ID   I3MET8_ICTTR            Unreviewed;       261 AA.
AC   I3MET8;
DT   11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT   11-JUL-2012, sequence version 1.
DT   27-MAR-2024, entry version 50.
DE   RecName: Full=Maspardin {ECO:0000256|ARBA:ARBA00020148};
GN   Name=Spg21 {ECO:0000313|Ensembl:ENSSTOP00000009058.2};
OS   Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS   tridecemlineatus).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC   Xerinae; Marmotini; Ictidomys.
OX   NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000009058.2, ECO:0000313|Proteomes:UP000005215};
RN   [1] {ECO:0000313|Proteomes:UP000005215}
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG   The Broad Institute Genome Assembly & Analysis Group;
RG   Computational R&D Group;
RG   and Sequencing Platform;
RA   Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA   MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT   "The Draft Genome of Spermophilus tridecemlineatus.";
RL   Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN   [2] {ECO:0000313|Ensembl:ENSSTOP00000009058.2}
RP   IDENTIFICATION.
RG   Ensembl;
RL   Submitted (NOV-2023) to UniProtKB.
CC   -!- FUNCTION: May play a role as a negative regulatory factor in CD4-
CC       dependent T-cell activation. {ECO:0000256|ARBA:ARBA00002271}.
CC   -!- SUBUNIT: Interacts with CD4. Interacts with ALDH16A1.
CC       {ECO:0000256|ARBA:ARBA00011379}.
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DR   EMBL; AGTP01003205; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AGTP01003206; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   AlphaFoldDB; I3MET8; -.
DR   Ensembl; ENSSTOT00000010098.3; ENSSTOP00000009058.2; ENSSTOG00000010101.3.
DR   eggNOG; ENOG502QPSD; Eukaryota.
DR   GeneTree; ENSGT00390000007857; -.
DR   HOGENOM; CLU_052260_0_0_1; -.
DR   OMA; MELDKVH; -.
DR   TreeFam; TF105253; -.
DR   Proteomes; UP000005215; Unassembled WGS sequence.
DR   Gene3D; 3.40.50.1820; alpha/beta hydrolase; 1.
DR   InterPro; IPR029058; AB_hydrolase.
DR   InterPro; IPR000073; AB_hydrolase_1.
DR   InterPro; IPR026151; Maspardin.
DR   PANTHER; PTHR15913; ACID CLUSTER PROTEIN 33; 1.
DR   PANTHER; PTHR15913:SF0; MASPARDIN; 1.
DR   Pfam; PF00561; Abhydrolase_1; 1.
DR   SUPFAM; SSF53474; alpha/beta-Hydrolases; 1.
PE   4: Predicted;
KW   Cytoplasm {ECO:0000256|ARBA:ARBA00022490};
KW   Reference proteome {ECO:0000313|Proteomes:UP000005215}.
FT   DOMAIN          87..163
FT                   /note="AB hydrolase-1"
FT                   /evidence="ECO:0000259|Pfam:PF00561"
SQ   SEQUENCE   261 AA;  29641 MW;  A52C56D1A26B74C1 CRC64;
     MGEIKVSPDY NWFRSTVPLK KIIVDDDDSK IWSLYDAGPR SIRCPLIFLP PVSGTADVFF
     RQILALTGWG YRVIALQYPV YWDHLEFCDG FRKLLDHLQL DKVHLFGASL GGFLAQKFAE
     YTHKSPRVHS LILCNSFSDT SIFNQTWTAN SFWLMPAFML KKIVLGNFSS GPVDPMMADA
     IDFMVDRLES LGQSELASRL TLNCQNSYVE PHKIRDIPVT IMDIHLLQFH GTKYAAIDPS
     MVSAEELEVQ KGNLSVSQEE Q
//