ID I3KJG6_ORENI Unreviewed; 1665 AA.
AC I3KJG6;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE SubName: Full=Roundabout, axon guidance receptor, homolog 1 (Drosophila) {ECO:0000313|Ensembl:ENSONIP00000021261.2};
GN Name=ROBO1 {ECO:0000313|Ensembl:ENSONIP00000021261.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021261.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021261.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR STRING; 8128.ENSONIP00000044675; -.
DR Ensembl; ENSONIT00000021280.2; ENSONIP00000021261.2; ENSONIG00000016868.2.
DR eggNOG; KOG4222; Eukaryota.
DR GeneTree; ENSGT00940000154477; -.
DR HOGENOM; CLU_003227_3_0_1; -.
DR TreeFam; TF351053; -.
DR Proteomes; UP000005207; Linkage group LG14.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR GO; GO:0008046; F:axon guidance receptor activity; IEA:InterPro.
DR GO; GO:0016199; P:axon midline choice point recognition; IEA:InterPro.
DR GO; GO:0035385; P:Roundabout signaling pathway; IEA:InterPro.
DR CDD; cd00063; FN3; 3.
DR CDD; cd07693; IgC_1_Robo; 1.
DR CDD; cd05725; IgI_3_Robo; 1.
DR CDD; cd05726; IgI_4_Robo; 1.
DR CDD; cd20952; IgI_5_Robo; 1.
DR Gene3D; 2.60.40.10; Immunoglobulins; 8.
DR InterPro; IPR003961; FN3_dom.
DR InterPro; IPR036116; FN3_sf.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR013098; Ig_I-set.
DR InterPro; IPR003599; Ig_sub.
DR InterPro; IPR003598; Ig_sub2.
DR InterPro; IPR013106; Ig_V-set.
DR InterPro; IPR032986; Robo1_Ig-like3.
DR PANTHER; PTHR44170; PROTEIN SIDEKICK; 1.
DR PANTHER; PTHR44170:SF9; ROUNDABOUT GUIDANCE RECEPTOR 1; 1.
DR Pfam; PF00041; fn3; 3.
DR Pfam; PF07679; I-set; 3.
DR Pfam; PF13927; Ig_3; 2.
DR SMART; SM00060; FN3; 3.
DR SMART; SM00409; IG; 5.
DR SMART; SM00408; IGc2; 5.
DR SMART; SM00406; IGv; 3.
DR SUPFAM; SSF49265; Fibronectin type III; 2.
DR SUPFAM; SSF48726; Immunoglobulin; 5.
DR PROSITE; PS50853; FN3; 3.
DR PROSITE; PS50835; IG_LIKE; 5.
PE 4: Predicted;
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunoglobulin domain {ECO:0000256|ARBA:ARBA00023319};
KW Membrane {ECO:0000256|ARBA:ARBA00022989};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022989};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989}.
FT DOMAIN 44..140
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 146..233
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 238..322
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 327..422
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 431..511
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
FT DOMAIN 539..633
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 652..749
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT DOMAIN 754..850
FT /note="Fibronectin type-III"
FT /evidence="ECO:0000259|PROSITE:PS50853"
FT REGION 522..545
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1090..1170
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1204..1277
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1346..1385
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 1430..1630
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1102..1147
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1226..1246
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1251..1265
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1347..1385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1430..1451
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1481..1495
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1512..1568
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 1581..1603
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1665 AA; 181909 MW; 7CDA89DC4F6D127F CRC64;
MTRDSTRVLT PLALLLALLW LIYVNRHFCH FFSGSRLRQE DTPPRIVEHP SDLIVSKGEP
ATLNCKAEGR PTPTVEWYKD GERVETDRDN PRSQRMLLPS GSLFFLRIVH GRRSKPDEGS
YVCVARNYLG EAVSHNASLE VAILRDDFRQ NPADVIVAAG EPAVLECQPP RGHPEPTISW
KKDGVNIDDR DERITIRGGK LMITNARKSD AGKYVCVGTN MVGERESEIA ELTVLERPSF
VRRPSSQVVL VDQSVEFRCE ARGDPVPTVR WRKDDGDLPK GRYEIREDHT LKIRRLVSAD
VGSYTCVAEN MVGKAEASAT LTVHVPPAFV VRPKNQVVGV GRTVTFQCEA TGNPQPAIFW
QREGSQNLLF SYQPPQPSSR FSVSQTGDLT ITDAVRSDGG YYSCQALNIA GSVITKALLE
VTDVVSDRPP PVIRQGPTNQ TVAVDGTVVL NCVTSGNPTP TILWRKDGVL VSTHDSRVKQ
LDTGALQIRY AKLSDTGTYT CTASTPSGEA SWKAYLEVQE SGAPFQPNRP TDPNLIPSAP
SKPEVTDVTR SSVTLSWKPN LNAGATPTSY IIEAFSHASG SSWQTLAEHV KTESFVLKGL
KPSAVYLFLV RAANAYGLSD PSPITDAVKT QDIPPTSQGV DHRQIQRELG DAVIHLHNPT
ILSSSSVRVQ WTVEQQSQYI QGYKVMYRPS PEGQQRSEWA VFEVRTPGEG SAVVPHLRKG
VTYEFKVRPF FNEFQGTDSD VKIGKTLEEA PSAPPRKVTV TESGDNGTAI IVSWQPPPEE
EQNGVVQEYK IWCLGNETRY HINRTVDGST FSVLIPSLAP GIRYSVEVAA STGAGPGVKS
DVTFFQLDAS GRMTDTVNQE NPLSQQISDV VKQPAFIAGI GAACWIILMV FSIWLYRHRK
KRNGLSSSYA GIRKVAYQRG GEGVSSAGRP GLLNIGDSAT QPWLADTWPN SCSNHNDCSI
NCCTAGNGNS DSNLATYSRP ADCIANYNNQ MENKQTNLMV PESGVYGDVD LSNKINEMKT
FNSPNLKDGR FVGPGGQPTP YATTQLIQSS IMGNNMNSDR GTGGSGGGLQ KQEISSQLQY
NIMEQNKLNK DRYRGGDSPM PATIPYSQTH DSHTGGSYNS SDRGSSSTSG SQGQKKGVRT
PKVPKQSTMN WADLLPPPPA NPPPSRNTEE YSLPMEERWD MSKWTSDLTC PMPPSHMYLQ
PDELEEEEEM ERGPTPPIRG AASSPAAVSY SHQSTATLTP SPQEEMQPML QDAPDSHERR
RHAVSPPPPP RPMSPSHTYG YINTPLALDT DGMEEEDILE EEEDGDETDA EVAKMHYHHT
HPHTNPHHPQ MHPRRLLLRG LEQTPASSMG DLESSVTGSM INGWGSASEE DNVSSGRSSA
VSSSDGSFFT DADFAQAVAA AAAAEYSGLR VAKYPSSQGQ DVGGASARKY QINPSSHRPG
SPVSTDSNMS MAAVHRRPPK KQKQHPVGHP ANQRREVFNE DLPPPPIPPP AVLKSPTHPS
KVALEGRGVI SPKAGEVRDK RGGTGGYRAR EDSDPRTSSS ERKDAQDRQK TAHGGKGNKH
ESSTTNKARQ HAEDIMPYSR PQFPTVNSPR DPSSSSSMSS RGSGGRRRGE GGRRNPADMG
LNTSGAFQPG DEEIEVKGSL KFYFSEIYMM AIYTVVKTMS HVCIC
//