ID I3LC59_PIG Unreviewed; 493 AA.
AC I3LC59;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-DEC-2019, sequence version 3.
DT 27-MAR-2024, entry version 57.
DE SubName: Full=Solute carrier family 23 member 3 {ECO:0000313|Ensembl:ENSSSCP00000021632.3};
GN Name=SLC23A3 {ECO:0000313|Ensembl:ENSSSCP00000021632.3,
GN ECO:0000313|VGNC:VGNC:98319};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000021632.3, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000021632.3, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000021632.3,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSSCP00000021632.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004141}; Multi-
CC pass membrane protein {ECO:0000256|ARBA:ARBA00004141}.
CC -!- SIMILARITY: Belongs to the nucleobase:cation symporter-2 (NCS2) (TC
CC 2.A.40) family. {ECO:0000256|ARBA:ARBA00008821}.
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DR AlphaFoldDB; I3LC59; -.
DR STRING; 9823.ENSSSCP00000021632; -.
DR Ensembl; ENSSSCT00000031169.3; ENSSSCP00000021632.3; ENSSSCG00000029694.3.
DR VGNC; VGNC:98319; SLC23A3.
DR eggNOG; KOG1292; Eukaryota.
DR GeneTree; ENSGT00950000182953; -.
DR HOGENOM; CLU_017959_5_4_1; -.
DR InParanoid; I3LC59; -.
DR TreeFam; TF313272; -.
DR Proteomes; UP000008227; Chromosome 15.
DR Bgee; ENSSSCG00000029694; Expressed in adult mammalian kidney and 4 other cell types or tissues.
DR GO; GO:0016020; C:membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0022857; F:transmembrane transporter activity; IEA:InterPro.
DR GO; GO:0035344; P:hypoxanthine transport; IEA:Ensembl.
DR InterPro; IPR006043; NCS2.
DR PANTHER; PTHR11119:SF57; SOLUTE CARRIER FAMILY 23 MEMBER 3; 1.
DR PANTHER; PTHR11119; XANTHINE-URACIL / VITAMIN C PERMEASE FAMILY MEMBER; 1.
DR Pfam; PF00860; Xan_ur_permease; 2.
PE 3: Inferred from homology;
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 302..324
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 336..354
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 370..390
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REGION 1..28
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 401..424
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 453..493
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 401..417
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 493 AA; 52205 MW; 517375829A50726D CRC64;
MSQTPPKPHL LSVGSQAPPA PLPRPPAVQK PSSHSWVALC GPPPWGLSCL LALQHVLVLA
SLLCASHLLL LRSLPPEGLS YPPAQLLASS LFSCGMSTTL QTWMGSRLPL VQAPSLEFLI
PALVLTSQKL PLPNRTPGNS SLVLSPCRGA GCQGPELWNT SLREVSGAVV VSGLLQGTLG
LLGGPGHLFS HCGPLVLAPS LVVAGLSAHK EVALFCSTHW GLAWLTWAPA RYPHAPGGQL
RPLQPTLPSL PSGSSRSCLP PPRHRGFGCL TQAGSRRVAH LVGLLCVGLG FSPRLAQLLS
TIPLPVLGGV LGVTQAVVLS TGFSSFHMAD IDSGRNVFIV GFSIFMALLL PRWFREAPVL
LSTGWSPLDV LLRSLLTAPI FLAGLLGFLL ENTIPGTQLE RGLNQGLPSP FTDQEAQMPQ
KSREKSAQEY ELPFSIQNLC PCLPQPLRCL CPLPKDSGNE EGGSSEPGET ADLLPGFGEQ
RPGSSREELR SQL
//
