ID I3MD72_ICTTR Unreviewed; 292 AA.
AC I3MD72;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 67.
DE SubName: Full=HLA class II histocompatibility antigen, DM alpha chain {ECO:0000313|Ensembl:ENSSTOP00000008292.3};
GN Name=HLA-DMA {ECO:0000313|Ensembl:ENSSTOP00000008292.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000008292.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000008292.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Membrane {ECO:0000256|ARBA:ARBA00004479}; Single-
CC pass type I membrane protein {ECO:0000256|ARBA:ARBA00004479}.
CC -!- SIMILARITY: Belongs to the MHC class II family.
CC {ECO:0000256|ARBA:ARBA00007394, ECO:0000256|RuleBase:RU004238}.
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DR EMBL; AGTP01011073; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MD72; -.
DR STRING; 43179.ENSSTOP00000008292; -.
DR Ensembl; ENSSTOT00000009243.3; ENSSTOP00000008292.3; ENSSTOG00000009246.3.
DR GeneTree; ENSGT00940000161157; -.
DR HOGENOM; CLU_069380_1_0_1; -.
DR InParanoid; I3MD72; -.
DR TreeFam; TF333797; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0009986; C:cell surface; IEA:Ensembl.
DR GO; GO:0031902; C:late endosome membrane; IEA:Ensembl.
DR GO; GO:0005765; C:lysosomal membrane; IEA:Ensembl.
DR GO; GO:0042613; C:MHC class II protein complex; IEA:UniProtKB-KW.
DR GO; GO:0023026; F:MHC class II protein complex binding; IEA:Ensembl.
DR GO; GO:0002250; P:adaptive immune response; IEA:UniProtKB-KW.
DR GO; GO:0002503; P:peptide antigen assembly with MHC class II protein complex; IEA:Ensembl.
DR GO; GO:0002682; P:regulation of immune system process; IEA:UniProt.
DR Gene3D; 2.60.40.10; Immunoglobulins; 1.
DR InterPro; IPR007110; Ig-like_dom.
DR InterPro; IPR036179; Ig-like_dom_sf.
DR InterPro; IPR013783; Ig-like_fold.
DR InterPro; IPR003006; Ig/MHC_CS.
DR InterPro; IPR003597; Ig_C1-set.
DR InterPro; IPR011162; MHC_I/II-like_Ag-recog.
DR InterPro; IPR014745; MHC_II_a/b_N.
DR InterPro; IPR001003; MHC_II_a_N.
DR PANTHER; PTHR19944:SF50; HLA CLASS II HISTOCOMPATIBILITY ANTIGEN, DM ALPHA CHAIN; 1.
DR PANTHER; PTHR19944; MHC CLASS II-RELATED; 1.
DR Pfam; PF07654; C1-set; 1.
DR Pfam; PF00993; MHC_II_alpha; 1.
DR SMART; SM00407; IGc1; 1.
DR SMART; SM00920; MHC_II_alpha; 1.
DR SUPFAM; SSF48726; Immunoglobulin; 1.
DR SUPFAM; SSF54452; MHC antigen-recognition domain; 1.
DR PROSITE; PS50835; IG_LIKE; 1.
DR PROSITE; PS00290; IG_MHC; 1.
PE 3: Inferred from homology;
KW Adaptive immunity {ECO:0000256|ARBA:ARBA00023130};
KW Glycoprotein {ECO:0000256|ARBA:ARBA00023180};
KW Immunity {ECO:0000256|ARBA:ARBA00022859};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW MHC II {ECO:0000256|ARBA:ARBA00023182};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Signal {ECO:0000256|SAM:SignalP};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}.
FT SIGNAL 1..26
FT /evidence="ECO:0000256|SAM:SignalP"
FT CHAIN 27..292
FT /evidence="ECO:0000256|SAM:SignalP"
FT /id="PRO_5012836250"
FT TRANSMEM 234..254
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 127..213
FT /note="Ig-like"
FT /evidence="ECO:0000259|PROSITE:PS50835"
SQ SEQUENCE 292 AA; 32471 MW; 0EA5DCCD36A20CA8 CRC64;
MDHEQSQGAT LLQLLRLLWL LPHSWATPAA PAPLWRDDLQ NHTFRHTVFC QDGSPSIGLT
ETYDEDLLFS FDFSRNTRVP RLPEFADWAQ DQRDASAIVF DKGFCEAMIE KIGPQLEGQI
PVSRGYPVAE VFTMKPLEFG KPNTLVCFIS NLFPPTLTVN WQHNSVPVEG VGPTFVSAMD
GLTFQAFSYL NFTPEPYDLF SCIVTHEIDR HTTFAYWVPQ NALPSDFLEN VLCGIAFVLG
VLGIVVGTVL IIYFRKPCSG GMSSGGMGEP DGVVHAWACQ DHPVAWGRVS SD
//
