ID I3KPJ5_ORENI Unreviewed; 1068 AA.
AC I3KPJ5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 66.
DE SubName: Full=Pleckstrin homology and RUN domain containing M1 {ECO:0000313|Ensembl:ENSONIP00000023040.2};
GN Name=plekhm1 {ECO:0000313|Ensembl:ENSONIP00000023040.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000023040.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Ensembl:ENSONIP00000023040.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR RefSeq; XP_005453848.1; XM_005453791.3.
DR RefSeq; XP_019217827.1; XM_019362282.1.
DR AlphaFoldDB; I3KPJ5; -.
DR STRING; 8128.ENSONIP00000023040; -.
DR Ensembl; ENSONIT00000023060.2; ENSONIP00000023040.2; ENSONIG00000018298.2.
DR GeneID; 100704351; -.
DR KEGG; onl:100704351; -.
DR CTD; 9842; -.
DR eggNOG; KOG1829; Eukaryota.
DR GeneTree; ENSGT00940000155111; -.
DR HOGENOM; CLU_011318_0_0_1; -.
DR InParanoid; I3KPJ5; -.
DR OMA; HVLNCDL; -.
DR OrthoDB; 126314at2759; -.
DR TreeFam; TF317067; -.
DR Proteomes; UP000005207; Unplaced.
DR GO; GO:0005768; C:endosome; IEA:UniProtKB-KW.
DR GO; GO:0005764; C:lysosome; IEA:UniProtKB-KW.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0006914; P:autophagy; IEA:UniProtKB-KW.
DR CDD; cd00821; PH; 1.
DR CDD; cd17679; RUN_PLEKHM1; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 2.30.29.30; Pleckstrin-homology domain (PH domain)/Phosphotyrosine-binding domain (PTB); 2.
DR InterPro; IPR011993; PH-like_dom_sf.
DR InterPro; IPR001849; PH_domain.
DR InterPro; IPR025258; RH_dom.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047326; RUN_PLEKHM1.
DR PANTHER; PTHR12326; PLECKSTRIN HOMOLOGY DOMAIN CONTAINING PROTEIN; 1.
DR PANTHER; PTHR12326:SF5; PLECKSTRIN HOMOLOGY DOMAIN-CONTAINING FAMILY M MEMBER 1; 1.
DR Pfam; PF13901; RH_dom; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM01175; DUF4206; 1.
DR SMART; SM00233; PH; 2.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF50729; PH domain-like; 2.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50003; PH_DOMAIN; 2.
DR PROSITE; PS50826; RUN; 1.
PE 4: Predicted;
KW Autophagy {ECO:0000256|ARBA:ARBA00023006};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Lysosome {ECO:0000256|ARBA:ARBA00023228};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Repeat {ECO:0000256|ARBA:ARBA00022737};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771}.
FT DOMAIN 41..182
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 530..621
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT DOMAIN 692..789
FT /note="PH"
FT /evidence="ECO:0000259|PROSITE:PS50003"
FT REGION 267..302
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 325..401
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 417..472
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 489..515
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 645..683
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 267..298
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 336..385
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 445..472
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 659..683
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 1068 AA; 119389 MW; 60F46CBD36CA876F CRC64;
MLATQTEAPH EAKDVKKIKE KLAQSLKALQ KRYVASDSVV TSDDSDANLL CCALEAIFIH
GIKSKYIRSE SRSSSRKGDR GPLPQPFFWS LLKSVTHRDV VTELEKISFV GTDVGRCRAW
LRLALNHGLL ECYLVSLFRE DSKLKAHYQP SALLLNPEER EVLLSYLQGL ASLTFSLSYK
SSVLNEWTTT PLALAGLCPL SQADLLDLPL NGGDPPTSKP ICKEIWDTVS QSSGSSDALD
VQRGCPVLVG RGSDLLQGSQ TALRSSNLSL DTTGSSQLSS SLSSDSLLQG QDPRSPTGEH
WSSCDLEAAI NPNICTKRPQ KDSLTDFRES GHCSQDSTQE DSFVSSMGPS QFSEKGIISD
SEPQASEYQP PNFGQLDLEQ PETTTELPSS DDDKCPPEVC KSASSELHSD IGLVSAVSEP
AEPVEEVSVT VEPVQEEKLT ESSEKTNADS VVHQCPRRST SILSRKSSSD SLSHSYSWIS
DDDIYKPHLE NLPDSDDAPV SPPAAEPSIS PSRPSVVHRR QIGLFNPFRG LLKLGHLERR
SAVGLWRDYY CELSPFEFRL YVNAEERICC ENCSLVRCED VRITSSEGRF ELIFPGKRLN
LRAANRDEAE DWVDRIIEAV NKSRPVPHDE QWEVLHTGCE NGVEERAVSS PPLAPSSPEQ
GPSGSDACGG QDSPSPPQQD FDWTSTADLE TDSIKEAVLY FSTDPEARTW ERMVFSLSLE
TLKGFLVKEG RKLQRLNYPV EEIRDVVPDV SQGGPAFFKL LTIRETLRFR AENEKEARFW
RKFIRDALDS YLENGECEGS EVPLEATGNL YRLVQHRLKE DGALLVHLFK VPSEKGLDTQ
SFKCAGCPQK IGLSLGRARL CEFSGKYYCE SCHKGNTSII PSRMVHNWDV TQREVSKKAL
WLLKQVEQEP LLNLEQLNPE LVAHAESMGQ AHEQRQKLCL LGEYLRTCRS GACKKLQARM
GQRTYLLESN HLYSVKDLRQ VAEGQYVNFL RTLVQHASNH VFSCDLCTQR GYICQICHSS
DTIFPFQFET TTRCEDCKAL FHISCKADGQ SCPRCQRMRK YMERDLRD
//
