ID I3JXS6_ORENI Unreviewed; 437 AA.
AC I3JXS6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE RecName: Full=Septin {ECO:0000256|PIRNR:PIRNR006698};
GN Name=LOC100710644 {ECO:0000313|Ensembl:ENSONIP00000013671.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000013671.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000013671.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Chromosome, centromere, kinetochore
CC {ECO:0000256|ARBA:ARBA00004629}. Cytoplasm, cytoskeleton, cilium
CC axoneme {ECO:0000256|ARBA:ARBA00004430}.
CC -!- SIMILARITY: Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like
CC GTPase superfamily. Septin GTPase family.
CC {ECO:0000256|PIRNR:PIRNR006698, ECO:0000256|RuleBase:RU004560}.
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DR AlphaFoldDB; I3JXS6; -.
DR STRING; 8128.ENSONIP00000013671; -.
DR Ensembl; ENSONIT00000013681.2; ENSONIP00000013671.2; ENSONIG00000010867.2.
DR GeneTree; ENSGT00940000154222; -.
DR InParanoid; I3JXS6; -.
DR OMA; VNYLERQ; -.
DR Proteomes; UP000005207; Linkage group LG7.
DR GO; GO:0000776; C:kinetochore; IEA:UniProtKB-KW.
DR GO; GO:0031105; C:septin complex; IEA:InterPro.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-UniRule.
DR GO; GO:0007049; P:cell cycle; IEA:UniProtKB-KW.
DR CDD; cd01850; CDC_Septin; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR030379; G_SEPTIN_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR016491; Septin.
DR InterPro; IPR008115; Septin7.
DR PANTHER; PTHR18884; SEPTIN; 1.
DR PANTHER; PTHR18884:SF115; SEPTIN; 1.
DR Pfam; PF00735; Septin; 1.
DR PIRSF; PIRSF006698; Septin; 1.
DR PRINTS; PR01742; SEPTIN7.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51719; G_SEPTIN; 1.
PE 3: Inferred from homology;
KW Cell cycle {ECO:0000256|ARBA:ARBA00023306};
KW Cell projection {ECO:0000256|ARBA:ARBA00023069};
KW Centromere {ECO:0000256|ARBA:ARBA00023328};
KW Chromosome {ECO:0000256|ARBA:ARBA00022454};
KW Cilium {ECO:0000256|ARBA:ARBA00023069};
KW Coiled coil {ECO:0000256|SAM:Coils};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134, ECO:0000256|RuleBase:RU004560};
KW Kinetochore {ECO:0000256|ARBA:ARBA00022838};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU004560};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 47..319
FT /note="Septin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51719"
FT COILED 339..424
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 437 AA; 50664 MW; 5CEEF02A3F46F75E CRC64;
SSLRGSATVA QKNSSNRFTK ARFQRNLEGY VGFANLPNQV YRKSVKRGFE FTLMVVGESG
LGKSTLINSL FLTDLYSKDY PGPSHRIKKT VQVEQSKVLI KEGGVQLTLT IVDTPGFGDA
VDNTIICSFW QPVINYIDSK CEDFLNAESR VNRRSMPDNR VHCCLYFIAP SGHGLKPLDI
EFMKRLHDKV NVIPLIAKAD TLTPEECHLF KKQIMKEIQE HKIKIYEFPD VDEDEDNKLV
RKIKEKMPLA VVGSNVVIEV NGKKVRGRQY PWGVAEVENG EHCDFTVLRN MLIRTHMQDL
KDVTNNVHYE NYRSKKLAAV TCNGVDTSKT KGQLTKSPLA QMEEERREHV MKMKKMEAEM
EQVFEMKVKE KKQKLKDSEA ELERRHEQMK RNLEAQYKEL EEKRRVFEEE KANWEAQQRI
LEQQKTMEKN KKKGKIF
//
