ID I3M2I9_ICTTR Unreviewed; 579 AA.
AC I3M2I9;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 63.
DE SubName: Full=Synapsin III {ECO:0000313|Ensembl:ENSSTOP00000003201.2};
GN Name=SYN3 {ECO:0000313|Ensembl:ENSSTOP00000003201.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000003201.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000003201.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SIMILARITY: Belongs to the synapsin family.
CC {ECO:0000256|ARBA:ARBA00008243}.
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DR EMBL; AGTP01024473; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024474; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024475; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024476; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024477; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024478; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024480; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024481; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01024482; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005322374.1; XM_005322317.1.
DR AlphaFoldDB; I3M2I9; -.
DR STRING; 43179.ENSSTOP00000003201; -.
DR Ensembl; ENSSTOT00000003575.2; ENSSTOP00000003201.2; ENSSTOG00000003581.2.
DR GeneID; 101959221; -.
DR CTD; 8224; -.
DR eggNOG; KOG3895; Eukaryota.
DR GeneTree; ENSGT00940000155415; -.
DR HOGENOM; CLU_010582_3_0_1; -.
DR InParanoid; I3M2I9; -.
DR OMA; GPHKCIL; -.
DR OrthoDB; 5487039at2759; -.
DR TreeFam; TF319919; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0098978; C:glutamatergic synapse; IEA:Ensembl.
DR GO; GO:0014069; C:postsynaptic density; IEA:Ensembl.
DR GO; GO:0030672; C:synaptic vesicle membrane; IEA:Ensembl.
DR GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR GO; GO:0007269; P:neurotransmitter secretion; IEA:InterPro.
DR GO; GO:0097091; P:synaptic vesicle clustering; IEA:Ensembl.
DR Gene3D; 3.40.50.20; -; 1.
DR Gene3D; 3.30.1490.20; ATP-grasp fold, A domain; 1.
DR Gene3D; 3.30.470.20; ATP-grasp fold, B domain; 1.
DR InterPro; IPR013815; ATP_grasp_subdomain_1.
DR InterPro; IPR016185; PreATP-grasp_dom_sf.
DR InterPro; IPR001359; Synapsin.
DR InterPro; IPR020898; Synapsin_ATP-bd_dom.
DR InterPro; IPR019735; Synapsin_CS.
DR InterPro; IPR019736; Synapsin_P_site.
DR InterPro; IPR020897; Synapsin_pre-ATP-grasp_dom.
DR PANTHER; PTHR10841; SYNAPSIN; 1.
DR PANTHER; PTHR10841:SF27; SYNAPSIN-3; 1.
DR Pfam; PF02078; Synapsin; 1.
DR Pfam; PF02750; Synapsin_C; 1.
DR Pfam; PF10581; Synapsin_N; 1.
DR PRINTS; PR01368; SYNAPSIN.
DR SUPFAM; SSF56059; Glutathione synthetase ATP-binding domain-like; 1.
DR SUPFAM; SSF52440; PreATP-grasp domain; 1.
DR PROSITE; PS00415; SYNAPSIN_1; 1.
DR PROSITE; PS00416; SYNAPSIN_2; 1.
PE 3: Inferred from homology;
KW Phosphoprotein {ECO:0000256|ARBA:ARBA00022553};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Synapse {ECO:0000256|ARBA:ARBA00023018}.
FT DOMAIN 89..190
FT /note="Synapsin pre-ATP-grasp"
FT /evidence="ECO:0000259|Pfam:PF02078"
FT DOMAIN 192..394
FT /note="Synapsin ATP-binding"
FT /evidence="ECO:0000259|Pfam:PF02750"
FT REGION 18..86
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT REGION 399..566
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 18..39
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 50..75
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 429..443
FT /note="Pro residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 444..554
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
SQ SEQUENCE 579 AA; 63194 MW; C7260113FFD66AF0 CRC64;
MNFLRRRLSD SSFVANLPNG YMTDLQRPDS STSSPASPAM ERRHPQPLAA SFSSPGSSLF
SSFSSAMKQT PQASPGLTEP PGPSTPVVQR PRILLVIDDA HTDWSKYFHG KRVNGEIEIR
VEQAEFSELN LAAYVTGGCM VDMQVVRNGT KVVRSFKPDF ILVRQHAYSM ALGEDYRSLV
IGLQYGGLPA VNSLYSVYNF CSKPWVFSQL IKIFHSLGPE KFPLVEQTFF PNHKPMLTAP
HFPVVIKLGH AHAGMGKIKV ENQHDYQDIT SVVAMAKTYA TTEAFIDSKY DIRIQKIGSN
YKAYMRTSIS GNWKANTGSA MLEQVAMTER YRLWVDSCSE MFGGLDICAV KAVHSKDGRD
YIIEVMDSSM PLIGEHVEED KQLMADLVVS KMSQFLMPGG TVPSPLKPWA PQTKPAKSPG
QGQLGPQLGQ PQPRPPPQGG PRQAQSPQTP RSGSPSQQRL SPQGQQPLSP QSGSPQQQRS
PGSPQLSRAS GGSSPNQASK PGTSLASQPR PPVQGRSTSQ QGDESKKTAA PHPHLNKSQS
LTNSLSTSDA SQRGTPSEDE AKAETIRNLR KSFASLFSD
//
