ID I3LH60_PIG Unreviewed; 183 AA.
AC I3LH60; A0A8D0PIG5;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 90.
DE RecName: Full=Ras-related protein Rap-2 {ECO:0000256|RuleBase:RU367057};
GN Name=RAP2C {ECO:0000313|Ensembl:ENSSSCP00000023405.1,
GN ECO:0000313|VGNC:VGNC:92090};
OS Sus scrofa (Pig).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Laurasiatheria; Artiodactyla; Suina; Suidae; Sus.
OX NCBI_TaxID=9823 {ECO:0000313|Ensembl:ENSSSCP00000023405.1, ECO:0000313|Proteomes:UP000008227};
RN [1] {ECO:0000313|Ensembl:ENSSSCP00000023405.1, ECO:0000313|Proteomes:UP000008227}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC STRAIN=Duroc {ECO:0000313|Ensembl:ENSSSCP00000023405.1,
RC ECO:0000313|Proteomes:UP000008227};
RG Porcine genome sequencing project;
RL Submitted (NOV-2009) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|EMBL:HDA52260.1}
RP NUCLEOTIDE SEQUENCE.
RX PubMed=30723633; DOI=.7717/peerj.6374;
RA Gilbert D.G.;
RT "Genes of the pig, Sus scrofa, reconstructed with EvidentialGene.";
RL PeerJ 7:E6374-E6374(2019).
RN [3] {ECO:0000313|Ensembl:ENSSSCP00000023405.1}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- FUNCTION: Small GTP-binding protein which cycles between a GDP-bound
CC inactive and a GTP-bound active form. {ECO:0000256|RuleBase:RU367057}.
CC -!- CATALYTIC ACTIVITY:
CC Reaction=GTP + H2O = GDP + H(+) + phosphate; Xref=Rhea:RHEA:19669,
CC ChEBI:CHEBI:15377, ChEBI:CHEBI:15378, ChEBI:CHEBI:37565,
CC ChEBI:CHEBI:43474, ChEBI:CHEBI:58189; EC=3.6.5.2;
CC Evidence={ECO:0000256|ARBA:ARBA00023421};
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004238}; Lipid-anchor
CC {ECO:0000256|ARBA:ARBA00004238}; Cytoplasmic side
CC {ECO:0000256|ARBA:ARBA00004238}. Recycling endosome membrane
CC {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057}; Lipid-
CC anchor {ECO:0000256|ARBA:ARBA00004523, ECO:0000256|RuleBase:RU367057};
CC Cytoplasmic side {ECO:0000256|ARBA:ARBA00004523,
CC ECO:0000256|RuleBase:RU367057}.
CC -!- PTM: Palmitoylated. {ECO:0000256|RuleBase:RU367057}.
CC -!- SIMILARITY: Belongs to the small GTPase superfamily. Ras family.
CC {ECO:0000256|RuleBase:RU367057}.
CC ---------------------------------------------------------------------------
CC Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms
CC Distributed under the Creative Commons Attribution (CC BY 4.0) License
CC ---------------------------------------------------------------------------
DR EMBL; DQIR01096784; HDA52260.1; -; Transcribed_RNA.
DR EMBL; DQIR01118456; HDA73932.1; -; Transcribed_RNA.
DR RefSeq; XP_005673976.1; XM_005673919.2.
DR RefSeq; XP_005673977.1; XM_005673920.2.
DR STRING; 9823.ENSSSCP00000023405; -.
DR PaxDb; 9823-ENSSSCP00000023405; -.
DR Ensembl; ENSSSCT00000024968.4; ENSSSCP00000023405.1; ENSSSCG00000026301.5.
DR Ensembl; ENSSSCT00005012335.1; ENSSSCP00005007237.1; ENSSSCG00005008193.1.
DR GeneID; 100511975; -.
DR KEGG; ssc:100511975; -.
DR CTD; 57826; -.
DR VGNC; VGNC:92090; RAP2C.
DR eggNOG; KOG0395; Eukaryota.
DR GeneTree; ENSGT00940000157245; -.
DR HOGENOM; CLU_041217_9_8_1; -.
