ID I3JRE3_ORENI Unreviewed; 951 AA.
AC I3JRE3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 64.
DE SubName: Full=SLIT-ROBO Rho GTPase-activating protein 3 {ECO:0000313|Ensembl:ENSONIP00000011437.2};
GN Name=ARHGAP4 {ECO:0000313|Ensembl:ENSONIP00000011437.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011437.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011437.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005454116.1; XM_005454059.3.
DR AlphaFoldDB; I3JRE3; -.
DR Ensembl; ENSONIT00000011446.2; ENSONIP00000011437.2; ENSONIG00000009094.2.
DR GeneID; 100709810; -.
DR eggNOG; KOG3565; Eukaryota.
DR GeneTree; ENSGT00950000182824; -.
DR HOGENOM; CLU_005715_1_2_1; -.
DR InParanoid; I3JRE3; -.
DR OMA; ECAGARG; -.
DR OrthoDB; 2904755at2759; -.
DR TreeFam; TF315892; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0007165; P:signal transduction; IEA:InterPro.
DR CDD; cd07656; F-BAR_srGAP; 1.
DR CDD; cd11956; SH3_srGAP4; 1.
DR Gene3D; 1.20.1270.60; Arfaptin homology (AH) domain/BAR domain; 1.
DR Gene3D; 1.10.555.10; Rho GTPase activation protein; 1.
DR Gene3D; 2.30.30.40; SH3 Domains; 1.
DR InterPro; IPR027267; AH/BAR_dom_sf.
DR InterPro; IPR031160; F_BAR.
DR InterPro; IPR001060; FCH_dom.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR000198; RhoGAP_dom.
DR InterPro; IPR036028; SH3-like_dom_sf.
DR InterPro; IPR001452; SH3_domain.
DR InterPro; IPR035678; srGAP4_SH3.
DR PANTHER; PTHR14166:SF16; RHO GTPASE-ACTIVATING PROTEIN 4; 1.
DR PANTHER; PTHR14166; SLIT-ROBO RHO GTPASE ACTIVATING PROTEIN; 1.
DR Pfam; PF00611; FCH; 1.
DR Pfam; PF00620; RhoGAP; 1.
DR Pfam; PF00018; SH3_1; 1.
DR PRINTS; PR01887; SPECTRNALPHA.
DR SMART; SM00055; FCH; 1.
DR SMART; SM00324; RhoGAP; 1.
DR SMART; SM00326; SH3; 1.
DR SUPFAM; SSF103657; BAR/IMD domain-like; 1.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF50044; SH3-domain; 1.
DR PROSITE; PS51741; F_BAR; 1.
DR PROSITE; PS50238; RHOGAP; 1.
DR PROSITE; PS50002; SH3; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054, ECO:0000256|PROSITE-
KW ProRule:PRU01077}; Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH3 domain {ECO:0000256|ARBA:ARBA00022443, ECO:0000256|PROSITE-
KW ProRule:PRU00192}.
FT DOMAIN 23..304
FT /note="F-BAR"
FT /evidence="ECO:0000259|PROSITE:PS51741"
FT DOMAIN 490..676
FT /note="Rho-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50238"
FT DOMAIN 715..774
FT /note="SH3"
FT /evidence="ECO:0000259|PROSITE:PS50002"
FT REGION 184..203
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 388..407
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 774..869
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 894..935
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 8..46
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 794..841
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 910..931
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 951 AA; 106622 MW; 591CCC5A397B8458 CRC64;
MMTSHGKLRR EKGSLAEYES QMKDLRAQLT DQIKILDSQV EVKQQQLSDL SEFLRRRGDI
ESEYARALDK LTERFTHKTK KKEQWGQSVC QVWSVLLTQT RLESREHAAL GDTCCNTLTQ
RLAHGTEDTH RLHKRSKEVG IQMQDELLKV TTELQTALKT YNQYHTDCLI AEGKLKEAER
LEERHTGKSA ELGPGQLGGQ RRSSVKKMER LMEKRHGRVQ ETQLKCTKAR NDYLLNLAGA
NAAMNKYYLQ DVSTLIDCCD LGFHLSVETV MKCYLASRWR IQKTEETGLK QLETAVTSLD
QSGDRDALLQ QHDAAFCLPF RFNYHPHEGD QVCEVSAESQ VRYELETRFQ QLQSRLAAVT
LETEEISKTL KATLAALLDT MCDSDCNPSP DVPSNLSHEP PGGGTLPKLT LAKRRANQQE
TETYYFTKVK EFLTSSSLAS KLQAKHDILQ DAIQKAEAVD SDPSRMQCAR SVRVRKSRPV
SQFCHTLFNT DILSYIESSG QQIPVVVESC IRFINLHGLH HEGIFRVPGS QREVNLLRDA
FERGEDPLSD SECDLDSVAG VLKLYFRGLE PPLFPYDSYT QLLECVQIEE EVEKAVQIKT
IVSTFPRPLL IVMRYLFAFL NHVSQYSDEN MMQPYNLAVC FGPSLLRGMD SDDAVARQPQ
VNDLVKTMIL QHDSIFPSQS ELPGPVYEKH MTLEQEYCEP ITEEGDGETE HLPSEDEWEA
VAMFDYVARS PAELSFKQGE PLILHSKASS DWWRGEVGGV KGLIPHKYIS VLEGSDRGKR
EEGGGGGGGG STGNLTAEDP QTENTTRMRV NSDSASLPGR QRGSEGSPSR KPPTSPATRH
LPVSQERRHT LDTLRQGNFR PPDRPPFIQA ERTPIDKEMI NRQMNSVFKE LLSRQPPLQG
PGITAPVATA APAPSSSSSS LSTSSSVPQS APVAKKAGFG LRGRALFRPV D
//
