ID I3JR59_ORENI Unreviewed; 1500 AA.
AC I3JR59;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 79.
DE SubName: Full=Slit homolog 2 (Drosophila) {ECO:0000313|Ensembl:ENSONIP00000011353.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011353.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011353.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00076}.
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DR Ensembl; ENSONIT00000011362.2; ENSONIP00000011353.2; ENSONIG00000009028.2.
DR eggNOG; KOG4237; Eukaryota.
DR GeneTree; ENSGT00940000158402; -.
DR TreeFam; TF332887; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00054; EGF_CA; 6.
DR CDD; cd00110; LamG; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 8.
DR Gene3D; 3.80.10.10; Ribonuclease Inhibitor; 5.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR000483; Cys-rich_flank_reg_C.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR013032; EGF-like_CS.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR000152; EGF-type_Asp/Asn_hydroxyl_site.
DR InterPro; IPR018097; EGF_Ca-bd_CS.
DR InterPro; IPR001791; Laminin_G.
DR InterPro; IPR001611; Leu-rich_rpt.
DR InterPro; IPR003591; Leu-rich_rpt_typical-subtyp.
DR InterPro; IPR032675; LRR_dom_sf.
DR InterPro; IPR000372; LRRNT.
DR PANTHER; PTHR45836:SF23; LRRCT DOMAIN-CONTAINING PROTEIN; 1.
DR PANTHER; PTHR45836; SLIT HOMOLOG; 1.
DR Pfam; PF00008; EGF; 5.
DR Pfam; PF12661; hEGF; 1.
DR Pfam; PF02210; Laminin_G_2; 1.
DR Pfam; PF13855; LRR_8; 6.
DR Pfam; PF01463; LRRCT; 4.
DR Pfam; PF01462; LRRNT; 4.
DR PRINTS; PR00010; EGFBLOOD.
DR SMART; SM00181; EGF; 9.
DR SMART; SM00179; EGF_CA; 6.
DR SMART; SM00282; LamG; 1.
DR SMART; SM00368; LRR_RI; 4.
DR SMART; SM00365; LRR_SD22; 7.
DR SMART; SM00369; LRR_TYP; 20.
DR SMART; SM00082; LRRCT; 4.
DR SMART; SM00013; LRRNT; 4.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF57196; EGF/Laminin; 6.
DR SUPFAM; SSF52058; L domain-like; 3.
DR PROSITE; PS00010; ASX_HYDROXYL; 2.
DR PROSITE; PS00022; EGF_1; 9.
DR PROSITE; PS01186; EGF_2; 8.
DR PROSITE; PS50026; EGF_3; 9.
DR PROSITE; PS01187; EGF_CA; 2.
DR PROSITE; PS50025; LAM_G_DOMAIN; 1.
DR PROSITE; PS51450; LRR; 4.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00076};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536, ECO:0000256|PROSITE-
KW ProRule:PRU00076}; Leucine-rich repeat {ECO:0000256|ARBA:ARBA00022614};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 903..938
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 940..979
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 981..1017
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1019..1057
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1059..1095
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1104..1140
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1143..1309
FT /note="Laminin G"
FT /evidence="ECO:0000259|PROSITE:PS50025"
FT DOMAIN 1313..1344
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1347..1383
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DOMAIN 1389..1425
FT /note="EGF-like"
FT /evidence="ECO:0000259|PROSITE:PS50026"
FT DISULFID 928..937
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 969..978
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1007..1016
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1047..1056
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1085..1094
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1130..1139
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1282..1309
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00122"
FT DISULFID 1334..1343
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1351..1361
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1373..1382
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1393..1403
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
FT DISULFID 1415..1424
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00076"
SQ SEQUENCE 1500 AA; 166143 MW; 7C6FECEC16786513 CRC64;
YLLTGADGQP CPAQCSCTGT TVDCHGQGLR SVPRNIPRNT ERLDLNANNL TKITKTDFAG
LRHLRVLQLM ENKITTIERG AFQDLKELER LRLNRNNLAV FPELLFLGTT KLYRLDLSEN
QIQGIPRKAF RGAVEIKNLQ LDYNHISCIE DGAFRALRDL EVLTLNNNNI SRLSVASFNH
MPKLRTFRLH SNNLQCDCHV AWLSEWLRQR PRLGLYTQCM APPHLRGHNV AEVQKKEFVC
TGHQSSSSSS CSVLQCPESC TCSNNIVDCR GKGLTEIPTN LPETITEIRL EQNAIKVIPA
GAFSPYKKLR RIDLSNNQIS ELASDAFQGL RSLNSLVLYG NKITEISKGL FEGLFSLQLL
LLNANKIACL RVDAFQDLHN LNLLSLYDNK LQTIAKGTFS SLRAIQTLHL AQNPFICDCH
LKWLADYLQD NPIETSGARC TSPRRLANKR IGQIKSKKFR CSAREQYFIP GNEDYRSKLG
GDCFADLACP EKCRCEGTTV DCSNQKLTKI PDHIPQYTTE LRLNNNEFSV LEATGIFKKL
PQLRKINLSN NRITDIEEGT FEGASGVNEL ILTSNRLENI HHRILKGLSG LRTLMLRSNR
ISCVSNSSFV GLSSVRLLSL YDNQITSMNP GAFDTLHSLS TLNLLANPFN CNCHLAWLGD
WLRRKRIVTG NPRCQSPYFL KEIPIQDVAV QDFACEDGND ENSCSPMLRC PAECSCLDTV
VRCSNKGLTT LPRGLPKETT ELYLDGNHFT QVPVELSNYK HLTLIDLSNN QISTLSNHSL
SNMSELLTLI LSYNRLRCIP ERAFDGLKSL RLLSLHGNDI SLIPEGAFKD LSSLSHLALG
ANPLYCDCHM QWLSDWVKSG YKEPGIARCA GPGDMTDKLL LTTPSKKFTC TGPVDINIQA
KCHPCLSNPC KNDGTCANDP VHYYRCTCPY GFKGQNCDEP IHACISNPCQ NGGTCHLKEG
EGSNFWCVCP EGFEGDACEI NIDDCEDNDC ENNSTCVDGI NNYTCMCSPE YTGELCEEKL
DFCAPELNPC QHDSKCILIP QGYKCECIPG FIGEHCELDY DDCEENKCQN GGQCIDAVNG
YTCICPEGYS GLFCEFSPPM VLPRTSPCDN HECLNGAQCV IVGSDPRCQC LHGYEGERCE
TLASVNFVNR ESYLQLPSSL LSPQTNISLQ IATDEDSGVL LYKGDNDHIA MELYRGRLRV
SYDTGSYPPS AIYSVETVND GNFHAVELVA SDQTLSLSID GGPPKSINSL NKQSTLNIDS
PLYVGGKDST SGGRNGTSFH GCLRNLYING KLQDLGAGKW LGNGVEPGCQ PCQRGACVQG
DCHPTGHRGF TCTCHAGWTG TLCDQQVSNP CDGNKCIHGT CIPINSYSYS CRCQPGFAGV
LCDEQDQDAA NPCSLSRCKH GKCRVSGLGK AYCECNSGYT GEACDREVAC RGERVRDVYQ
RQQGYAACQT QEKVSRLETG HLLHPLRSKR RKYTFQCTDG SSFVQEVEKV VKCGCTKCSL
//
