTQS GERREVCHYL YVSWPDFGVP
     KSASAMLDFR EHVLQRREAA VQTLGSTWRG PPGGPPVVVH CSAGIGRTVY HRNGNVNIQL
     SGPLMPRTKQ KQTKKLLREE NGKKKKTWLH FCSYKYISIY YYGIKFISME REP
//