ID I3JUV8_ORENI Unreviewed; 816 AA.
AC I3JUV8;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Vitrin {ECO:0000313|Ensembl:ENSONIP00000012653.2};
GN Name=VIT {ECO:0000313|Ensembl:ENSONIP00000012653.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000012653.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000012653.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005473999.1; XM_005473942.3.
DR AlphaFoldDB; I3JUV8; -.
DR Ensembl; ENSONIT00000012663.2; ENSONIP00000012653.2; ENSONIG00000010061.2.
DR GeneID; 100691337; -.
DR KEGG; onl:100691337; -.
DR CTD; 5212; -.
DR GeneTree; ENSGT00940000159330; -.
DR InParanoid; I3JUV8; -.
DR OMA; VMEPNFA; -.
DR OrthoDB; 2883115at2759; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR CDD; cd01472; vWA_collagen; 1.
DR Gene3D; 2.170.130.20; LCCL-like domain; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR004043; LCCL.
DR InterPro; IPR036609; LCCL_sf.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR PANTHER; PTHR24020:SF23; VITRIN; 1.
DR Pfam; PF03815; LCCL; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00603; LCCL; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF69848; LCCL domain; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS50820; LCCL; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..21
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 22..816
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025582568"
FT DOMAIN 34..127
FT /note="LCCL"
FT /evidence="ECO:0000259|PROSITE:PS50820"
FT DOMAIN 431..616
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 633..802
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT REGION 157..208
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 225..310
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 157..192
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 226..249
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 289..303
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 816 AA; 90102 MW; 55E2766C05CA1635 CRC64;
MIRASLTAIC LALLLSYQCW AKPNGPKNKK PKQVIPAIEC DVRAGKVSLP EFIVKCPPRC
RETKQQVYGT GVFASISSIC NAAIHSGVIT NSGGKVIVRK MAGQNVYKGS NSNGVRSLSL
PKWRESFVVS VGKPKKGVIY PSTLDYVPSR PTYVKTNQKE TITVPPTTTA PEPTTTTPEP
TTTTITTPTP TTASTTTPPP PTTKARPVVH KVREAGSIHP YLAHAAASNS RQSQSGQRKS
PSQVFRGGSY SHRFPQRASA GIHKQEPGQA VRRQPSSPVG PGFNRVQPAQ PERTPTMSQS
NPALPRRDWP LPSFPHPDWF PGARRPADVS YAAPDSGYAW SETGTPEVTA RDYRPDISEY
ERWYYNLGQY LHRSADPDRK IMDTANTKVE PVDAWNPEAP PYELGFSVRE QEPLRRAPEP
VSQGNPDCKV DLAFLMDGSW SIGKRRFKIQ KDFLTEVAQT INVGVAGPMM GIIQYGDDPV
TEISLKTHSS SRELKAAIDK IVQKGGLSNV GKALHYINKH YFSDANGNRG GAPNVAVILV
DGWPTDKVEE ASRLARESGI NIFFVTIEGP DDNEKQNLIE ANFVDKAVCR TNGFFSLPVN
SWFALRKAVQ PLVKRVCDTD RLVCSKTCLN ANDIAFVIDG SSSVGTGNFR TVLQFVANIT
REFEISDTDT RVGAVQYTYE QRLEFAFGQY NNKAELLNAI KRINYWSGGT STGAAITYAA
EQLFSKSKPN KRKIMIVITD GRSYDDVRAP ALAVHRQGVI AYSIGIAWAA QDELEYIATD
PDKEHSFFVD EFDNLYKFVP KIIHNICQEF NSQPRN
//
