ID I3K0T7_ORENI Unreviewed; 4368 AA.
AC I3K0T7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 61.
DE SubName: Full=Apolipoprotein B-100 {ECO:0000313|Ensembl:ENSONIP00000014732.2};
GN Name=APOB {ECO:0000313|Ensembl:ENSONIP00000014732.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000014732.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000014732.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}. Lipid
CC droplet {ECO:0000256|ARBA:ARBA00004502}. Secreted
CC {ECO:0000256|ARBA:ARBA00004613}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00557}.
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DR RefSeq; XP_019204094.1; XM_019348549.1.
DR STRING; 8128.ENSONIP00000014732; -.
DR Ensembl; ENSONIT00000014744.2; ENSONIP00000014732.2; ENSONIG00000011699.2.
DR GeneID; 102079941; -.
DR CTD; 566465; -.
DR eggNOG; KOG4338; Eukaryota.
DR GeneTree; ENSGT00590000083139; -.
DR HOGENOM; CLU_000127_0_0_1; -.
DR InParanoid; I3K0T7; -.
DR OMA; PAFRINI; -.
DR OrthoDB; 5349904at2759; -.
DR TreeFam; TF331316; -.
DR Proteomes; UP000005207; Linkage group LG19.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-SubCell.
DR GO; GO:0005811; C:lipid droplet; IEA:UniProtKB-SubCell.
DR GO; GO:0005319; F:lipid transporter activity; IEA:InterPro.
DR GO; GO:0006629; P:lipid metabolic process; IEA:UniProtKB-KW.
DR Gene3D; 2.20.80.10; Lipovitellin-phosvitin complex, chain A, domain 4; 1.
DR Gene3D; 1.25.10.20; Vitellinogen, superhelical; 1.
DR InterPro; IPR015819; Lipid_transp_b-sht_shell.
DR InterPro; IPR009454; Lipid_transpt_open_b-sht.
DR InterPro; IPR011030; Lipovitellin_superhlx_dom.
DR InterPro; IPR015816; Vitellinogen_b-sht_N.
DR InterPro; IPR015255; Vitellinogen_open_b-sht.
DR InterPro; IPR001747; Vitellogenin_N.
DR PANTHER; PTHR13769; APOLIPOPROTEIN B; 1.
DR PANTHER; PTHR13769:SF1; APOLIPOPROTEIN B-100; 1.
DR Pfam; PF06448; DUF1081; 1.
DR Pfam; PF09172; Vit_open_b-sht; 1.
DR Pfam; PF01347; Vitellogenin_N; 1.
DR SMART; SM01169; DUF1943; 1.
DR SMART; SM00638; LPD_N; 1.
DR SUPFAM; SSF48431; Lipovitellin-phosvitin complex, superhelical domain; 1.
DR PROSITE; PS51211; VITELLOGENIN; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW LDL {ECO:0000256|ARBA:ARBA00022710};
KW Lipid metabolism {ECO:0000256|ARBA:ARBA00023098};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW Transport {ECO:0000256|ARBA:ARBA00022448}.
FT SIGNAL 1..18
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 19..4368
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025372213"
