ID I3LXV2_ICTTR Unreviewed; 691 AA.
AC I3LXV2;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 55.
DE SubName: Full=Erythrocyte membrane protein band 4.2 {ECO:0000313|Ensembl:ENSSTOP00000000933.3};
GN Name=EPB42 {ECO:0000313|Ensembl:ENSSTOP00000000933.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000000933.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000000933.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the transglutaminase superfamily.
CC Transglutaminase family. {ECO:0000256|ARBA:ARBA00005968}.
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DR EMBL; AGTP01002344; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005316533.1; XM_005316476.1.
DR AlphaFoldDB; I3LXV2; -.
DR STRING; 43179.ENSSTOP00000000933; -.
DR Ensembl; ENSSTOT00000001044.3; ENSSTOP00000000933.3; ENSSTOG00000001041.3.
DR eggNOG; ENOG502R9T9; Eukaryota.
DR GeneTree; ENSGT01050000244866; -.
DR HOGENOM; CLU_013435_3_0_1; -.
DR InParanoid; I3LXV2; -.
DR OrthoDB; 5344745at2759; -.
DR TreeFam; TF324278; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0170014; C:ankyrin-1 complex; IEA:Ensembl.
DR GO; GO:0030863; C:cortical cytoskeleton; IEA:Ensembl.
DR GO; GO:0003810; F:protein-glutamine gamma-glutamyltransferase activity; IEA:InterPro.
DR GO; GO:0000902; P:cell morphogenesis; IEA:Ensembl.
DR GO; GO:0020027; P:hemoglobin metabolic process; IEA:Ensembl.
DR GO; GO:0060586; P:multicellular organismal-level iron ion homeostasis; IEA:Ensembl.
DR GO; GO:0048536; P:spleen development; IEA:Ensembl.
DR Gene3D; 2.60.40.10; Immunoglobulins; 3.
DR Gene3D; 3.90.260.10; Transglutaminase-like; 1.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR014756; Ig_E-set.
DR InterPro; IPR038765; Papain-like_cys_pep_sf.
DR InterPro; IPR002931; Transglutaminase-like.
DR InterPro; IPR036985; Transglutaminase-like_sf.
DR InterPro; IPR023608; Transglutaminase_animal.
DR InterPro; IPR008958; Transglutaminase_C.
DR InterPro; IPR036238; Transglutaminase_C_sf.
DR InterPro; IPR001102; Transglutaminase_N.
DR PANTHER; PTHR11590:SF44; PROTEIN 4.2; 1.
DR PANTHER; PTHR11590; PROTEIN-GLUTAMINE GAMMA-GLUTAMYLTRANSFERASE; 1.
DR Pfam; PF00927; Transglut_C; 2.
DR Pfam; PF01841; Transglut_core; 1.
DR Pfam; PF00868; Transglut_N; 1.
DR PIRSF; PIRSF000459; TGM_EBP42; 1.
DR SMART; SM00460; TGc; 1.
DR SUPFAM; SSF54001; Cysteine proteinases; 1.
DR SUPFAM; SSF81296; E set domains; 1.
DR SUPFAM; SSF49309; Transglutaminase, two C-terminal domains; 2.
PE 3: Inferred from homology;
KW Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT DOMAIN 259..353
FT /note="Transglutaminase-like"
FT /evidence="ECO:0000259|SMART:SM00460"
SQ SEQUENCE 691 AA; 77593 MW; 6AAAB9B88180E134 CRC64;
MGQALDIESC DFQAAKNNKE HHTSAISSRH LIVRRGQPFT ISLHFRTSVH RFLPTLKKVA
LIAQTGQQPS KTNGTQVTLP ISTMGDQKWS AAVEERDAHF WAISVTTSAD AVIGHYSLLL
QVLGEKEHLL GQFTVLFNPW SREDDVFLPN EAQRSEYVLN QNGLIYLGTA DCIQEEPWDF
GQFEKDVMDI SLGLLGMDKH MEKWSQPVHV AHVLGTLLQT LKQRSVLPIP QAQTAQEEAL
LNKRRGSVPI LRQWITGQGR PVYESQAWVL AAVACTVLRC LGIPARVVTT YASAQGTHGD
LLVDEYYNEE GIQNGEGQRG RIWIFQTSTE CWMTRPDFRY PHYAGWQILY PYVPNKGEGL
GSCDLVPVKA VKDGILELTP AVSDLFAAVN ASCVVWKCCE DGKLELTNSN TKYVGNNIST
KVVGSDRCED ITQNYKYPAG SLQEKEVMER VQEKRMKQWK PNGIRPPSDK WADPLYLFLE
APSSFPLRGD AQLSVILFNP SDQEKEVQLV IGVQAVYYNG VFAAKLWRKK QFLTLSANLD
MRITISLSFS HFERNPPENS FLRLTVMATH SESGLSCFAQ EDVAICRPHL VIQMPETAKQ
YQPLTASISI HNSLDSPMMD CMISIFGRGL IHKERRYGLG SVWPGNTLST QFKFTPTQLG
LQRLTVEMDC NMFQNLISHR SITVVAPELS A
//
