ID   I3KSS9_ORENI            Unreviewed;       773 AA.
AC   I3KSS9;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 61.
DE   SubName: Full=Melanocyte protein PMEL {ECO:0000313|Ensembl:ENSONIP00000024175.1};
GN   Name=LOC100711455 {ECO:0000313|Ensembl:ENSONIP00000024175.1};
OS   Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC   Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC   Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX   NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000024175.1, ECO:0000313|Proteomes:UP000005207};
RN   [1] {ECO:0000313|Proteomes:UP000005207}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   Broad Institute Genome Assembly Team;
RG   Broad Institute Sequencing Platform;
RA   Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT   "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL   Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSONIP00000024175.1}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the PMEL/NMB family.
CC       {ECO:0000256|ARBA:ARBA00025776}.
CC   ---------------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC   ---------------------------------------------------------------------------
DR   RefSeq; XP_005469484.1; XM_005469427.3.
DR   RefSeq; XP_019214527.1; XM_019358982.1.
DR   RefSeq; XP_019214528.1; XM_019358983.1.
DR   AlphaFoldDB; I3KSS9; -.
DR   STRING; 8128.ENSONIP00000024175; -.
DR   Ensembl; ENSONIT00000024196.2; ENSONIP00000024175.1; ENSONIG00000019206.2.
DR   GeneID; 100711455; -.
DR   KEGG; onl:100711455; -.
DR   CTD; 321239; -.
DR   eggNOG; ENOG502QV5K; Eukaryota.
DR   GeneTree; ENSGT00950000183188; -.
DR   HOGENOM; CLU_017264_0_0_1; -.
DR   InParanoid; I3KSS9; -.
DR   OMA; RDQDWLG; -.
DR   OrthoDB; 5354575at2759; -.
DR   TreeFam; TF334865; -.
DR   Proteomes; UP000005207; Linkage group LG5.
DR   GO; GO:0016020; C:membrane; IEA:UniProtKB-KW.
DR   CDD; cd00146; PKD; 1.
DR   Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR   InterPro; IPR013783; Ig-like_fold.
DR   InterPro; IPR045219; PKAT.
DR   InterPro; IPR046846; PKAT_KLD.
DR   InterPro; IPR022409; PKD/Chitinase_dom.
DR   InterPro; IPR000601; PKD_dom.
DR   InterPro; IPR035986; PKD_dom_sf.
DR   PANTHER; PTHR11861:SF1; MELANOCYTE PROTEIN PMEL; 1.
DR   PANTHER; PTHR11861; MELANOCYTE PROTEIN PMEL 17-RELATED; 1.
DR   Pfam; PF20433; PKAT_KLD; 1.
DR   Pfam; PF00801; PKD; 1.
DR   SMART; SM00089; PKD; 1.
DR   SUPFAM; SSF49299; PKD domain; 1.
DR   PROSITE; PS50093; PKD; 1.
PE   3: Inferred from homology;
KW   Membrane {ECO:0000256|SAM:Phobius};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW   Signal {ECO:0000256|ARBA:ARBA00022729, ECO:0000256|SAM:SignalP};
KW   Transmembrane {ECO:0000256|SAM:Phobius};
KW   Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT   SIGNAL          1..17
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT   CHAIN           18..773
FT                   /evidence="ECO:0000256|SAM:SignalP"
FT                   /id="PRO_5003674915"
FT   TRANSMEM        700..723
FT                   /note="Helical"
FT                   /evidence="ECO:0000256|SAM:Phobius"
FT   DOMAIN          243..274
FT                   /note="PKD"
FT                   /evidence="ECO:0000259|PROSITE:PS50093"
SQ   SEQUENCE   773 AA;  81041 MW;  C8BC277885E02771 CRC64;
     MKTLVLLVLA FATTISATRQ RSHFTRYRSW NSRMYPVWND GDPRFRNCWL GGNVTFDLKN
     DAPTLTGAKA GFTINLNFPP NQTVLPGGEV VWANNCTVDG KQYQEGQAVY PDQDTDWTGV
     FPNGTPFIRS QNRKPHYVFV WKTWGRYWQV ADGPSSSLTI GTDNIPLGSY NMEVVIYHCR
     GRNRFIPLGY ASTVFTITDQ VPFTISLAQI NDVNQNDQNF IQNQAIGFTV NIHDPSQYLN
     NAEISFTWDF GDNRGTLISR EHTVTHTYIT AGTFKPQVVL MASIPNNCGN PTAAAPVDPS
     AAPAVVVMAS TQEAVPAVPV EGGDTIAVDV VASDATPVAA SVQPADANTD DGEAAADADT
     EVVVVASVAP AAIDTAVVAA NTAAPATEVE QEAADAEVVP AATVAPGAEE PADADTAAAD
     DTAEVTVATE DVAVIDAAAA AASVAPVAEG EEVEVVDTIT VAPITDGATE EEAADGVEAV
     EATAAAEVAL AETQAPADNV VAPAATEPTA VEEAVVNAEV EAVETENEVA ATAAAAVEDE
     AAPAEGEVQI EMEADPAQVA LVVAKRQAPE LTADCMVYRY GSLATSVDVV QGIESVEIVQ
     VANVVSLETA LDQNAVDVTI SCQGSLPSEV CTVISDADCI TPVQTICNAA SPSPDCQMIL
     RQFFNDSGVF CLNVSLTNDV SLAMASARVS VSVASGGSPA GTAATVLGVM VLACVVCCIG
     LMYRRFKQYQ PLREDRANNG GISAVTSVPL LLWNLLSRQS PGESRPLLQG RIV
//