FT DOMAIN 36..650
FT /note="Vitellogenin"
FT /evidence="ECO:0000259|PROSITE:PS51211"
SQ SEQUENCE 4368 AA; 488816 MW; 913F487BF8B615F5 CRC64;
MAHRKLCLLL LLSCCARAQD EQDVDQQTPA CQSSRFKAFR KYVYRYSTES RNSVTGAADL
RDGHALTCQV EVEVPHLCKF IMHTRGCTLR PAPSSDAFQA AMERNPLKFT LQGVSNIQLY
PEADEAIGIL NIKRGIVSAL MVPDVEEQQG SRTSTVHGQC VTLVNSSSDV ATGVTLVRDL
SQCDQFYSRE LTNSPLALLQ RLHSPMSKLI TSTQSCSYQF DRRERHITTA SCTENHSYLP
LSHTDSTVSS ELTQELRFQS NRRTSNRDFS VERDQVRPLH FEDPEDKSPV QTGEDVLTTL
RELVTLAGTD QGQKRAGLFH KLVSGLRALR NETLSRAVPE MRAASGWLTW QALFQCGTSE
CTSAILQIIR TIDGVSLETD ALVYALSLQA DPDAARVRDM LSMAQYKQSK PIMYALANTV
KKFHKNAVMP EVTDVLTDVS KFMEVLLNDC SVPHYDSDLP PDPAEMSFLV LRVVGVMGQA
MQAVSPSLIS SILRCAKKAE VPLSHQKAAI QAFRLMDVSD EVRDVFMEVY RDDQSPVEKR
VAAFLILMKS PDRATIRDIV SSLENTRDEQ LRSFVVSYLN NIRNSDGPQI QQLREYTELA
LNGQLSPTGA IFDGMSRNYK LDSSLGSIQS SIIFDGSDTL HKEMMLETTL KVFDYSYDIF
EVGVEGTGFE PTIDALFGER GFFPESMSRL MYLAQDKAPI LKAILDRIAP QRDRRKRQIP
EDFLKDMADS IQRLVNDVSS SPAPEATAYL RLLGNEIGYL KTGEMRKMFE TLFMYYHVFI
RVLPAQVFSE LISRTDNEVF AHYIFMENAF ALPTASGFPL KFSLAGVFAP GVRGGLTPSA
ATELSFMPSV GLEFITQMGV HIPDYVDAGI QMHTNMYHES SLNAKATVNR RQVKLSIPAP
QSNTQLFSVS TKVLSLSSGQ TTTGPCRDRT DSVDCQPLFS GLKLCTGVRY SNPTSVDQAP
CSPLTGETRF AVEIQPTGTV SEYTATITDE TVREGKRGRH KVETLKLTLK AEGDDSSEAS
AALKYNRLKN TVSAEVVIPD YDVEAGVKLV LTESGAERKM RGITVDITNK NIPQLTLVGR
ARLSMMNDGM LQLQMVVPSL KADASLTANL KKDEDVVMDL ETIVHLSEIS YQQKASLKYD
NDKFEVELKS DLNSETQKMI PNVEDHRRQL QQLIDEILDQ RVAQTDMKLR HIITKGIEAG
NIWLDKLTAR IPTLAKLRSK RSLSDLTLPA LPEKLFLQSD TLFRYQFNKD KMAISLPLPL
GGKKSEELNV PNSLSVPLID LPQIGLYIPP RAYQLPRFTI PPSLDLSLPL LGLAEASTKI
SSNFYSWEGS ISGGNITADV PSYTAQFRAM AQSPFSLLSY KLEGTGMMSG RGDDNLKYLL
NSSFSHSLID TSVSVLETLR VTDKLKARAN YKMEASSALG LQATLYYSAH ATSSLNSDEV
SGDGTVNGLL KIGSFHTNGS YLHSYNLRPL DREGRGESTL QFDSPVLQVH NTVRGVCKNS
ELYIMSQTRA QRDMLQHVAE LRYKDAQLTL KCSALAKAMG ESLSNQVEFG VSNQMALLTI
ESQAYDDKNR VYSLISGSLD SNGLQVNSEG SLTFETGRVW HKASVTAGKN GLTTSGINSI
QCSPVTVENV FNCAIDSGGA SLSSTTKAMG DESRGELKIE GEVTAAKASL YGDLKGYAYD
ATTLSSVKMM LDRRALSFTG NTKGTLRQMK TENSHTLTLT LWTLSLRSES NNFICDDIYY
KQDTKLDVKP FFTRFNMRND LRFYDIALNH EGHVRLEPVK VALRGSMTAA YREQHSVKHT
YELTYDSPMA GTMKYSTSGN VMDAQLSHSC ELEFAGLSLT SDCEAQVNSA PVRFNSSVRT
MALPFRLTVD AGFNAAGEMN LRGQHTGDTY SQLLLKAEPL ALSFAHKSGI STAHKLPSGE
SSAGLKNIFE GFLTPSDQLL SWEVKSKLND RAYNQATSIS NNPEKAELEF SAVMLEDLRE
NAKFNMSGFL QYDKNNDCHI IKIPLIKSFP AAFQQLKNTL VQTLESLQQV IRDVDIDGLI
SNFREKLERL PTQVSNFMQE LELENKVNQV KVKLDDWIGA SAVTMNDLEL AVKNLRKNLE
TTVTDIITKI QKLVFSVEEY IKGGRLEAQI TNVLSDVGNH MWAFDDQYKI KRSFLRVLDI
