ID I3KX14_ORENI Unreviewed; 654 AA.
AC I3KX14;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 17-JUN-2020, sequence version 2.
DT 27-MAR-2024, entry version 68.
DE RecName: Full=Interferon-induced GTP-binding protein Mx {ECO:0000256|ARBA:ARBA00015210};
DE AltName: Full=Interferon-inducible Mx protein {ECO:0000256|ARBA:ARBA00031810};
GN Name=LOC100709769 {ECO:0000313|Ensembl:ENSONIP00000025660.2};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025660.2, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025660.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cytoplasm {ECO:0000256|ARBA:ARBA00004496}.
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DR RefSeq; XP_019214275.1; XM_019358730.1.
DR AlphaFoldDB; I3KX14; -.
DR Ensembl; ENSONIT00000025681.2; ENSONIP00000025660.2; ENSONIG00000020362.2.
DR GeneID; 112841624; -.
DR eggNOG; KOG0446; Eukaryota.
DR GeneTree; ENSGT00940000164201; -.
DR HOGENOM; CLU_008964_8_0_1; -.
DR OrthoDB; 3796094at2759; -.
DR TreeFam; TF331484; -.
DR Proteomes; UP000005207; Linkage group LG5.
DR GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR GO; GO:0005525; F:GTP binding; IEA:UniProtKB-KW.
DR GO; GO:0003924; F:GTPase activity; IEA:InterPro.
DR CDD; cd08771; DLP_1; 1.
DR Gene3D; 1.20.120.1240; Dynamin, middle domain; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR022812; Dynamin.
DR InterPro; IPR001401; Dynamin_GTPase.
DR InterPro; IPR045063; Dynamin_N.
DR InterPro; IPR000375; Dynamin_stalk.
DR InterPro; IPR030381; G_DYNAMIN_dom.
DR InterPro; IPR003130; GED.
DR InterPro; IPR020850; GED_dom.
DR InterPro; IPR027417; P-loop_NTPase.
DR PANTHER; PTHR11566; DYNAMIN; 1.
DR PANTHER; PTHR11566:SF225; INTERFERON-INDUCED GTP-BINDING PROTEIN MXA-RELATED; 1.
DR Pfam; PF01031; Dynamin_M; 1.
DR Pfam; PF00350; Dynamin_N; 1.
DR Pfam; PF02212; GED; 1.
DR PRINTS; PR00195; DYNAMIN.
DR SMART; SM00053; DYNc; 1.
DR SMART; SM00302; GED; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51718; G_DYNAMIN_2; 1.
DR PROSITE; PS51388; GED; 1.
PE 4: Predicted;
KW Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW GTP-binding {ECO:0000256|ARBA:ARBA00023134};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..19
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 20..654
FT /note="Interferon-induced GTP-binding protein Mx"
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5025496619"
FT DOMAIN 50..323
FT /note="Dynamin-type G"
FT /evidence="ECO:0000259|PROSITE:PS51718"
FT DOMAIN 546..637
FT /note="GED"
FT /evidence="ECO:0000259|PROSITE:PS51388"
SQ SEQUENCE 654 AA; 74449 MW; C8D2BA5BD4383842 CRC64;
MLSLCPFLIF IFVVRQAETT MSTLNQQYDE KVRPLIDLID SLRSLGVEKD LALPAIAVIG
DQSSGKSSVL EALSGVALPR GGGIVTRCPL ELKMTRKKEG EAWYGKISYR DFEEKIKEPE
LVEKMIREAQ LKLVGNEVGI SSELISLEIA SPDVPDLTLI DLPGIARVAV DGQSADIGDK
IKTMIQTVIS KQETINLVVV PCNVDIATTE ALNMAKLVDP DGERTLGVLT KPDLVDKGTE
ENVVKIVHNE VIPLKKGYMV VKCRGQKEIT GKVSLSEALK NEEAFFKEHA HFQTLFDEGQ
ATVPNLAEKL TLELVHHIQK SLPRLDEQTQ KKLEQTRANL NKLRTGPPSD ATKRQKFLSD
LVLAFTQDAI RLTTGEELKC GYNSSIFFTL RNEFEAWEKI IKDSGSSFKV HSLREESQFE
RMYRGRELPL FVSYSSFESI IQKQIKQLEE PAIQKLKEVS EVVRKELFEL AQNSFVGFPN
LINTAKMNIE TIMKEREEEA KYILGMQFKM EMVVYTQDRK YITEIRNKIA QEGQAKGQLY
TSGMTSKEMM KHFEVYYKIA GQRLADQIPL VIRYQMLQEF ASELQSKMLD TFTNKERKEY
LLEEDGGTKN KREDLKMRLE RLSRAHILLS EFSRNTTLTE VKNFNSMENF LPNF
//
