ID I3K457_ORENI Unreviewed; 2924 AA.
AC I3K457;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Neurobeachin a {ECO:0000313|Ensembl:ENSONIP00000015902.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000015902.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000015902.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8128.ENSONIP00000015902; -.
DR Ensembl; ENSONIT00000015917.2; ENSONIP00000015902.2; ENSONIG00000012634.2.
DR eggNOG; KOG1787; Eukaryota.
DR GeneTree; ENSGT00940000154934; -.
DR HOGENOM; CLU_000218_2_0_1; -.
DR InParanoid; I3K457; -.
DR OMA; XRKVEIM; -.
DR TreeFam; TF313490; -.
DR Proteomes; UP000005207; Linkage group LG10.
DR GO; GO:0016358; P:dendrite development; IEA:Ensembl.
DR GO; GO:0007416; P:synapse assembly; IEA:Ensembl.
DR CDD; cd06071; Beach; 1.
DR Gene3D; 2.60.120.200; -; 1.
DR Gene3D; 1.10.1540.10; BEACH domain; 1.
DR Gene3D; 1.25.10.10; Leucine-rich Repeat Variant; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 1.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR011989; ARM-like.
DR InterPro; IPR016024; ARM-type_fold.
DR InterPro; IPR000409; BEACH_dom.
DR InterPro; IPR036372; BEACH_dom_sf.
DR InterPro; IPR013320; ConA-like_dom_sf.
DR InterPro; IPR046851; NBCH_WD40.
DR InterPro; IPR010508; NBEA-like_DUF1088.
DR InterPro; IPR031570; NBEA/BDCP_DUF4704.
DR InterPro; IPR046852; Neurobeachin_a-sol.
DR InterPro; IPR023362; PH-BEACH_dom.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR InterPro; IPR036322; WD40_repeat_dom_sf.
DR InterPro; IPR001680; WD40_rpt.
DR PANTHER; PTHR13743; BEIGE/BEACH-RELATED; 1.
DR PANTHER; PTHR13743:SF62; NEUROBEACHIN; 1.
DR Pfam; PF02138; Beach; 1.
DR Pfam; PF06469; DUF1088; 1.
DR Pfam; PF15787; DUF4704; 1.
DR Pfam; PF13385; Laminin_G_3; 1.
DR Pfam; PF20426; NBCH_WD40; 1.
DR Pfam; PF20425; Neurobeachin; 1.
DR Pfam; PF14844; PH_BEACH; 1.
DR SMART; SM01026; Beach; 1.
DR SMART; SM00320; WD40; 5.
DR SUPFAM; SSF48371; ARM repeat; 1.
DR SUPFAM; SSF81837; BEACH domain; 1.
DR SUPFAM; SSF49899; Concanavalin A-like lectins/glucanases; 1.
DR SUPFAM; SSF50729; PH domain-like; 1.
DR SUPFAM; SSF50978; WD40 repeat-like; 1.
DR PROSITE; PS50197; BEACH; 1.
DR PROSITE; PS51783; PH_BEACH; 1.
PE 4: Predicted;
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW WD repeat {ECO:0000256|ARBA:ARBA00022574}.
FT DOMAIN 2160..2269
FT /note="BEACH-type PH"
FT /evidence="ECO:0000259|PROSITE:PS51783"
FT DOMAIN 2253..2541
FT /note="BEACH"
FT /evidence="ECO:0000259|PROSITE:PS50197"
FT REGION 1..53
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 980..1033
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1228..1331
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1528..1550
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1654..1746
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1851..1872
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1..49
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 988..1002
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1009..1024
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1256..1272
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1300..1316
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1530..1550
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1710..1746
