ID I3M604_ICTTR Unreviewed; 579 AA.
AC I3M604;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 11-JUL-2012, sequence version 1.
DT 27-MAR-2024, entry version 71.
DE SubName: Full=Membrane frizzled-related protein {ECO:0000313|Ensembl:ENSSTOP00000004836.2};
GN Name=MFRP {ECO:0000313|Ensembl:ENSSTOP00000004836.2};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000004836.2, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000004836.2}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004401};
CC Single-pass type II membrane protein {ECO:0000256|ARBA:ARBA00004401}.
CC -!- CAUTION: Lacks conserved residue(s) required for the propagation of
CC feature annotation. {ECO:0000256|PROSITE-ProRule:PRU00090}.
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DR EMBL; AGTP01052994; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005328429.1; XM_005328372.1.
DR AlphaFoldDB; I3M604; -.
DR Ensembl; ENSSTOT00000005404.3; ENSSTOP00000004836.2; ENSSTOG00000005406.3.
DR GeneID; 101971128; -.
DR CTD; 83552; -.
DR eggNOG; KOG3577; Eukaryota.
DR eggNOG; KOG4292; Eukaryota.
DR GeneTree; ENSGT00940000154525; -.
DR HOGENOM; CLU_032137_0_0_1; -.
DR OMA; WMCDLWR; -.
DR OrthoDB; 5317198at2759; -.
DR TreeFam; TF316506; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-SubCell.
DR CDD; cd07066; CRD_FZ; 1.
DR CDD; cd00041; CUB; 2.
DR CDD; cd00112; LDLa; 2.
DR Gene3D; 1.10.2000.10; Frizzled cysteine-rich domain; 1.
DR Gene3D; 4.10.400.10; Low-density Lipoprotein Receptor; 2.
DR Gene3D; 2.60.120.290; Spermadhesin, CUB domain; 2.
DR InterPro; IPR000859; CUB_dom.
DR InterPro; IPR020067; Frizzled_dom.
DR InterPro; IPR036790; Frizzled_dom_sf.
DR InterPro; IPR036055; LDL_receptor-like_sf.
DR InterPro; IPR023415; LDLR_class-A_CS.
DR InterPro; IPR002172; LDrepeatLR_classA_rpt.
DR InterPro; IPR035914; Sperma_CUB_dom_sf.
DR PANTHER; PTHR24251:SF36; MEMBRANE FRIZZLED-RELATED PROTEIN; 1.
DR PANTHER; PTHR24251; OVOCHYMASE-RELATED; 1.
DR Pfam; PF00431; CUB; 2.
DR Pfam; PF01392; Fz; 1.
DR Pfam; PF00057; Ldl_recept_a; 1.
DR PRINTS; PR00261; LDLRECEPTOR.
DR SMART; SM00042; CUB; 2.
DR SMART; SM00063; FRI; 1.
DR SMART; SM00192; LDLa; 2.
DR SUPFAM; SSF63501; Frizzled cysteine-rich domain; 1.
DR SUPFAM; SSF57424; LDL receptor-like module; 2.
DR SUPFAM; SSF49854; Spermadhesin, CUB domain; 2.
DR PROSITE; PS01180; CUB; 2.
DR PROSITE; PS50038; FZ; 1.
DR PROSITE; PS01209; LDLRA_1; 1.
DR PROSITE; PS50068; LDLRA_2; 2.
PE 4: Predicted;
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157, ECO:0000256|PROSITE-
KW ProRule:PRU00124}; Membrane {ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|SAM:Phobius}.
FT TRANSMEM 65..89
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 143..252
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 300..413
FT /note="CUB"
FT /evidence="ECO:0000259|PROSITE:PS01180"
FT DOMAIN 461..579
FT /note="FZ"
FT /evidence="ECO:0000259|PROSITE:PS50038"
FT REGION 97..141
FT /note="Disordered"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT COMPBIAS 105..137
FT /note="Polar residues"
FT /evidence="ECO:0000256|SAM:MobiDB-lite"
FT DISULFID 259..271
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 266..284
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 278..293
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 420..432
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 427..445
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
FT DISULFID 439..454
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00124"
SQ SEQUENCE 579 AA; 62177 MW; 6175AA4E88ADC7C5 CRC64;
MKEYSDVILC MEATELSKTE FCNPAFEPEA GLPGPSAALR QDASHNIQAP WHGRRPRGLQ
PDCHFSWLCI LLLASLLLLL LGLLAAIILS QLPAAPPPGA TKSPLPAQGL TTTTTPTTST
STTSSATSGQ QGADASPAHQ ATCGGLLPGP RGFFSSPNYP DPYPPNAHCV WHIQVATDHT
IQLKIEALSV EGVAACLFDR LEISPEPEGP LLRVCGKVPP PTLNTNASRL QVAFVSDSSV
EGSGFQAWYQ AVAPGHGSCA HEEFHCDQLV CLLPDSVCDG FANCADGSDE TNCSAKLLGC
GGNLTGLQGT FSTPSDLQQH PHQQLCTWHI SVPVGHGIEL QFWNFSLEAQ DECKFDYVEV
YETSSSGALS LLGRFCGAET PPHLVSSHHE LAVLFRTDHS ISSGGFSATF KAFNATENPC
GPRKFLCQNG GCRDLQWMCD LWRDCIDGNN DKNCSSPLLP PPELACEPVQ VEMCIGLSYN
TTAFPNIWVG MATQEEVVDV LRGYKSLTSL PCYQNFRRLL CGLLVPRCTL LGSVLPPCRS
VCQEAERQCQ SGLALLGTPW PFNCNRLPEA AGLEACAQP
//
