ID I3KJH3_ORENI Unreviewed; 908 AA.
AC I3KJH3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 75.
DE SubName: Full=Metabotropic glutamate receptor 8 {ECO:0000313|Ensembl:ENSONIP00000021268.2};
GN Name=GRM8 {ECO:0000313|Ensembl:ENSONIP00000021268.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021268.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021268.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the G-protein coupled receptor 3 family.
CC {ECO:0000256|ARBA:ARBA00007242}.
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DR AlphaFoldDB; I3KJH3; -.
DR STRING; 8128.ENSONIP00000081370; -.
DR Ensembl; ENSONIT00000021287.2; ENSONIP00000021268.2; ENSONIG00000016874.2.
DR eggNOG; KOG1056; Eukaryota.
DR GeneTree; ENSGT01030000234648; -.
DR HOGENOM; CLU_005389_0_0_1; -.
DR TreeFam; TF313240; -.
DR Proteomes; UP000005207; Linkage group LG17.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0004930; F:G protein-coupled receptor activity; IEA:UniProtKB-KW.
DR CDD; cd06376; PBP1_mGluR_groupIII; 1.
DR Gene3D; 3.40.50.2300; -; 2.
DR Gene3D; 2.10.50.30; GPCR, family 3, nine cysteines domain; 1.
DR InterPro; IPR001828; ANF_lig-bd_rcpt.
DR InterPro; IPR000337; GPCR_3.
DR InterPro; IPR011500; GPCR_3_9-Cys_dom.
DR InterPro; IPR038550; GPCR_3_9-Cys_sf.
DR InterPro; IPR017978; GPCR_3_C.
DR InterPro; IPR017979; GPCR_3_CS.
DR InterPro; IPR001786; GPCR_3_mGluR4.
DR InterPro; IPR000162; GPCR_3_mtglu_rcpt.
DR InterPro; IPR028082; Peripla_BP_I.
DR PANTHER; PTHR24060; METABOTROPIC GLUTAMATE RECEPTOR; 1.
DR PANTHER; PTHR24060:SF26; METABOTROPIC GLUTAMATE RECEPTOR 8; 1.
DR Pfam; PF00003; 7tm_3; 1.
DR Pfam; PF01094; ANF_receptor; 1.
DR Pfam; PF07562; NCD3G; 1.
DR PRINTS; PR00248; GPCRMGR.
DR PRINTS; PR01054; MTABOTROPC4R.
DR PRINTS; PR00593; MTABOTROPICR.
DR SUPFAM; SSF53822; Periplasmic binding protein-like I; 1.
DR PROSITE; PS00979; G_PROTEIN_RECEP_F3_1; 1.
DR PROSITE; PS00981; G_PROTEIN_RECEP_F3_3; 1.
DR PROSITE; PS50259; G_PROTEIN_RECEP_F3_4; 1.
PE 3: Inferred from homology;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW G-protein coupled receptor {ECO:0000256|ARBA:ARBA00023040};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Receptor {ECO:0000256|ARBA:ARBA00023170};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Transducer {ECO:0000256|ARBA:ARBA00023224};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 12..32
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 596..616
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 636..656
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 662..681
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 702..729
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 760..781
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 793..815
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 835..857
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 596..870
FT /note="G-protein coupled receptors family 3 profile"
FT /evidence="ECO:0000259|PROSITE:PS50259"
SQ SEQUENCE 908 AA; 101380 MW; A5AACB921C9A5083 CRC64;
MEPQWRPVSY PLSPSFIFLL VATSYTWLIP VASPQRIPTD PQAAPEYAHS IRLDGDIILG
GLFPVHARGD RGTPCGELKK EKGIHRLEAM MFAIDLINKD PELLPNITLG ARILDTCSRD
TYALEQSLTF VQALIERDGS DVRCANGDPP IFTKPDKIVG VIGAAASSVS IMVANILRLF
KIPQISYAST APELSDNTRY DFFSRVVPPD SYQAQAMMDI VTAMEWNYVS TLASEGNYGE
SGVEAFIQIS RETGGVCIAQ SLKIPREPRP GEFDKIIRRL LETSNARAII MFANEDDIRR
VLDAAKRNNQ TGHFLWVGSD SWGSKISPVI GQERVAEGAI TILPKRASVD AFDRYFRSRS
LSNNRRNVWF AEFWEENFNC KLGMHGKRPG SLKKCTGLEK VGRDSSYEQE GKVQFVMDAV
YAMAHALHRM HRELCYGYPG LCPRMANNID GKELLNHIRA VNFNGSAGTP VVFNENGDAP
GRYDIFQYQI TNRSTAEYRV IGSWTNKLHL KVEAMRWRMG DPSFPASVCS LPCRTGERKK
VVKGVPCCWH CERCEGYHFQ ASEFTCELCP YEKRPDANRT GCTPIPIIKL EWHSPWAIVP
VFIAMLGIIA TSFVIVTFVR YNDTPIVRAS GREMSYVLLT GIFLCYAITF LMIATPDVGV
CSLRRIFLGL GMCFSYAALL TKTNRIHRIF EQGKKSVTAP RFISPASQLV ITFSLISVQL
LGVFVWFAVD PPHTVVDYGE QRTQDPMAAR GVLKCDISDL SLICSLGYSI LLMVTCTVYA
IKTRGVPETF NEAKPIGFTM YTTCIIWLAF IPIFFGTSQS AERMYIQTTT LTISLSLSAS
VSLGMLYMPK VYIILFHPEQ NVPKRKRSFK AIVTAATMSG KLTQKGGDRP NGEVKTELCE
SMETNTCG
//
