ID I3K8M3_ORENI Unreviewed; 804 AA.
AC I3K8M3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 49.
DE SubName: Full=ADAMTS like 2 {ECO:0000313|Ensembl:ENSONIP00000017468.2};
GN Name=ADAMTSL2 {ECO:0000313|Ensembl:ENSONIP00000017468.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000017468.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000017468.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3K8M3; -.
DR Ensembl; ENSONIT00000017483.2; ENSONIP00000017468.2; ENSONIG00000013894.2.
DR GeneTree; ENSGT00940000159447; -.
DR HOGENOM; CLU_000660_6_1_1; -.
DR Proteomes; UP000005207; Linkage group LG12.
DR GO; GO:0005576; C:extracellular region; IEA:UniProtKB-KW.
DR GO; GO:0030198; P:extracellular matrix organization; IEA:InterPro.
DR Gene3D; 2.60.120.830; -; 1.
DR Gene3D; 2.20.100.10; Thrombospondin type-1 (TSP1) repeat; 5.
DR InterPro; IPR013273; ADAMTS/ADAMTS-like.
DR InterPro; IPR010294; ADAMTS_spacer1.
DR InterPro; IPR010909; PLAC.
DR InterPro; IPR000884; TSP1_rpt.
DR InterPro; IPR036383; TSP1_rpt_sf.
DR PANTHER; PTHR13723; ADAMTS A DISINTEGRIN AND METALLOPROTEASE WITH THROMBOSPONDIN MOTIFS PROTEASE; 1.
DR PANTHER; PTHR13723:SF281; NO LONG NERVE CORD, ISOFORM C; 1.
DR Pfam; PF05986; ADAMTS_spacer1; 1.
DR Pfam; PF08686; PLAC; 1.
DR Pfam; PF19030; TSP1_ADAMTS; 4.
DR Pfam; PF00090; TSP_1; 1.
DR PRINTS; PR01857; ADAMTSFAMILY.
DR SMART; SM00209; TSP1; 5.
DR SUPFAM; SSF82895; TSP-1 type 1 repeat; 5.
DR PROSITE; PS50900; PLAC; 1.
DR PROSITE; PS50092; TSP1; 5.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157,
KW ECO:0000256|PIRSR:PIRSR613273-3};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Secreted {ECO:0000256|ARBA:ARBA00022525};
KW Signal {ECO:0000256|ARBA:ARBA00022729}.
FT DOMAIN 762..800
FT /note="PLAC"
FT /evidence="ECO:0000259|PROSITE:PS50900"
FT DISULFID 49..90
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 53..95
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
FT DISULFID 64..80
FT /evidence="ECO:0000256|PIRSR:PIRSR613273-3"
SQ SEQUENCE 804 AA; 89815 MW; 96F48E42F1DFE75B CRC64;
CLNKRRHSHR PQLMLLVHIR NDGVASNSLE EQLEVTTYWW GEWAKWTACT RTCGGGVMSQ
ERHCLKQRKK AAAGKDNMTC TGTAKKYHLC NTKECPPTGR SFREEQCWSF NSQRYNGRNY
QWKPLYPDDY VHISSNPCDL HCTTTDGQRQ LMVTARDGTS CKYSSYRGVC VDGKCEPIGC
DGVLFSSNTL DKCGVCQGDG SSCSRVTGNF RRGPSTLGYS FITQIPEGSW DIQIIERKKL
ADVLAVTDQA GNFFFNGAYK VDSPQNFHAA GTVFKYRRPM DVYETGIEYI VAKGPIDQPI
NILVWNQNGR TPYITYEYTV LRDSLPPVPP PPVYTGSDTS AGEASVEVSG LLAPNGSICD
QVAPGGQMET EGTDGQKGKE TNEVYEETAA IDCEDGVATP KFTGGDYKNL KLSPADMYRW
KLSSQEPCSM TCSIGMSFVT CVRYDGVEVH DMYCDALTRP EPVHDFCIGR ECQPRWEASS
WSECSRTCGE GFQFRQVRCW KMLSPGLDSS VYSDLCTMAD LERPVERRAC KSPACGPQWE
VAEWMECPAK CGRKAQVARD VRCSDETRPC DPLTKPPNVK NCTGPPCERH WTVSEWGPCS
GSCGQGKMVR HVYCKAPEGR VVPENQCSAE NKPLAIHPCG DRDCAPHWLS QDWERCNTTC
GRGVKRRIVL CVGISGGKFQ IFDEEACVGN EKPEEENTCF ERPCFKWYTT PWSECTKTCG
IGVRMRDVKC YQGRELVRGC DPLTKPVAKQ TCTLQPCPTE PPDESCQDRP STNCLLALKV
NLCSHWYYSK ACCHSCRAVR PPAS
//
