ID   I3L7W7_PIG              Unreviewed;      1275 AA.
AC   I3L7W7;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 65.
DE   SubName: Full=Tetratricopeptide repeat domain 21A {ECO:0000313|Ensembl:ENSSSCP00000020125.2};
GN   Name=TTC21A {ECO:0000313|Ensembl:ENSSSCP00000020125.2,
GN   ECO:0000313|VGNC:VGNC:94538};
OS   Sus scrofa (Pig).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX   NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000020125.2, ECO:0000313|Proteomes:UP000008227};
RN   [1] {ECO:0000313|Ensembl:ENSSSCP00000020125.2, ECO:0000313|Proteomes:UP000008227}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000020125.2,
RC   ECO:0000313|Proteomes:UP000008227};
RG   Porcine genome sequencing project;
RL   Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSSCP00000020125.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SIMILARITY: Belongs to the TTC21 family.
CC       {ECO:0000256|ARBA:ARBA00010935}.
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DR   AlphaFoldDB; I3L7W7; -.
DR   IntAct; I3L7W7; 1.
DR   Ensembl; ENSSSCT00000022750.2; ENSSSCP00000020125.2; ENSSSCG00000011263.5.
DR   VGNC; VGNC:94538; TTC21A.
DR   GeneTree; ENSGT00390000005979; -.
DR   HOGENOM; CLU_006149_0_0_1; -.
DR   Proteomes; UP000008227; Chromosome 13.
DR   Bgee; ENSSSCG00000011263; Expressed in testis and 42 other cell types or tissues.
DR   ExpressionAtlas; I3L7W7; baseline and differential.
DR   GO; GO:0030317; P:flagellated sperm motility; IEA:Ensembl.
DR   GO; GO:0007286; P:spermatid development; IEA:Ensembl.
DR   Gene3D; 1.25.40.10; Tetratricopeptide repeat domain; 5.
DR   InterPro; IPR011990; TPR-like_helical_dom_sf.
DR   InterPro; IPR019734; TPR_repeat.
DR   InterPro; IPR040364; TTC21A/TTC21B.
DR   PANTHER; PTHR14699; STI2 PROTEIN-RELATED; 1.
DR   PANTHER; PTHR14699:SF2; TETRATRICOPEPTIDE REPEAT PROTEIN 21A; 1.
DR   Pfam; PF13432; TPR_16; 1.
DR   Pfam; PF14559; TPR_19; 1.
DR   Pfam; PF13181; TPR_8; 2.
DR   SMART; SM00028; TPR; 11.
DR   SUPFAM; SSF48452; TPR-like; 4.
DR   PROSITE; PS50005; TPR; 3.
PE   3: Inferred from homology;
KW   Coiled coil {ECO:0000256|SAM:Coils};
KW   Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW   Repeat {ECO:0000256|ARBA:ARBA00022737};
KW   TPR repeat {ECO:0000256|PROSITE-ProRule:PRU00339}.
FT   REPEAT          493..526
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          844..877
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   REPEAT          912..945
FT                   /note="TPR"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00339"
FT   COILED          368..395
FT                   /evidence="ECO:0000256|SAM:Coils"
SQ   SEQUENCE   1275 AA;  144833 MW;  1EAFE79D8B7236A3 CRC64;
     MSNNDSSLMA GIIYYCQERY FRHMQQAAAV GLEKFNNDPV LQFFKAYGVL MEERIQDAIS
     SLESIRNHPD VSLCSTMALI YAHKCCETID REAIQELESS LKEIRKTASG TALYHAGLFL
     WLIGCHDKAK EYTDRLLKVS SSSREGCMLR GWVDLSSDKP HTVKKSIKYL EQGMQDTKDV
     LGLMGKAKYF MMLQNYSGAL EVVNQITVTS GSFLPALVLK MQLFLARQDW EQTVETGHRI
     LEKDESNIDA CQILAVHELA REGNITTAAE HVRNLINALE TREPQNPSLH LKKILVVSRL
     CGRHQVILRL VCSFIERTFR ATSSYAHVAT ELGYLFILRD QVKEASLWYS EAMKLSKSGM
     AMTGITWCQI LEGHLEEAEH QLEFLKEVQQ SLGKSEVLVF LQALLASRKH KGEQEVTALL
     KEAAELHFSS MRALPLGSEY LERLDPLFLV CIAKEYLLFC PKQPRSPGQI VSPLLKQVTA
     ILNPVVKVAP ALIDPLYVMA QVKYLSGELE NAQSTLQRCL ELDPTSVDAH LLVSQIYLAQ
     GNFAMCSHCL ELGISHNFQV RDHPLYHFIK ARALNKSGDY PEAIKALKMI INVPTLKMEE
     NKKFRGPSVQ PSERVSILLE LVDALRMNGE LHEATKIMQD AINEFSGTPE EIRITIANVD
     LVLSKGNVDL ALSMLRNITP KQPYYMEAKE KMASIYLQTH KDMRLYIGCY RELCEHLPGP
     HTSLLLGDAF MNIQEAINYY EAAQKISGQD FLCCDLAELF LKLKKFSKAE KVLKQALDHD
     FVKDIPSMMN DVKCLLLLAK VYKSHKKEDV METLNKAMDL QSRILKRVPL EQPEMIPSQK
     QLAASICIHF GEYYLAEKEY AKAVRSYKDA LSYSPTDNKV VLELAHLYLL QGHLDLCEQH
     CDILLQTEKN HEMASVMMAD LMFRKQKYEA AINLYHQVLE KAPDNFPVLN KLIDLLRRSG
     KLEDAPAFFE LAKKMSSRVP LEPGFNYCRG IYCWHIGQPN EALKFLNKAR KDNTWGQSAT
     YCMVQICLNP DNEIVGGEAF ESLVPESNSL ERKESERHGV RTAEKLLREF YPQSASGQTQ
     LRLLQSLCLL ATREKANVEA ALGTFIDMAQ AEKDSVPALL AMAQAYSLLK QVPKARTQLK
     RLAKAPWALA EADDLEKSWL LLADIYCQGG KFDLASELLR RCVQYNKSCC KAYEYMGFIM
     EREQSYKDAA TNYELAWKYS HHANPAIGFK LAFNYLKDKR FVEAIEVCHS VLREHPNYPK
     IREEILKKAQ GSLRP
//