IEDIMKQIDF QKLRISGAVF LQELDSKYEI LETIKTKLSE LKRVIEDFNI KSIFEDLKEY
LLSIDWAAYV EQLSYNIPPS EIAKVMESIH DVIVNWIDEY EIPNKINEVY FYTRDLVLKY
DLDDIFKQLM DQVVILVEQF KIEKTVQTLV EALKSVKFEY IYDKIMQFLS SVTNQLRAID
FKKSIDDLNE YISSTLKSMR TFWYGAFVDD ANKKIAELTN YINEQIKIYE LVKKIEAVRD
FFREIQTSIF TYLDELKNTK VADALKRLKN VIDTTFYNDI KLKVQDILED ARERIVDMDI
RGELYLFLER ASESYRNIVE LMSAKFNQMM EQIVKTAKDN EFINQTKQAV DELLSLLKRG
KIEVPTFTVP LTDLVIQGFT VDMKNLQDIS IPAQISLPRF TILNLFTIPG FTIDVDELKA
RIIALIDEIR DFEIQTPDPE EIFGDLKVLY LSELPDLTFP EITLSEITFP AINIPKLQWR
GFDVLTRPIP EITYPRIPSD ICVPRFGKLH GEFRVYSEDL TLVTTGKIEN STSTPKNPQF
TATVASHAKS HFKPLEYTFE VTAQLEAPRM KKLQFTETLK AAHMAFAIDH EGSLTLTGTA
AEASAKTVAR AATQMYTADL VSKMDLTLKS GVHAAVATTY NHSLNIPSHE TSSQASVRQN
IAASAESGRV TVTGETTGNG KWSIYDYADE GTHKSNMEFD VNFSTAKLTF VGETDCEALK
AKHTLRAESV LLNRISIDAK CETEIPSVKK SVLVLDGVAD IGDLKVALTA YHDVEFNGKL
TGSMSNSLEF TIHPFEVAFD VKNKVNSKVF FPLRLTGKVA LQHDCGVALN SVKQHVSCFA
LARFNQYKYS HNITAENNDM DIFFHSSAIG EANLEFLTIP LSIPEMTIPY FQVKTPEVRE
FPLWENAGFQ TLLTTPQQSF DMNLKLHYYK NPDTHSFELY LKPIYGAISD KATVLQAQFE
EFRDKVVAFL KDSYNQARPQ YIKHRTDTSS LPPSIFRVPG YKIPILDIQV SPFRAEMPAF
SYFIPKEVRT PSFKVPALGF SVPSYTLVLP LLKFAVIHVP ETLSEVTLPT FRLPRMQNNI
AIPAMGNMTF DFSFKSAVIS FIASAGLYNQ SDIVARFGTS STSAFDILNI KIDGTSSLTR
TRGIKVASAV SLEHDNINAN HECAVNLNKR GMEASLTNTA KVKLPFLNLE LNQELIGNTK
TKTNLASKKK LKYIFSIPLI EAAGNFDMNW ELEALPSYVS LETCTQGKTD ITMVNGCNFS
GDLENKASFY FTANSLRSTV KTVLNSNLDK QEKQKRNSNN IFLFDLNKEL ALAVSLQRIF
ATAECTSTNN VDLAFFTTNG KHVAKGELDF IPLTTFKTKL NLEASQPSSL GDARLIQSIN
LAISSEKQSL TWRVKEQLAS FVHAHHLLLS NDESAVRLDL AGSVEGPLAF LKTVKIPVYQ
NTLWDVLRFD QVTSMNKLQF LNVSTSIVYT KSMDGHEYAI PFTLLENGVT FSVPQISIAV
PSWLKGIPSS VRNIDERLEN PDVPDHLTLP PVISVPAFNV PFTTLHVEPF TLDPKNLSIP
RVISTEAFEI MLPGLPVLSV PGYDINTEYL QGKTSFLSFK IPQYEITVLP FTLPKSVTIG
EQTISLNYIA RQISNFDLPA ITIPEQRIEI PATTLHLPSS VFIPSFGALS VSVKVSSPIY
SVLTTSSVEK KDSDLLTSLK SRCVSTMNFL EYDLSADATM GYDNGAMSLT GKGKLIHSDG
NVNWQHVLAQ NVRMKRQVSA AESLEPRHTL SVDISSRTFT DVSFRFASRK DGITASVSSP
SSGFLGVHLQ RRSPSQLYGK LFSRYLSSPE RDTDVFAAKV SLRNSQKFIV QTSWNRDFLW
DVMEGTKHRV PAMTDAVFKC INKYHTSHFG FDINRGSKKL KNTLSYAIER AYDEVPVSCT
TLQDWVQNFA DGARDNYRKA SDVLMSMSVQ DAIDRLFETV KRVMKQCENN MNVLLHAALQ
FLNDTRFMVP GSERKLSLME AVQEARSAIQ RINSLVENIS TDMRKIRFAV PGSDAFVSGD
EIMDKVGNIL DQLREGVIRV INVLHLTAAG CLRVVAEKAE SFLAYLQDQN SEISSKVDAI
YADVLQFSEQ HSEEAQRCTT EYRDLIKLKT QKALNALSME RVNDGTSRII SILQVRFYEG
LDAGVAVMTR VSQSTAPYVR VSDKKMDIEI PLPFLWRSFS EWPTPLRQ
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