ID I3MBG3_ICTTR Unreviewed; 724 AA.
AC I3MBG3;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=Transient receptor potential cation channel subfamily V member 5 {ECO:0000313|Ensembl:ENSSTOP00000007474.3};
GN Name=TRPV5 {ECO:0000313|Ensembl:ENSSTOP00000007474.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000007474.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000007474.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000256|ARBA:ARBA00004651};
CC Multi-pass membrane protein {ECO:0000256|ARBA:ARBA00004651}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01044922; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR RefSeq; XP_005326661.1; XM_005326604.2.
DR AlphaFoldDB; I3MBG3; -.
DR STRING; 43179.ENSSTOP00000007474; -.
DR Ensembl; ENSSTOT00000008340.3; ENSSTOP00000007474.3; ENSSTOG00000008339.3.
DR GeneID; 101961826; -.
DR CTD; 56302; -.
DR eggNOG; KOG3676; Eukaryota.
DR GeneTree; ENSGT00940000161809; -.
DR HOGENOM; CLU_012795_2_0_1; -.
DR InParanoid; I3MBG3; -.
DR OrthoDB; 1003028at2759; -.
DR TreeFam; TF314711; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0016324; C:apical plasma membrane; IEA:Ensembl.
DR GO; GO:0034704; C:calcium channel complex; IEA:Ensembl.
DR GO; GO:0005262; F:calcium channel activity; IEA:Ensembl.
DR GO; GO:0055074; P:calcium ion homeostasis; IEA:Ensembl.
DR GO; GO:0035809; P:regulation of urine volume; IEA:Ensembl.
DR CDD; cd22296; CBD_TRPV5_C; 1.
DR CDD; cd22192; TRPV5-6; 1.
DR Gene3D; 1.25.40.20; Ankyrin repeat-containing domain; 1.
DR InterPro; IPR002110; Ankyrin_rpt.
DR InterPro; IPR036770; Ankyrin_rpt-contain_sf.
DR InterPro; IPR005821; Ion_trans_dom.
DR InterPro; IPR024862; TRPV.
DR InterPro; IPR008346; TRPV5.
DR InterPro; IPR008344; TRPV5/TRPV6.
DR NCBIfam; TIGR00870; trp; 1.
DR PANTHER; PTHR10582:SF11; TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL SUBFAMILY V MEMBER 5; 1.
DR PANTHER; PTHR10582; TRANSIENT RECEPTOR POTENTIAL ION CHANNEL PROTEIN; 1.
DR Pfam; PF00023; Ank; 1.
DR Pfam; PF12796; Ank_2; 1.
DR Pfam; PF00520; Ion_trans; 1.
DR PRINTS; PR01415; ANKYRIN.
DR PRINTS; PR01765; ECACCHANNEL.
DR PRINTS; PR01767; ECACCHANNEL2.
DR SMART; SM00248; ANK; 4.
DR SUPFAM; SSF48403; Ankyrin repeat; 1.
DR PROSITE; PS50297; ANK_REP_REGION; 2.
DR PROSITE; PS50088; ANK_REPEAT; 2.
PE 4: Predicted;
KW ANK repeat {ECO:0000256|PROSITE-ProRule:PRU00023};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT TRANSMEM 322..346
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 419..439
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 445..463
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 484..507
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 551..573
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT REPEAT 111..143
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT REPEAT 157..189
FT /note="ANK"
FT /evidence="ECO:0000256|PROSITE-ProRule:PRU00023"
FT DOMAIN 385..582
FT /note="Ion transport"
FT /evidence="ECO:0000259|Pfam:PF00520"
SQ SEQUENCE 724 AA; 82124 MW; 91506E7831FAC0CC CRC64;
MGAKGPWIQL QKFLASWLVG EQDWDQHLDQ VYMLQQKRIW ESPLLQAAKE NDLCTLKKLL
LEQNCDFRQR GALGETALHV AALYDNLEAA MVLMEAAPDL VQEPTVCEPF IGQTALHIAV
MNQNVNLVRA LLSHGASVSA RATGTAFQRS PHNLIYYGEH PLSFAACVGS EEIVRLLIEH
GADIRAQDSL GNTVLHILIL QPNKTFACQM YNLLLSYDGG DHLQPLELVP NHQGLTPFKL
AGVEGNTVMF QHLMQRRKHI QWTYGPLTST LYDLTEIDSW GEELSFLELV VSSKKREARQ
ILEQTPVKEL VSFKWKKYGQ PYFCILGALY ILYMMCFTTC CVYRPLKFRV GNRTNPRDNI
IFQQKLLQEA YVTYQDHIRL VGELVTVIGA VIILLLEIPD IFRVGASRYF GQTILGGPFH
VIIITYASLV LVTMVMRLTN TNGEVVPISL ALVLGWCSVM YFARGFQMLG PFTIMIQKMI
FGDLMRFCWL MAMVILGFAS AFCIIFQTED PANLGEFSDY PTALFSTFEL FLTIIDGPAN
YNVDLPFMYN LAYAAFAIIA TLLMLNLFIA MMGDTHWRVA QERDELWRAQ VVATTVMLER
KMPRFLWPRS GICGCEYGLG DRWFLRVENH HDQNPLRVLR YVEAFKCSDK EDGQEQLSEK
QPSVTEVGTL ARASLVLQTP SLSRTTSQSS NSHRGWEILR RNTLAHLNLG LDLGEGDGEE
VYHF
//
