ID I3KJN9_ORENI Unreviewed; 376 AA.
AC I3KJN9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Arf-GAP with dual PH domain-containing protein 1 {ECO:0000313|Ensembl:ENSONIP00000021334.1};
GN Name=ADAP1 {ECO:0000313|Ensembl:ENSONIP00000021334.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000021334.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000021334.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_003456611.1; XM_003456563.4.
DR AlphaFoldDB; I3KJN9; -.
DR STRING; 8128.ENSONIP00000036857; -.
DR Ensembl; ENSONIT00000021353.2; ENSONIP00000021334.1; ENSONIG00000016920.2.
DR GeneID; 100707756; -.
DR KEGG; onl:100707756; -.
DR eggNOG; KOG0703; Eukaryota.
DR GeneTree; ENSGT00940000155698; -.
DR HOGENOM; CLU_061583_0_0_1; -.
DR OrthoDB; 1022106at2759; -.
DR TreeFam; TF324540; -.
DR Proteomes; UP000005207; Linkage group LG6.
DR GO; GO:0005096; F:GTPase activator activity; IEA:InterPro.
DR GO; GO:1902936; F:phosphatidylinositol bisphosphate binding; IEA:InterPro.
DR CDD; cd08832; ArfGap_ADAP; 1.
DR CDD; cd13252; PH1_ADAP; 1.
DR CDD; cd01251; PH2_ADAP; 1.
DR Gene3D; 1.10.220.150; Arf GTPase activating protein; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR037278; ARFGAP/RecO.
DR InterPro; IPR001164; ArfGAP_dom.
DR InterPro; IPR038508; ArfGAP_dom_sf.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR037849; PH1_ADAP.
DR InterPro; IPR037851; PH2_ADAP.
DR InterPro; IPR001849; PH_domain.
DR PANTHER; PTHR46021; ARF-GAP WITH DUAL PH DOMAIN-CONTAINING PROTEIN 1-LIKE PROTEIN; 1.
DR PANTHER; PTHR46021:SF3; ZGC:92360; 1.
DR Pfam; PF01412; ArfGap; 1.
DR Pfam; PF00169; PH; 1.
DR PRINTS; PR00405; REVINTRACTNG.
DR SMART; SM00105; ArfGap; 1.
DR SMART; SM00233; PH; 2.
DR SUPFAM; SSF57863; ArfGap/RecO-like zinc finger; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR PROSITE; PS50115; ARFGAP; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
PE 4: Predicted;
KW Metal-binding {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Zinc {ECO:0000256|PROSITE-ProRule:PRU00288};
KW Zinc-finger {ECO:0000256|PROSITE-ProRule:PRU00288}.
FT DOMAIN 5..134
FT /note="Arf-GAP"
FT /evidence="ECO:0000259|PROSITE:PS50115"
FT DOMAIN 130..231
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 253..358
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
SQ SEQUENCE 376 AA; 43525 MW; FEB9F45F384C8A41 CRC64;
MSANERSTRA FREILQKPGN DACADCGAPD PNWGSCTLGV FICLACSGIH RNIPDISKVK
SLTLSRWEDH ELEFMAQNGN ELMKSKYEAA VPVYYYKPTH KDCQVLREQW IRAKYERREF
SEPGKFTYEE GIRDGMLMKR GRDNGQFLSR RFVLSEREGT LKYFTKYDAK EPKAVIKVDS
INATFQPEKI GNPNGLQITY LKDYSTRNMF VYHDNGKEIV DWFNSIRAVQ LHYLKVAFPG
ATDAELVPRL TRNFVKEGYM EKTGPRQTEG FKKRWFTLDH RRLMYFKDPL DAFAKGEVFL
GNKNYGYSAS SGLPAGTHCN GAFEYGITIQ TPDRCFLFTC ETESDQQDWL KRFNDIMSAQ
MSPQEYTMEA TFRHKH
//