DR OMA; NCDFVET; -.
DR OrthoDB; 8685at2759; -.
DR TreeFam; TF313014; -.
DR Reactome; R-SSC-6798695; Neutrophil degranulation.
DR Proteomes; UP000008227; Chromosome X.
DR Bgee; ENSSSCG00000026301; Expressed in ileum and 45 other cell types or tissues.
DR GO; GO:0005923; C:bicellular tight junction; IEA:Ensembl.
DR GO; GO:0044291; C:cell-cell contact zone; IEA:Ensembl.
DR GO; GO:0005829; C:cytosol; IEA:Ensembl.
DR GO; GO:0005886; C:plasma membrane; IBA:GO_Central.
DR GO; GO:0055038; C:recycling endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0003925; F:G protein activity; IEA:UniProtKB-EC.
DR GO; GO:0019003; F:GDP binding; IBA:GO_Central.
DR GO; GO:0005525; F:GTP binding; IBA:GO_Central.
DR GO; GO:0003924; F:GTPase activity; IBA:GO_Central.
DR GO; GO:0003713; F:transcription coactivator activity; IEA:Ensembl.
DR GO; GO:0090557; P:establishment of endothelial intestinal barrier; IEA:Ensembl.
DR GO; GO:0030336; P:negative regulation of cell migration; IBA:GO_Central.
DR GO; GO:0031954; P:positive regulation of protein autophosphorylation; IEA:UniProtKB-UniRule.
DR GO; GO:0032486; P:Rap protein signal transduction; IBA:GO_Central.
DR CDD; cd04176; Rap2; 1.
DR Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR InterPro; IPR027417; P-loop_NTPase.
DR InterPro; IPR041840; Rap2.
DR InterPro; IPR005225; Small_GTP-bd_dom.
DR InterPro; IPR001806; Small_GTPase.
DR InterPro; IPR020849; Small_GTPase_Ras-type.
DR NCBIfam; TIGR00231; small_GTP; 1.
DR PANTHER; PTHR24070; RAS, DI-RAS, AND RHEB FAMILY MEMBERS OF SMALL GTPASE SUPERFAMILY; 1.
DR PANTHER; PTHR24070:SF200; RAS-RELATED PROTEIN RAP-2C; 1.
DR Pfam; PF00071; Ras; 1.
DR PRINTS; PR00449; RASTRNSFRMNG.
DR SMART; SM00175; RAB; 1.
DR SMART; SM00173; RAS; 1.
DR SMART; SM00174; RHO; 1.
DR SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
DR PROSITE; PS51419; RAB; 1.
DR PROSITE; PS51421; RAS; 1.
DR PROSITE; PS51420; RHO; 1.
PE 1: Evidence at protein level;
KW Endosome {ECO:0000256|RuleBase:RU367057};
KW GTP-binding {ECO:0000256|RuleBase:RU367057};
KW Lipoprotein {ECO:0000256|RuleBase:RU367057};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|RuleBase:RU367057};
KW Methylation {ECO:0000256|RuleBase:RU367057};
KW Nucleotide-binding {ECO:0000256|ARBA:ARBA00022741,
KW ECO:0000256|RuleBase:RU367057};
KW Palmitate {ECO:0000256|ARBA:ARBA00023139, ECO:0000256|RuleBase:RU367057};
KW Prenylation {ECO:0000256|RuleBase:RU367057};
KW Proteomics identification {ECO:0007829|PeptideAtlas:I3LH60};
KW Reference proteome {ECO:0000313|Proteomes:UP000008227}.
SQ SEQUENCE 183 AA; 20759 MW; 67632ACF76638324 CRC64;
MREYKVVVLG SGGVGKSALT VQFVTGTFIE KYDPTIEDFY RKEIEVDSSP SVLEILDTAG
TEQFASMRDL YIKNGQGFIL VYSLVNQQSF QDIKPMRDQI VRVKRYEKVP LILVGNKVDL
EPEREVMSSE GRALAQEWGC PFMETSAKSK SMVDELFAEI VRQMNYSSLP EKQDQCCTTC
IVQ
//
