ID   I3LZE4_ICTTR            Unreviewed;       623 AA.
AC   I3LZE4;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   22-NOV-2017, sequence version 2.
DT   27-MAR-2024, entry version 62.
DE   RecName: Full=TOX high mobility group box family member 4 {ECO:0000256|ARBA:ARBA00013298};
GN   Name=TOX4 {ECO:0000313|Ensembl:ENSSTOP00000001689.3};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000001689.3, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000001689.3}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- SUBCELLULAR LOCATION: Nucleus {ECO:0000256|ARBA:ARBA00004123}.
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DR   EMBL; AGTP01114835; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3LZE4; -.
DR   STRING; 43179.ENSSTOP00000001689; -.
DR   Ensembl; ENSSTOT00000001895.3; ENSSTOP00000001689.3; ENSSTOG00000001894.3.
DR   GeneTree; ENSGT00940000154888; -.
DR   HOGENOM; CLU_030650_0_0_1; -.
DR   InParanoid; I3LZE4; -.
DR   TreeFam; TF106481; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   GO; GO:0000785; C:chromatin; IEA:Ensembl.
DR   GO; GO:0000781; C:chromosome, telomeric region; IEA:Ensembl.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0072357; C:PTW/PP1 phosphatase complex; IEA:Ensembl.
DR   GO; GO:0003677; F:DNA binding; IEA:UniProtKB-UniRule.
DR   CDD; cd21995; HMG-box_TOX-like; 1.
DR   Gene3D; 1.10.30.10; High mobility group box domain; 1.
DR   InterPro; IPR009071; HMG_box_dom.
DR   InterPro; IPR036910; HMG_box_dom_sf.
DR   PANTHER; PTHR45781; AGAP000281-PA; 1.
DR   PANTHER; PTHR45781:SF2; TOX HIGH MOBILITY GROUP BOX FAMILY MEMBER 4; 1.
DR   Pfam; PF00505; HMG_box; 1.
DR   PRINTS; PR00886; HIGHMOBLTY12.
DR   SMART; SM00398; HMG; 1.
DR   SUPFAM; SSF47095; HMG-box; 1.
DR   PROSITE; PS50118; HMG_BOX_2; 1.
PE   4: Predicted;
KW   DNA-binding {ECO:0000256|PROSITE-ProRule:PRU00267};
KW   Nucleus {ECO:0000256|ARBA:ARBA00023242, ECO:0000256|PROSITE-
KW   ProRule:PRU00267}; Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          227..295
FT                   /note="HMG box"
FT                   /evidence="ECO:0000259|PROSITE:PS50118"
FT   DNA_BIND        227..295
FT                   /note="HMG box"
FT                   /evidence="ECO:0000256|PROSITE-ProRule:PRU00267"
FT   REGION          159..231
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..339
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        159..187
FT                   /note="Polar residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        313..328
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ   SEQUENCE   623 AA;  66338 MW;  AFC28AE905E3B212 CRC64;
     MSGSESFPGG NDNYLTITGP SHPFLSGAET FHTPSLGDEE FEIPPISLDS DPSLAVSDVV
     GHFDDLADPS SSQDGSFSAQ YGVQTLDMPV GMTHGLMEQG GGLLSGGLTM DLDHSIGTQY
     SANPPVTIDV PMTDMTSGLM GHSQLTTIDQ SELSSQLGLS LGGSTILPPA QSPEDRLSTT
     PSPTSSLHED GVEDFRRQLP SQKTVVVEAG KKQKAPKKRK KKDPNEPQKP VSAYALFFRD
     TQAAIKGQNP NATFGEVSKI VASMWDSLGE EQKQVYKRKT EAAKKEYLKA LAAYKDNQEC
     QATVETVELD PVPPSQTPSP PPVATVDPAS PAPASTESPA LSPCIVVNST LSSYVANQAS
     SGAGGQPNIT KLIITKQMLP SSITMSQGGM VTVIPATVVT SRGLQLGQTS TATIQPSQQA
     QIVTRSVLQA AAAAAASMQL PPPRLQPPPL QQMPQPPTQQ QVTILQQPPP LQAMQQPPPQ
     KVRINLQQQP PPLQSKIVPP PTLKMQTTLV PPAVESSPER PMNSSPEAHT VEATSPETIC
     EMITDVVPEV ESPSQMDVEL VSGSPVTLSP QPRCVRSGCE NPPVVSKDWD NEYCSNECVV
     KHCRDVFLAW VASRNSNTVV FVK
//