ID I3KNA9_ORENI Unreviewed; 738 AA.
AC I3KNA9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 69.
DE RecName: Full=Ski oncogene {ECO:0000256|ARBA:ARBA00022369};
DE AltName: Full=Proto-oncogene c-Ski {ECO:0000256|ARBA:ARBA00032146};
GN Name=ski {ECO:0000313|Ensembl:ENSONIP00000022604.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000022604.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000022604.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the SKI family. {ECO:0000256|ARBA:ARBA00009513}.
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DR AlphaFoldDB; I3KNA9; -.
DR STRING; 8128.ENSONIP00000039122; -.
DR Ensembl; ENSONIT00000022624.2; ENSONIP00000022604.2; ENSONIG00000017935.2.
DR eggNOG; ENOG502QTF6; Eukaryota.
DR GeneTree; ENSGT00940000160546; -.
DR HOGENOM; CLU_025786_0_0_1; -.
DR TreeFam; TF324133; -.
DR Proteomes; UP000005207; Linkage group LG20.
DR GO; GO:0046332; F:SMAD binding; IEA:InterPro.
DR CDD; cd21083; DHD_Ski; 1.
DR CDD; cd00890; Prefoldin; 1.
DR Gene3D; 3.10.390.10; SAND domain-like; 1.
DR Gene3D; 3.10.260.20; Ski; 1.
DR InterPro; IPR014890; c-SKI_SMAD4-bd_dom.
DR InterPro; IPR047315; DHD_Ski.
DR InterPro; IPR009061; DNA-bd_dom_put_sf.
DR InterPro; IPR010919; SAND-like_dom_sf.
DR InterPro; IPR003380; SKI/SNO/DAC.
DR InterPro; IPR037000; Ski_DNA-bd_sf.
DR InterPro; IPR023216; Tscrpt_reg_SKI_SnoN.
DR PANTHER; PTHR10005:SF15; SKI ONCOGENE; 1.
DR PANTHER; PTHR10005; SKI ONCOGENE-RELATED; 1.
DR Pfam; PF08782; c-SKI_SMAD_bind; 1.
DR Pfam; PF02437; Ski_Sno; 1.
DR SMART; SM01046; c-SKI_SMAD_bind; 1.
DR SUPFAM; SSF46955; Putative DNA-binding domain; 1.
DR SUPFAM; SSF63763; SAND domain-like; 1.
PE 3: Inferred from homology;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207}.
FT DOMAIN 195..290
FT /note="c-SKI SMAD4-binding"
FT /evidence="ECO:0000259|SMART:SM01046"
FT REGION 321..395
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 432..584
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COILED 597..738
FT /evidence="ECO:0000256|SAM:Coils"
FT COMPBIAS 331..355
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 356..377
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 452..467
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 485..503
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 504..568
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 738 AA; 82659 MW; 217BA598B9F08AB9 CRC64;
METVSRPSFQ PHPGLQQTLK QFHLSSMSSL GGPAAFSARW QHELLFKKDG KEPEPVLQHL
PPPVMPGPLF IPSDRSTERC ETVLEGETIS CFVVGGEKRL CLPQILNTVL RDFTLQQINS
VCDELHIYCS RCTADQLEIL KVMGILPFSA PSCGLITKTD AERLCNALIY GGAYPPRCKK
EMNGGSLELQ FTDRSFKVYH ECFGKCKGLF VPELYTSPNA ACIQCMDCRL MYPTHKFVVH
GHKAQENRTC HWGFDSANWR AYILLGQDYT EKEEKARLEL FLDEIKEKFD FANKYKRKAS
SKLAMRKNPN QIRCVLRQEH AQTTSVSDPI PGKKSKHEDL SSQTPLADRE KQHDWLQSLS
TPNKGLNCIQ SRQRPSAFRP WSPHISASDK EPSSNPLALL RDGFYNYKSL ENAVAPNVAL
TPLPLGKVGP LSPSIPTTSY PSGSEPPGEG AHPNTRPRKR RATEELQSPA HEIPGPASSA
ASKPPLPRDD KDSEVEIEVE SRDEAASSMS SLSSPSFTSS SSSAKDLSSP GVQGPICTIM
SAESTAPAAT SVSAPAPVTS SESGLESELE SLRQALDSGL DSKESKEKFL HEIVKMRVKQ
EEKLGSALQA KRSLQQELEF LRVAKKEKLR EATEAKRNLR KEIERLRAES EKKMKEANES
RIRLKRELEQ ARQLRVCDKG CEAGRLRAKY SAQIEDLQMK LQHAEADREQ LRADLLHERE
AREHLERMVK ELQQQIKQ
//
