ID I3LBF0_PIG Unreviewed; 813 AA.
AC I3LBF0; A0A480YTS2; A0A481AWU0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 14-DEC-2022, sequence version 4.
DT 27-MAR-2024, entry version 70.
DE SubName: Full=Calpain-7 {ECO:0000313|EMBL:HDA68596.1, ECO:0000313|Ensembl:ENSSSCP00000021370.4};
GN Name=CAPN7 {ECO:0000313|Ensembl:ENSSSCP00000021370.4,
GN ECO:0000313|VGNC:VGNC:111186};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000021370.4, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000021370.4, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000021370.4,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA68596.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000021370.4}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the peptidase C2 family.
CC {ECO:0000256|ARBA:ARBA00007623}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01113120; HDA68596.1; -; Transcribed_RNA.
DR EMBL; DQIR01197861; HDB53338.1; -; Transcribed_RNA.
DR EMBL; DQIR01222093; HDB77570.1; -; Transcribed_RNA.
DR EMBL; DQIR01224893; HDB80370.1; -; Transcribed_RNA.
DR EMBL; DQIR01231306; HDB86783.1; -; Transcribed_RNA.
DR EMBL; DQIR01288392; HDC43870.1; -; Transcribed_RNA.
DR EMBL; DQIR01293704; HDC49182.1; -; Transcribed_RNA.
DR Ensembl; ENSSSCT00000022738.4; ENSSSCP00000021370.4; ENSSSCG00000030697.4.
DR VGNC; VGNC:111186; CAPN7.
DR GeneTree; ENSGT00940000155892; -.
DR HOGENOM; CLU_006770_2_0_1; -.
DR OMA; GDYRRGC; -.
DR TreeFam; TF322245; -.
DR Reactome; R-SSC-1474228; Degradation of the extracellular matrix.
DR Proteomes; UP000008227; Chromosome 13.
DR Bgee; ENSSSCG00000030697; Expressed in pituitary gland and 44 other cell types or tissues.
DR GO; GO:0005813; C:centrosome; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0004198; F:calcium-dependent cysteine-type endopeptidase activity; IEA:InterPro.
DR GO; GO:0004197; F:cysteine-type endopeptidase activity; IBA:GO_Central.
DR GO; GO:0090541; F:MIT domain binding; IEA:Ensembl.
DR GO; GO:0010634; P:positive regulation of epithelial cell migration; IEA:Ensembl.
DR GO; GO:0006508; P:proteolysis; IBA:GO_Central.
DR GO; GO:0097264; P:self proteolysis; IEA:Ensembl.
DR CDD; cd00044; CysPc; 1.
DR CDD; cd02681; MIT_calpain7_1; 1.
DR Gene3D; 2.60.120.380; -; 2.
DR Gene3D; 3.90.70.10; Cysteine proteinases; 1.
DR Gene3D; 1.20.58.80; Phosphotransferase system, lactose/cellobiose-type IIA subunit; 2.
DR InterPro; IPR022684; Calpain_cysteine_protease.
DR InterPro; IPR022682; Calpain_domain_III.
DR InterPro; IPR022683; Calpain_III.
DR InterPro; IPR036213; Calpain_III_sf.
DR InterPro; IPR007330; MIT_dom.
DR InterPro; IPR036181; MIT_dom_sf.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR001300; Peptidase_C2_calpain_cat.
DR PANTHER; PTHR46143; CALPAIN-7; 1.
DR PANTHER; PTHR46143:SF1; CALPAIN-7; 1.
DR Pfam; PF01067; Calpain_III; 1.
DR Pfam; PF04212; MIT; 2.
DR Pfam; PF00648; Peptidase_C2; 1.
DR PRINTS; PR00704; CALPAIN.
DR SMART; SM00720; calpain_III; 1.
DR SMART; SM00230; CysPc; 1.
DR SMART; SM00745; MIT; 2.
DR SUPFAM; SSF49758; Calpain large subunit, middle domain (domain III); 2.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF116846; MIT domain; 2.
DR PROSITE; PS50203; CALPAIN_CAT; 1.
PE 3: Inferred from homology;
KW Hydrolase {ECO:0000256|ARBA:ARBA00022801, ECO:0000256|PROSITE-
KW ProRule:PRU00239}; Protease {ECO:0000256|PROSITE-ProRule:PRU00239};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Thiol protease {ECO:0000256|PROSITE-ProRule:PRU00239}.
FT DOMAIN 260..540
FT /note="Calpain catalytic"
FT /evidence="ECO:0000259|PROSITE:PS50203"
FT ACT_SITE 290
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 458
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
FT ACT_SITE 478
FT /evidence="ECO:0000256|PIRSR:PIRSR622684-1,
FT ECO:0000256|PROSITE-ProRule:PRU00239"
SQ SEQUENCE 813 AA; 92592 MW; 4BD8C0F3204270EC CRC64;
MDAAALERDA VQFARLAVQR DHEGRYSEAV FYYKEAAQAL IYAEMAGSSL EHIQEKINEY
LERVQALHSA VQSKSADPLK SKHQLDLERA HFLVTQAFDE DEKGNVEDAI ELYTEAVDLC
LKTSYETADK TLQNKLKQLA RQALDRAEAL SEPLTKPLCK VKATNIKPKP PPTRTHFPLG
TNPFQERPQP FISPQSCDAQ GQRYTAEEIE VLRTTSKING IEYVPFMNID LRERFAYPMP
FCDRCGKLPL SPKQKAMFSK WVRPEDLTNN PTMIYTVSSF SIKQTIVSDC SFVASLAISA
AYERRFNKKL ITSIIYPQNK DGEPEYNPCG KYMVKLHLNG VPRKVIIDDQ LPVDHKGELL
CSYSNNKSEL WVSLIEKAYM KVMGGYDFPG SNSNIDLHAL TGWIPERIAM HSDSQSFSKD
NSFRMLYQRF HKGDVLITAS TGVMTEAEGE KWGLVPTHAY AVLDIREFKG LRFIQLKNPW
SHLRWKGRYS ENDVKNWTPE LQKYLNFDPR TAQKIDNGIF WISWDDLCQY YDVIYLSWNP
GLFKESTCIH STWDAKQGPV KDAYSLANNP QYKLEVQCPQ GGAAVWVLLS RHITDKDDFA
NNREFITMVV YKTDGKKVYY PADPPPYIDG IRINSPHYLT KIKLTTPGTH TFTLVVSQYE
KQNTIHYTVR VYSACSFTFS KIPSPYTVSK QINGKWSGQS AGGCGNFQET HKNNPIYQFH
IEKSGPLLIE LRGPRQYSVG FEVVTVSVVG DPGPHGFQRK SSGDYRCGFC YLELESIPAG
IYNIIPSTFL PKQEGPFFLD FNSVIPIKTT QLQ
//
