ID I3JWR4_ORENI Unreviewed; 922 AA.
AC I3JWR4;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 65.
DE SubName: Full=Kinase suppressor of ras 2 {ECO:0000313|Ensembl:ENSONIP00000013309.2};
GN Name=KSR2 {ECO:0000313|Ensembl:ENSONIP00000013309.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013309.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013309.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR AlphaFoldDB; I3JWR4; -.
DR STRING; 8128.ENSONIP00000013310; -.
DR Ensembl; ENSONIT00000013319.2; ENSONIP00000013309.2; ENSONIG00000010586.2.
DR eggNOG; KOG0193; Eukaryota.
DR GeneTree; ENSGT00940000158519; -.
DR TreeFam; TF317006; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0004672; F:protein kinase activity; IEA:InterPro.
DR GO; GO:0048468; P:cell development; IEA:UniProt.
DR Gene3D; 3.30.60.20; -; 1.
DR Gene3D; 6.10.140.1120; -; 1.
DR Gene3D; 1.10.150.50; Transcription Factor, Ets-1; 1.
DR Gene3D; 1.10.510.10; Transferase(Phosphotransferase) domain 1; 1.
DR InterPro; IPR046349; C1-like_sf.
DR InterPro; IPR011009; Kinase-like_dom_sf.
DR InterPro; IPR025561; KSR_SAM-like_dom.
DR InterPro; IPR002219; PE/DAG-bd.
DR InterPro; IPR000719; Prot_kinase_dom.
DR InterPro; IPR013761; SAM/pointed_sf.
DR InterPro; IPR046861; SAM_KSR1_N.
DR InterPro; IPR046933; SAM_KSR1_N_sf.
DR InterPro; IPR001245; Ser-Thr/Tyr_kinase_cat_dom.
DR InterPro; IPR008271; Ser/Thr_kinase_AS.
DR PANTHER; PTHR23257:SF775; KINASE SUPPRESSOR OF RAS 2; 1.
DR PANTHER; PTHR23257; SERINE-THREONINE PROTEIN KINASE; 1.
DR Pfam; PF07714; PK_Tyr_Ser-Thr; 1.
DR Pfam; PF13543; SAM_KSR1; 1.
DR Pfam; PF20406; SAM_KSR1_N; 1.
DR SMART; SM00109; C1; 1.
DR SMART; SM00220; S_TKc; 1.
DR SUPFAM; SSF57889; Cysteine-rich domain; 1.
DR SUPFAM; SSF56112; Protein kinase-like (PK-like); 1.
DR PROSITE; PS50011; PROTEIN_KINASE_DOM; 1.
DR PROSITE; PS00108; PROTEIN_KINASE_ST; 1.
DR PROSITE; PS00479; ZF_DAG_PE_1; 1.
DR PROSITE; PS50081; ZF_DAG_PE_2; 1.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transferase {ECO:0000256|ARBA:ARBA00022679};
KW Zinc {ECO:0000256|ARBA:ARBA00022833}.
FT DOMAIN 404..448
FT /note="Phorbol-ester/DAG-type"
FT /evidence="ECO:0000259|PROSITE:PS50081"
FT DOMAIN 635..901
FT /note="Protein kinase"
FT /evidence="ECO:0000259|PROSITE:PS50011"
FT REGION 226..293
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 492..551
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..519
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 520..541
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 922 AA; 104306 MW; 16571E5500DECC76 CRC64;
MNEEMTKSEE QHLSLQKALQ QCELVQNMID ISISSLEGLR TKCATSNDLT QKEIRTLEGK
LVKYFSRQLS CKCKVALEER SAELEDFPRL GHWFRIVNLR KEVTQEMSPG EVTLEGLLEM
SEEQVCELLQ KFGASEEECA RLNASLSCLR KAHQLGERSQ TKQDWSIQWP TSESGKENTP
VCQPEASQWI RFQLSQSPKV QSKYNQHMCH SPQALAPPLY ADRLTVDSPS SGLFPPLDSG
HRSLPPSPRQ RHFGHTPPRT HLVVNTMTPP GTPPMRRRNK VKAPGTPPPP SRKLIHLLPG
FTALHRSKSH EFQLGNRLDD TQTPKAKKKT KPLNLKIHSS VGSCENLPTQ RSPLHTERSL
RSFFFPSFIP STPPVHAETP SANTLSVPRW SPQIPRRDLG NSIKHRFSTK YWMSQTCIVC
GKGMLFGLKC KNCKLKCHNK CTKEAPPCHL LIIQRGGRES LKARLVRTES VPCDINNPLR
YTDLHISQTL PKTNKINKDH IPVPYQPDSS SNPSSTTSST PSSPAPPLPS SATPPSPLHP
SPQSARQQKQ FNLTDVAPEA PPSRAPQVIL HPVLSEPGYP QFNFALSQNE EGNDEDSGDE
FEEMNLSLLS ARNFPRKASQ TSIFLQEWDI PFEQLEIGEM IGKGRFGKVF HGRWHGEVAI
RLIDIERDNE DQLKAFKREV MAYRNTRHEN VVLFMGACMS PPHLAIITSF CKGRTLYSVV
RDAKVVLDVN KTRQIAQEMV KGMGYLHAKG ILHKDMKSKN VFYDNGKVVI TDFGLFTISG
VLQAGSRRED KLRIPNGWLC HLAPEIIQQL SPETEEDKLP FSKQSDVFAF GTIWYELHAR
EWPYKSQPAE VIIWQIGSGM KPNLAQTGMG KEILDILLLC WAYKPEERPS FSKLVDLLEK
LPKRNRRLSH PGHFWKSAEY VK
//
