ID   I3JVY0_ORENI            Unreviewed;       310 AA.
AC   I3JVY0;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 67.
DE   SubName: Full=Protein arginine N-methyltransferase 8-B {ECO:0000313|Ensembl:ENSONIP00000013025.2};
GN   Name=PRMT8 {ECO:0000313|Ensembl:ENSONIP00000013025.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013025.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000013025.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
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DR   AlphaFoldDB; I3JVY0; -.
DR   STRING; 8128.ENSONIP00000013026; -.
DR   Ensembl; ENSONIT00000013035.2; ENSONIP00000013025.2; ENSONIG00000010362.2.
DR   eggNOG; KOG1499; Eukaryota.
DR   GeneTree; ENSGT00940000155867; -.
DR   HOGENOM; CLU_017375_1_1_1; -.
DR   TreeFam; TF300608; -.
DR   Proteomes; UP000005207; Linkage group LG7.
DR   GO; GO:0016274; F:protein-arginine N-methyltransferase activity; IEA:InterPro.
DR   GO; GO:0032259; P:methylation; IEA:UniProtKB-KW.
DR   CDD; cd02440; AdoMet_MTases; 1.
DR   Gene3D; 2.70.160.11; Hnrnp arginine n-methyltransferase1; 1.
DR   Gene3D; 3.40.50.150; Vaccinia Virus protein VP39; 1.
DR   InterPro; IPR025799; Arg_MeTrfase.
DR   InterPro; IPR041698; Methyltransf_25.
DR   InterPro; IPR029063; SAM-dependent_MTases_sf.
DR   PANTHER; PTHR11006; PROTEIN ARGININE N-METHYLTRANSFERASE; 1.
DR   PANTHER; PTHR11006:SF47; PROTEIN ARGININE N-METHYLTRANSFERASE 8; 1.
DR   Pfam; PF13649; Methyltransf_25; 1.
DR   SUPFAM; SSF53335; S-adenosyl-L-methionine-dependent methyltransferases; 1.
DR   PROSITE; PS51678; SAM_MT_PRMT; 1.
PE   4: Predicted;
KW   Methyltransferase {ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   S-adenosyl-L-methionine {ECO:0000256|ARBA:ARBA00022691,
KW   ECO:0000256|PROSITE-ProRule:PRU01015};
KW   Transferase {ECO:0000256|PROSITE-ProRule:PRU01015}.
FT   DOMAIN          31..128
FT                   /note="Methyltransferase"
FT                   /evidence="ECO:0000259|Pfam:PF13649"
SQ   SEQUENCE   310 AA;  35887 MW;  6A651075452A46E0 CRC64;
     MAGEMLKDEV RTLTYRNSMY HNKHIFKDKI VLDVGSGTGI LSMFAAKAGA KHVYGIECSS
     ISEYSERIIK SNHLDSVITI FKGKVEEVEL PVEKVDIIIS EWMGYCLFYE SMLNTVIFAR
     DKWLKPGGLM FPDRASLYVV AIEDRQYKDF KIHWWENVYG FDMTCIRNVA MKEPLVDVVD
     PKQVVTNSCL VKEVDIYTVK PEDLSFTSAF CLQIQRNDYI HALVTYFNIE FTKCHKKTGF
     STAPDAPYTH WKQTVFYLED YLTVRRGEEI VGSIAMKPNE KNVRDLDFTF ELDFKGQLCE
     AAISHDYKMR
//