ID I3L5Q7_PIG Unreviewed; 496 AA.
AC I3L5Q7;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 69.
DE SubName: Full=Matrilin 1 {ECO:0000313|Ensembl:ENSSSCP00000019357.3};
GN Name=MATN1 {ECO:0000313|Ensembl:ENSSSCP00000019357.3,
GN ECO:0000313|VGNC:VGNC:90042};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000019357.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000019357.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000019357.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000019357.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR AlphaFoldDB; I3L5Q7; -.
DR SMR; I3L5Q7; -.
DR STRING; 9823.ENSSSCP00000019357; -.
DR PaxDb; 9823-ENSSSCP00000019357; -.
DR Ensembl; ENSSSCT00000030042.4; ENSSSCP00000019357.3; ENSSSCG00000022554.4.
DR VGNC; VGNC:90042; MATN1.
DR eggNOG; KOG1217; Eukaryota.
DR GeneTree; ENSGT00940000159638; -.
DR HOGENOM; CLU_008905_7_0_1; -.
DR InParanoid; I3L5Q7; -.
DR OrthoDB; 1453590at2759; -.
DR TreeFam; TF330078; -.
DR Reactome; R-SSC-3000178; ECM proteoglycans.
DR Proteomes; UP000008227; Chromosome 6.
DR Bgee; ENSSSCG00000022554; Expressed in forelimb bud and 4 other cell types or tissues.
DR GO; GO:0062023; C:collagen-containing extracellular matrix; IBA:GO_Central.
DR GO; GO:0005509; F:calcium ion binding; IEA:InterPro.
DR GO; GO:0003429; P:growth plate cartilage chondrocyte morphogenesis; IEA:Ensembl.
DR GO; GO:0030500; P:regulation of bone mineralization; IEA:Ensembl.
DR CDD; cd01475; vWA_Matrilin; 1.
DR Gene3D; 1.20.5.30; -; 1.
DR Gene3D; 2.10.25.10; Laminin; 1.
DR Gene3D; 3.40.50.410; von Willebrand factor, type A domain; 2.
DR InterPro; IPR001881; EGF-like_Ca-bd_dom.
DR InterPro; IPR000742; EGF-like_dom.
DR InterPro; IPR036337; Matrilin_cc_sf.
DR InterPro; IPR019466; Matrilin_coiled-coil_trimer.
DR InterPro; IPR002035; VWF_A.
DR InterPro; IPR036465; vWFA_dom_sf.
DR PANTHER; PTHR24020:SF16; CARTILAGE MATRIX PROTEIN; 1.
DR PANTHER; PTHR24020; COLLAGEN ALPHA; 1.
DR Pfam; PF14670; FXa_inhibition; 1.
DR Pfam; PF10393; Matrilin_ccoil; 1.
DR Pfam; PF00092; VWA; 2.
DR PRINTS; PR00453; VWFADOMAIN.
DR SMART; SM00181; EGF; 1.
DR SMART; SM00179; EGF_CA; 1.
DR SMART; SM01279; Matrilin_ccoil; 1.
DR SMART; SM00327; VWA; 2.
DR SUPFAM; SSF58002; Chicken cartilage matrix protein; 1.
DR SUPFAM; SSF53300; vWA-like; 2.
DR PROSITE; PS01186; EGF_2; 1.
DR PROSITE; PS50234; VWFA; 2.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|ARBA:ARBA00023054};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW EGF-like domain {ECO:0000256|ARBA:ARBA00022536};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Signal {ECO:0000256|SAM:SignalP}.
FT SIGNAL 1..25
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 26..496
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5023945232"
FT DOMAIN 41..216
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
FT DOMAIN 275..447
FT /note="VWFA"
FT /evidence="ECO:0000259|PROSITE:PS50234"
SQ SEQUENCE 496 AA; 53825 MW; FA829C54611FC3AD CRC64;
MRVTCGPSPV LCGLLLLLQA PHTLGLAPLS RGPLCRTRPT DLVFVVDSSR SVRPVEFEKV
KVFLSQVIES LDVGPNATRV GLVNYASSVK QEFPLRAHSS KAALLQAVRR IQPLSTGTMT
GLAIHFAITK ALSDAEGGRP RSPDISKVVI VVTDGRPQDS VRDVSARARA SGIELFAIGV
GRVDKATLQQ IASEPQDEHV DYVESYSVIE KLSKKFQEAF CLVSDLCATG DHDCEQVCLS
SPGSYTCACR EGFTLNSDGK TCNVCSGGGG SLATDLVFLI DGSKSVRPEN FELVKKFINQ
IVDTLDVSDK LAQVGLVQYS SSVRQEFPLG RFHTKKDIKA AVRNMSYMEK GTMTGAALKY
LIDNSFTVSS GARPGAQKVG VVFTDGRSQD YINDAAKKAK DLGFKMFAVG VGNAVEDELR
EIASEPVAEH YFYTADYKTI NQIGKKLQKK ICVEEDPCAC ESIVKFQSKV EGLLQALTRK
LEAVSKRLAI LENRIV
//
