ID   I3JXI7_ORENI            Unreviewed;       744 AA.
AC   I3JXI7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   17-JUN-2020, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   SubName: Full=Si:ch1073-459j12.1 {ECO:0000313|Ensembl:ENSONIP00000013582.2};
GN   Name=AEBP1 {ECO:0000313|Ensembl:ENSONIP00000013582.2};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013582.2, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000013582.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Secreted {ECO:0000256|ARBA:ARBA00004613}.
CC   -!- SIMILARITY: Belongs to the peptidase M14 family.
CC       {ECO:0000256|ARBA:ARBA00005988}.
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DR   AlphaFoldDB; I3JXI7; -.
DR   STRING; 8128.ENSONIP00000013582; -.
DR   Ensembl; ENSONIT00000013592.2; ENSONIP00000013582.2; ENSONIG00000010802.2.
DR   eggNOG; KOG2649; Eukaryota.
DR   GeneTree; ENSGT00940000158323; -.
DR   HOGENOM; CLU_006722_4_0_1; -.
DR   InParanoid; I3JXI7; -.
DR   TreeFam; TF315592; -.
DR   Proteomes; UP000005207; Linkage group LG12.
DR   GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR   GO; GO:0004181; F:metallocarboxypeptidase activity; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006508; P:proteolysis; IEA:InterPro.
DR   GO; GO:0032101; P:regulation of response to external stimulus; IEA:UniProt.
DR   CDD; cd00057; FA58C; 1.
DR   CDD; cd11308; Peptidase_M14NE-CP-C_like; 1.
DR   Gene3D; 2.60.40.1120; Carboxypeptidase-like, regulatory domain; 1.
DR   Gene3D; 2.60.120.260; Galactose-binding domain-like; 1.
DR   Gene3D; 3.40.630.10; Zn peptidases; 1.
DR   InterPro; IPR008969; CarboxyPept-like_regulatory.
DR   InterPro; IPR000421; FA58C.
DR   InterPro; IPR008979; Galactose-bd-like_sf.
DR   InterPro; IPR000834; Peptidase_M14.
DR   PANTHER; PTHR11532:SF48; ADIPOCYTE ENHANCER-BINDING PROTEIN 1; 1.
DR   PANTHER; PTHR11532; PROTEASE M14 CARBOXYPEPTIDASE; 1.
DR   Pfam; PF13620; CarboxypepD_reg; 1.
DR   Pfam; PF00754; F5_F8_type_C; 1.
DR   Pfam; PF00246; Peptidase_M14; 1.
DR   PRINTS; PR00765; CRBOXYPTASEA.
DR   SMART; SM00231; FA58C; 1.
DR   SMART; SM00631; Zn_pept; 1.
DR   SUPFAM; SSF49464; Carboxypeptidase regulatory domain-like; 1.
DR   SUPFAM; SSF49785; Galactose-binding domain-like; 1.
DR   SUPFAM; SSF53187; Zn-dependent exopeptidases; 1.
DR   PROSITE; PS00132; CARBOXYPEPT_ZN_1; 1.
DR   PROSITE; PS01286; FA58C_2; 1.
DR   PROSITE; PS50022; FA58C_3; 1.
PE   3: Inferred from homology;
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT   DOMAIN          18..175
FT                   /note="F5/8 type C"
FT                   /evidence="ECO:0000259|PROSITE:PS50022"
FT   REGION          1..26
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          639..663
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        639..657
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   744 AA;  84226 MW;  47CFDE3203617DB0 CRC64;
     KEAEERARNR PRVFKEPKKC PPLGLESHKV EPDQLSASSM SQYHFAPQRA RLNMQGSDDE
     DNIRGGAWCA NSEDAIHWFE IDARRATEFT GVITQGRDSL NDNDYVTSYF LAFSNDSREW
     TTIHDGYADW LFFGNNDKDT PVMNQLAVPV VARYMRIIPQ SWNGSLCMRL EVLGCPLPVN
     VLYRQNEVTP VDYLQFKHHS YSEMVDLMKS VNEECPNITT IYSLGRSSKG REIVAMIISG
     NPTEHEIGEP EIRFTAGLHG NEAVGREMIL LLMQYLCKEY KDRNPRAQRL VEGIRIHLVP
     SLNPDGQEEA FEAGSELSSW TTGHFTNEGF DIFQNFPDLN SILWDAEDKG MVPKLTPNHH
     VPIPEHFEAN SSIAVETRAI ISWMKSYPFV LGANFQGGER IVAYPYDSLR LNKPAETEGM
     QNEPRVTADE SLFRWLAISY ASTHLTMTHS HHGSCQGDTP GGGLGIVNRA KWKPVTGSMN
     DFSYLHTNCL ELSIFLGCDK FPHQSELAYE WEKNREAMLI FMEQVHRGIR GIVKDQQGNP
     IANATISIEG INHDVTTAPT GDYWRLLNPG EYRVTARAEG FSSLTKLCVV GYESGATACS
     FNLAKSNWDR IKQIMALHGN KPIRIAYSNS RVQYTTVNNG HRSVIGPSNG SSSNSRLSPE
     QRRKRKIALI RRLRQRKLMK AMSMRTTLPP TTTTTTTTIP TTTEATTSWY DSWVWGEGQS
     LLWMHIKKTV IYTIFTYGRN IFTV
//