ID I3KBB2_ORENI Unreviewed; 1437 AA.
AC I3KBB2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Plexin A3 {ECO:0000313|Ensembl:ENSONIP00000018407.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000018407.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000018407.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR STRING; 8128.ENSONIP00000018407; -.
DR Ensembl; ENSONIT00000018424.2; ENSONIP00000018407.2; ENSONIG00000014622.2.
DR eggNOG; KOG3610; Eukaryota.
DR GeneTree; ENSGT01050000244850; -.
DR HOGENOM; CLU_001436_2_0_1; -.
DR InParanoid; I3KBB2; -.
DR OMA; CTHRLAP; -.
DR TreeFam; TF312962; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0017154; F:semaphorin receptor activity; IEA:InterPro.
DR GO; GO:0016043; P:cellular component organization; IEA:UniProt.
DR GO; GO:0007399; P:nervous system development; IEA:UniProt.
DR CDD; cd00603; IPT_PCSR; 1.
DR CDD; cd01180; IPT_plexin_repeat1; 1.
DR CDD; cd01179; IPT_plexin_repeat2; 1.
DR CDD; cd01181; IPT_plexin_repeat3; 1.
DR CDD; cd12790; RasGAP_plexin_A; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 5.
DR Gene3D; 2.130.10.10; YVTN repeat-like/Quinoprotein amine dehydrogenase; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR002909; IPT_dom.
DR InterPro; IPR031148; Plexin.
DR InterPro; IPR013548; Plexin_cytoplasmic_RasGAP_dom.
DR InterPro; IPR046800; Plexin_RBD.
DR InterPro; IPR002165; Plexin_repeat.
DR InterPro; IPR016201; PSI.
DR InterPro; IPR008936; Rho_GTPase_activation_prot.
DR InterPro; IPR036352; Semap_dom_sf.
DR InterPro; IPR041019; TIG1_plexin.
DR InterPro; IPR041362; TIG2_plexin.
DR InterPro; IPR015943; WD40/YVTN_repeat-like_dom_sf.
DR PANTHER; PTHR22625; PLEXIN; 1.
DR PANTHER; PTHR22625:SF32; PLEXIN-A3; 1.
DR Pfam; PF08337; Plexin_cytopl; 1.
DR Pfam; PF20170; Plexin_RBD; 1.
DR Pfam; PF01437; PSI; 3.
DR Pfam; PF01833; TIG; 4.
DR Pfam; PF18020; TIG_2; 1.
DR Pfam; PF17960; TIG_plexin; 1.
DR SMART; SM00429; IPT; 4.
DR SMART; SM00423; PSI; 3.
DR SUPFAM; SSF81296; E set domains; 4.
DR SUPFAM; SSF48350; GTPase activation domain, GAP; 1.
DR SUPFAM; SSF103575; Plexin repeat; 2.
DR SUPFAM; SSF101912; Sema domain; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|ARBA:ARBA00022729};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 782..808
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 55..105
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 202..249
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 350..403
FT /note="PSI"
FT /evidence="ECO:0000259|SMART:SM00423"
FT DOMAIN 404..499
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 500..586
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 588..688
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT DOMAIN 690..785
FT /note="IPT/TIG"
FT /evidence="ECO:0000259|SMART:SM00429"
FT COILED 812..854
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 1437 AA; 161407 MW; 19E9DE339F5A6ED7 CRC64;
EIFCIRKGVV LRMFPFSYLT VVEGKPILRD MVFSPDHQYI YLLSDRQVSR LPVESCEQYS
SCSDCLGSGD PHCGWCVLFN KCSRQEACDK WEEPQHFNIQ LDQCVNISVS PSSMSVTSPA
MQLTIQVQNV PALSGGVTCV FEDLSNAPGE VRAKGQVMCM SPSLRDLPAQ THSFGAKRVV
QLSLRSTETG HQFITTNLIY YNCSVLNSCT SCVSSEFPCH WCKYRHICTN NLQDCSFQEG
RVSNMEGCPQ IIPTSDILVP AGMVRPITLR ARNLPQPQSG QKNYECVFNI QGKVQRIPAV
RFNSSCIQCQ NTSYWYEGDE AGDLPVDFSI VWDGDFFIDK PASMKALLYK CEAQRPSCGQ
CLKAPTAFEC GWCTESRKCL LRQHCPSPEQ NWMHYTRHNL RCSHPRITKI SPVTGPREGG
TRVTIEGENL GLQVKEIAHV QVAGVRCNPI PSQYISAERI VCDMAEALLP HSPGGRVEVC
IGLCNEEYRA FSSDTYAFVS PTFSRVHPAK GPVSGGTRLT VVGRHLNAGS SVTVYINKEE
CLFVTRIERE IVCITPGSAS GTGEAPIRLK IDRAEVTSTD TKYTYTDDPT ITSIEPNWTI
LNGSTLITVT GTNLRTIQEP KVRAKYGGVE TNNYCTVVND STMTCLAPGL VYTKPDPPEG
ALRPDEFGFI FDQVSSLLVL NSTPFTHYPN PTFDSLGNSG ILEVKPGSPI ILKGKNLIPP
APGNNRLNYT VLIGESPCLL TVSENQLLCD SPDITGEKRV VILVGGLEYS PGMLHIYSDS
ALTLPAIIGI GAGGGVLLIA IIAVLIAYKR KTRDADRTLK RLQLQMDNLE SRVALECKEA
FAELQTDIQE LTNDMDGVKI PFLEYRTYTM RVMFPGIEEH PVLKELDSPA NVEKALRLFS
QLLNNKMFLL TFIHTLEAQR SFSMRDRGNV ASLLMAALQG RMEYATVVLK QLLADLIEKN
LENRNHPKLL LRRTESVAEK MLTNWFTFLL HRFLKECAGE PLFMLYCAIK QQMEKGPIDA
ITGEARYSLS EDKLIRQQID YKQLTLMCIP PEGEVGTEVP VKVLNCDTVT QVKDKLLDAV
YKGIPYSQRP QADDMDLEWR QGRLTRIILQ DEDVTTKIES DWKRLNTLAH YQVTDGSVVA
LVQKQVSAYN IANSFTFTRS LSRYESLLRT SSSPDSLRSR APMITPDQET GTKLWHLVKN
HEHSDQREGD RGSKMVSEIY LTRLLATKGT LQKFVDDLFE TVFSTAHRGS ALPLAIKYMF
DFLDEQADKR QITDPDVRHT WKSNCLPLRF WVNVIKNPQF VFDIHKSSIT DACLSVVAQT
FMDSCSTSEH RLGKDSPSNK LLYAKDIPNY KSWVERYYRD IAKMPSISDQ DMDAYLVEQS
RLHGNEFNTL SALSELYFYI NKYKEEILTA LDRDGYCRKH KLRHKLEQAI NLMSGSS
//
