ID I3JSY9_ORENI Unreviewed; 578 AA.
AC I3JSY9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 59.
DE SubName: Full=Anthrax toxin receptor 1 {ECO:0000313|Ensembl:ENSONIP00000011984.1};
GN Name=LOC100710917 {ECO:0000313|Ensembl:ENSONIP00000011984.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000011984.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000011984.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the ATR family. {ECO:0000256|ARBA:ARBA00008095}.
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DR RefSeq; XP_003441141.1; XM_003441093.4.
DR AlphaFoldDB; I3JSY9; -.
DR STRING; 8128.ENSONIP00000057717; -.
DR Ensembl; ENSONIT00000011993.2; ENSONIP00000011984.1; ENSONIG00000009537.2.
DR GeneID; 100710917; -.
DR KEGG; onl:100710917; -.
DR CTD; 563132; -.
DR eggNOG; ENOG502QSKR; Eukaryota.
DR GeneTree; ENSGT00940000157727; -.
DR HOGENOM; CLU_029760_0_0_1; -.
DR OrthoDB; 5397560at2759; -.
DR TreeFam; TF328943; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0038023; F:signaling receptor activity; IEA:InterPro.
DR CDD; cd01474; vWA_ATR; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 1.
DR InterPro; IPR008399; Anthrax_toxin_rcpt_C.
DR InterPro; IPR008400; Anthrax_toxin_rcpt_extracel.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR16059; ANTHRAX TOXIN RECEPTOR; 1.
DR PANTHER; PTHR16059:SF16; ANTHRAX TOXIN RECEPTOR-LIKE; 1.
DR Pfam; PF05586; Ant_C; 1.
DR Pfam; PF05587; Anth_Ig; 1.
DR Pfam; PF00092; VWA; 1.
DR SMART; SM00327; VWA; 1.
DR SUPFAM; SSF53300; vWA-like; 1.
DR PROSITE; PS50234; VWFA; 1.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..578
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5003672997"
FT TRANSMEM 320..341
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 45..213
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 354..376
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 396..445
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 466..578
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 396..434
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 529..578
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 578 AA; 64289 MW; CD3C187D8F77C5B3 CRC64;
MARTRARMFL VLAVVGIFCL DVSVRGELQG EQQEEEERSC QGAFDLYFVL DKSGSVKHHW
IEIYSFVEQL AEKFISPMLR MSFIVFSTQG KIIMKLTENR EDITGGLMAL RKVIPGGDTY
MNLGLEMANA QIYKEKQGTA SVIIALTDGE LNEWQFDTAQ REAQRARSMG AIVYCVGVKE
FNQTQLATIA DTVEHVFPVW GGFQALRGII DSIIKKSCIE ILAAEPSSVC AGESFQVVVR
GNGFLHARNI NQVLCSFKLN DTHTVDERPA GIEDTFLLCP APVVKEVGKV IYLQVSMNEG
LSYITSSVHI TTTECFDGTI VLISLLVVFL LLALLLMWWF WPLCCTVVIK EPPPPPPPEP
ESDDDDGLPK KKWPTVDASY YGGRGVGGIK RMEVRWGEKG STEEGAKLDK PKNAVVKMPE
QEFEPYEPKP RKPPRRPPQQ RRWYTPIQGK LDAIWALFRR GYDQVSLMRP QPGDEGRCIR
FQRVKDGEST PNNQAPPRAH CSPSAPPAPP LFEQQPLVSY SVPRTKPPSR GPRTTPPSST
TPPARAPPSM VRPPPCPPPT RTPPGPPGPP PSRPPPRL
//