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 2924 AA; 323566 MW; 5AFFBD3A5A2113A6 CRC64;
MSSEKPVSAP PGSASSLTDT DRESHPPAGS SAQQPPPPQQ QQQVAAGAGS GTTGDRMVSA
AGSMVLPAGV INPAVPIRNI QMKFAVLVGL IQVGEVSNRD IVETVLNLLV GGEFDLEMNF
IIQEAESIGC MVELLSHCEV TCQAEIWSMF TAILRKSVRN LQTSTEVGLI QQVLLKMSTV
DDMIADLLVD MLGVMASYSI TVKELKLLFS MLRGENGIWP RHAIKLLSVL NQMPQRHGPD
TFFNFPGRSA AAIALPPIAK WPYQNGFTIN TWFRQDPLNN INVDKDKPYL YCFRTSKGIG
YSAHFVGNCL IVTSLKSKGK GFQHCVKYDF QPRKWYMISI VHIYNRWRNS EIRCYVNGQL
VSYGDMAWHV NTNDSYDKCF LGSSETADAN RVFCGQLGAI YVFSEALNPA QIFAIHQLGP
GYKSTFKFKS ESDIHLAEHH KQVLYDGKLA SSISFTYNAK ATDAQLCLES SPRENPSIFV
HSPHALMLQD VKAIVTHSIH SAIHSIGGIQ VLFPLFAQLD YKQLNDSSVD TTVCATLLAF
LVELLKSSVA MQEQMLGGKG FLVIGYLLEK SSRVHITRAV LEQFLSFAKY LDGLPHGAPL
LKQLCDHVLF NAAIWIHTPA KVQLSLYTYL SSEFIGTATI YTTIRRIGTV LQLMHTLKYY
YWAINPLECS GITPKGLDGP RPSQKEIISL RAFMLLFLKQ LILKDRGVKE DELQSILNYL
LTMHEDENIH DVLQLLVALM SEHPASMIPA FDQRNGIRVI CKLLASKSES IRVQALKVLG
YFLKHLGHKR KVEIMHTHSL FTLLGERLMM HTNTVSITTY NTLYEILTEQ VCTQVVHKPH
PDPDSTVKIQ NPMILKVVAT LLKNSSPSVE LMEVRRLFLS DMIKLFSNSR ENRRCLLQCS
VWQDWMFSLG YINPKNPEEQ KITEMVYNIF RILLYHAIKY EWGGWRVWVD TLSIAHSKVT
YEAHKEYLAK MYEEYQRQEE ENMKKGKKGS VSTISGLSAT PAPVVNGNLE IDDNSQTQTP
ESEAEYSEGA AADSRNLLAE GAVKRPNGET LTPGEQSAGP GVRVEVHDLL VDIKAEKVEA
TEVKLDDLDL SPEGLGGSVG GGGGGGMENG PLVEVDSLLD SAYCSVVQNL NGNLAPKDDT
SGSGVGMGTN LGLSGVSLDD DGNMGPLITL ADEKDSVPSN NGFLFSKVGL VLLCWFLSFL
VLFTLPNNVS NASDDLSLLA HMTSCGSDLT QTQSHTTGEL PEDGPFKIQS PLADISSIAE
AESQTQGTSR PDFPEGEGTA GADAETAGLK TGGDTASTTS DTERSDDGKD KDTKKIQTTA
TTQALHGRTA AQLERDLRVD LGFRGMPMTE EQRRQFSPGP RTTMFRIPEF KWSPMHQRLL
TDLLFALETD VHVWRSHSTK SVMDFVNSNE NIIFVHNTIH LISQMVDNII IACGGILPLL
SAATSPSTEL ENIEATQGMS SETAVTFLSR LMAMVDVLVF ASSLNFSEIE AEKNMSSGGL
MRQCLRLVCC VAVRNCLECR QRQRDRSCKS SLTSSKSQDS LHSASTASKV QDPDRLLQDV
DINRLRAVVF RDVDDSKQAQ FLALAVVYFI SVLMVSKYRD ILEPQREIGR STSLSGRSIR
HEINSPTSTG DLCFSFAPSS STCNHFFLKH PSTAFSDRDK QTPTPVDDSP RAGLPHTDSG
IGEEGHVSGS LNGSEMGGSG GGGTDLLCSL SSDVRRSQES LLDSPHNPGS TPNTSQAPPS
SISSISQTNK GINVKEILKS LVAAPVDGGD LGQESGPTPY HPDPALKTHP MLPMQFHSFD
RSVVVPVKKP PPGSLSVNTV GTPTTSGGAS AGSTPNIFAA ATATPKSMIN TTGAADSASS
SSSSSSSFVN GATSKNLPAV QTVAPMPEDT MENMSITTKL ERALEKVAPL LREIFVDFAP
FLSRTLLGSH GQELLIEGLV CMKSSTSVVE LVMLLCSQEW QNSIQKNAGL AFIELINEGR
LLCHAMKDHI VRVANEAEFI LNRQRAEDVH KHAEFESNCA QYAADRREEE KMCDHLISAA
KHRDHVTANQ LKQKILNILT NKHGAWGTMS QSQLHDFWRL DYWEDDLRRR RRFVRNAFGS
THADVLLKAL DEYSTEDEEK GLKKKNFRSQ SVVTQNPEAE LMLEGDDDAV SLLQEKEIDN
LAGPVVLSTP AQLVAPVVVA RGTLSITTTE IYFEVDEEDT AFKKMDPKVL AYSEGLHGKW
MFSEIRAVKS PDLPRVGVGT SYGLPQARRI SLATPRQLFK SSNMTQRWQR REISNFEYLM
FLNTIAGRTY NDLNQYPVFP WVLTNYDSEE LDLTLPGNFR DLSKPIGALN PKRAAFYAER
YETWDDDSAP PHHYTTLYST AHSTLMWMLR IEPFTTFFLS ANDGKFDHPE RAFSGIGRSW
RNCQRDTADV KELIPEFYYL PEMFVNSNEY ELGMREDAVP VSDVELPVWA KKPEDFVRIN
RMALESEFVS CQLHQWIDLI FGYKQRGPEA VRALNVFNFL SYEGAVTLDN LDAVQRELIE
AQIQLCGQVP SQLLIEPHPP RSSAMHLCFL PQSPLMFKDQ MQQDVIMVLK FPSNSPVTHV
AANTLPHLSI PAAVTVTCSR LFAVNRWHNT VGLRGAPGYS LEQAHHLPIE MDPLIANNSG
VNKRQITDLV DQSIQINTHC FVVTADNRYI LVCGFWDKSF RVYSTETGKL TQIVFGHWDV
VTCLARSESY IGGDCYIVSG SRDATLLLWY WSGRHHIIGD NPNNSDYPAP RAVLTGHDHE
VVCVSVCAEL GLVISGAKEG PCLVHTITGD LLRALEGPEL CQQPRLISVS SEGHCIIYYE
RGRFCNFSIN GKLLAQMEVN DSTRAILLSS DGQNLVTGGD NGVVEVWQAC DFKQLYIYPG
CDAGIRAMDL SHDQRTLITG MASGSIVAFN IDFNRWHYEH QNRY
//
