ID I3JWJ3_ORENI Unreviewed; 299 AA.
AC I3JWJ3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 62.
DE SubName: Full=Artemin {ECO:0000313|Ensembl:ENSONIP00000013238.2};
GN Name=LOC102075588 {ECO:0000313|Ensembl:ENSONIP00000013238.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013238.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013238.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC -!- SIMILARITY: Belongs to the TGF-beta family. GDNF subfamily.
CC {ECO:0000256|ARBA:ARBA00009832}.
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DR RefSeq; XP_005476111.1; XM_005476054.3.
DR RefSeq; XP_019202900.1; XM_019347355.1.
DR AlphaFoldDB; I3JWJ3; -.
DR STRING; 8128.ENSONIP00000013238; -.
DR Ensembl; ENSONIT00000013248.2; ENSONIP00000013238.2; ENSONIG00000010531.2.
DR GeneID; 102075588; -.
DR KEGG; onl:102075588; -.
DR eggNOG; ENOG502S53F; Eukaryota.
DR GeneTree; ENSGT00950000182993; -.
DR HOGENOM; CLU_1309766_0_0_1; -.
DR InParanoid; I3JWJ3; -.
DR OMA; STWHALY; -.
DR OrthoDB; 4316464at2759; -.
DR TreeFam; TF332366; -.
DR Proteomes; UP000005207; Linkage group LG18.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0030116; F:glial cell-derived neurotrophic factor receptor binding; IEA:InterPro.
DR GO; GO:0008083; F:growth factor activity; IEA:UniProtKB-KW.
DR GO; GO:0030971; F:receptor tyrosine kinase binding; IEA:InterPro.
DR GO; GO:0048731; P:system development; IEA:UniProt.
DR Gene3D; 2.10.90.10; Cystine-knot cytokines; 1.
DR InterPro; IPR029034; Cystine-knot_cytokine.
DR InterPro; IPR043401; GDNF_fam.
DR InterPro; IPR001839; TGF-b_C.
DR PANTHER; PTHR12173:SF9; ARTEMIN; 1.
DR PANTHER; PTHR12173; GDNF SUBFAMILY OF TGF-BETA FAMILY; 1.
DR Pfam; PF00019; TGF_beta; 1.
DR SUPFAM; SSF57501; Cystine-knot cytokines; 1.
DR PROSITE; PS51362; TGF_BETA_2; 1.
PE 3: Inferred from homology;
KW Growth factor {ECO:0000256|ARBA:ARBA00023030,
KW ECO:0000256|RuleBase:RU000354};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 186..298
FT /note="TGF-beta family profile"
FT /evidence="ECO:0000259|PROSITE:PS51362"
FT REGION 143..204
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 173..189
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 299 AA; 33725 MW; E158747CC4FCBE85 CRC64;
MTHRSVWIAK NMSCCTQRGR RRRRRSGFPV LCGAEQDARR TAGGTRWRIR RADRQDVTSA
KGKVLLWVLI ALLPLVEGAH MKGGVGVGSE SGHAVGLLGN QEERQLPVTL PEMVEDKEQK
EDSDPYSTWH PLYDPFVMDE VDDHPSSRWV GRSPRSSDPT EPQPKGSSKK KKKKKEKEEE
TETGNRKGRG RNGPPKQSSR HCRVEKKEMR VRDLGLGFDS DEIVLFKFCV GSCQAERTNY
DLALKALLEN GSLPRRTARK VSSHPCCRPD RYEPVSFMDA KTTWRTIQSL SAASCMCMG
//
