ID I3KXS2_ORENI Unreviewed; 563 AA.
AC I3KXS2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 73.
DE SubName: Full=Suppressor of cytokine signaling 5 {ECO:0000313|Ensembl:ENSONIP00000025918.1};
GN Name=socs5 {ECO:0000313|Ensembl:ENSONIP00000025918.1};
OS Oreochromis niloticus (Nile tilapia) (Tilapia nilotica).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC Actinopterygii; Neopterygii; Teleostei; Neoteleostei; Acanthomorphata;
OC Ovalentaria; Cichlomorphae; Cichliformes; Cichlidae; African cichlids;
OC Pseudocrenilabrinae; Oreochromini; Oreochromis.
OX NCBI_TaxID=8128 {ECO:0000313|Ensembl:ENSONIP00000025918.1, ECO:0000313|Proteomes:UP000005207};
RN [1] {ECO:0000313|Proteomes:UP000005207}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG Broad Institute Genome Assembly Team;
RG Broad Institute Sequencing Platform;
RA Di Palma F., Johnson J., Lander E.S., Lindblad-Toh K.;
RT "The Genome Sequence of Oreochromis niloticus (Nile Tilapia).";
RL Submitted (JAN-2012) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSONIP00000025918.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- PATHWAY: Protein modification; protein ubiquitination.
CC {ECO:0000256|ARBA:ARBA00004906}.
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DR RefSeq; XP_013131235.1; XM_013275781.2.
DR AlphaFoldDB; I3KXS2; -.
DR STRING; 8128.ENSONIP00000025918; -.
DR Ensembl; ENSONIT00000025939.2; ENSONIP00000025918.1; ENSONIG00000020613.2.
DR GeneID; 100708455; -.
DR KEGG; onl:100708455; -.
DR CTD; 559639; -.
DR eggNOG; KOG4566; Eukaryota.
DR GeneTree; ENSGT00940000164285; -.
DR HOGENOM; CLU_035609_1_0_1; -.
DR InParanoid; I3KXS2; -.
DR OMA; CQNLFNH; -.
DR OrthoDB; 5362214at2759; -.
DR TreeFam; TF321368; -.
DR UniPathway; UPA00143; -.
DR Proteomes; UP000005207; Linkage group LG13.
DR GO; GO:0035556; P:intracellular signal transduction; IEA:InterPro.
DR GO; GO:0009968; P:negative regulation of signal transduction; IEA:UniProtKB-KW.
DR GO; GO:0016567; P:protein ubiquitination; IEA:UniProtKB-UniPathway.
DR Gene3D; 3.30.505.10; SH2 domain; 1.
DR InterPro; IPR000980; SH2.
DR InterPro; IPR036860; SH2_dom_sf.
DR InterPro; IPR022252; SOCS4/SOCS5_dom.
DR InterPro; IPR001496; SOCS_box.
DR InterPro; IPR036036; SOCS_box-like_dom_sf.
DR PANTHER; PTHR10155; PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT; 1.
DR PANTHER; PTHR10155:SF15; SUPPRESSOR OF CYTOKINE SIGNALING 5; 1.
DR Pfam; PF00017; SH2; 1.
DR Pfam; PF12610; SOCS; 1.
DR Pfam; PF07525; SOCS_box; 1.
DR SMART; SM00252; SH2; 1.
DR SMART; SM00253; SOCS; 1.
DR SMART; SM00969; SOCS_box; 1.
DR SUPFAM; SSF55550; SH2 domain; 1.
DR SUPFAM; SSF158235; SOCS box-like; 1.
DR PROSITE; PS50001; SH2; 1.
DR PROSITE; PS50225; SOCS; 1.
PE 4: Predicted;
KW Growth regulation {ECO:0000256|ARBA:ARBA00022604};
KW Reference proteome {ECO:0000313|Proteomes:UP000005207};
KW SH2 domain {ECO:0000256|PROSITE-ProRule:PRU00191};
KW Signal transduction inhibitor {ECO:0000256|ARBA:ARBA00022700};
KW Ubl conjugation pathway {ECO:0000256|ARBA:ARBA00022786}.
FT DOMAIN 407..502
FT /note="SH2"
FT /evidence="ECO:0000259|PROSITE:PS50001"
FT DOMAIN 497..546
FT /note="SOCS box"
FT /evidence="ECO:0000259|PROSITE:PS50225"
FT REGION 97..154
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 304..324
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 361..381
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 135..154
FT /note="Basic and acidic residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 563 AA; 62081 MW; CD9516944F63ADC3 CRC64;
MKKVGIMWSN LKSRCQTLFH NNSSGPHESR IEADTVHCVV DIGQGGSSGG AQASGASSPS
RSLLPVPVVT AGRRHHNCVS DIPQIVEITI DKDVEDVRGG SGGVPLARRD SYSRHAPWGG
KKKHSCSTKT QSSLEADRRS GRLRGSGNRR DRRYGVSSIQ ETNDSVSVGR SLNGRSLRQR
LSDTVGLCLP LPARRCSRSS KNTVTSKRKI HLTELMLETC PFPPGSDLAH KWHLIKQHTA
PVSPHSSTAL LDAFDPAHPS PEDEEERLRE RRRLSIEEGV DPPPNAQIHT LEASVPGSSL
YKLGPKMAPG MGEASGEGRV TGAGSSLAAA SSGACGQLLG AAASSQDCDS EEDSTTLCLQ
ARRPKQRHAS GDGHLSRQQP GPWKVHTQID YIHCLVPDLL EITALPCYWG VMDRYEAEAL
LDGRPEGTFL LRDSAQEDYL FSVSFRRYNR SLHARIEQWN HNFSFDAHDP CVFHSSTVTG
LLEHYKDPSA CMFFEPLLTA PLHRTFPFGL QHLARAAICR WTTYDGIGSL PLPPALQDFL
KEYHYKQKVR VRWLEREPPL KVK
//
