ID I3MH24_ICTTR Unreviewed; 529 AA.
AC I3MH24;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 51.
DE SubName: Full=Mucolipin-2 {ECO:0000313|Ensembl:ENSSTOP00000010143.3};
GN Name=MCOLN2 {ECO:0000313|Ensembl:ENSSTOP00000010143.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010143.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000010143.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
CC -!- SUBCELLULAR LOCATION: Endosome membrane
CC {ECO:0000256|ARBA:ARBA00004337}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004337}. Membrane
CC {ECO:0000256|ARBA:ARBA00004141}; Multi-pass membrane protein
CC {ECO:0000256|ARBA:ARBA00004141}.
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DR EMBL; AGTP01075057; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075058; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075059; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075060; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075061; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075062; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075063; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075064; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075065; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01075066; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MH24; -.
DR STRING; 43179.ENSSTOP00000010143; -.
DR Ensembl; ENSSTOT00000011305.3; ENSSTOP00000010143.3; ENSSTOG00000011302.3.
DR eggNOG; KOG3733; Eukaryota.
DR GeneTree; ENSGT00950000183036; -.
DR HOGENOM; CLU_020945_0_1_1; -.
DR InParanoid; I3MH24; -.
DR TreeFam; TF317783; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0010008; C:endosome membrane; IEA:UniProtKB-SubCell.
DR GO; GO:0005886; C:plasma membrane; IEA:UniProtKB-KW.
DR GO; GO:0055037; C:recycling endosome; IEA:Ensembl.
DR GO; GO:0042802; F:identical protein binding; IEA:Ensembl.
DR GO; GO:0005261; F:monoatomic cation channel activity; IEA:InterPro.
DR GO; GO:1905517; P:macrophage migration; IEA:Ensembl.
DR GO; GO:1990266; P:neutrophil migration; IEA:Ensembl.
DR GO; GO:0071651; P:positive regulation of chemokine (C-C motif) ligand 5 production; IEA:Ensembl.
DR GO; GO:2000343; P:positive regulation of chemokine (C-X-C motif) ligand 2 production; IEA:Ensembl.
DR GO; GO:0071642; P:positive regulation of macrophage inflammatory protein 1 alpha production; IEA:Ensembl.
DR GO; GO:0071639; P:positive regulation of monocyte chemotactic protein-1 production; IEA:Ensembl.
DR Gene3D; 1.10.287.70; -; 1.
DR InterPro; IPR049134; MCLN_ECD.
DR InterPro; IPR039031; Mucolipin.
DR InterPro; IPR013122; PKD1_2_channel.
DR PANTHER; PTHR12127; MUCOLIPIN; 1.
DR PANTHER; PTHR12127:SF4; MUCOLIPIN-2; 1.
DR Pfam; PF21381; MCLN_ECD; 2.
DR Pfam; PF08016; PKD_channel; 1.
PE 4: Predicted;
KW Cell membrane {ECO:0000256|ARBA:ARBA00022475};
KW Disulfide bond {ECO:0000256|ARBA:ARBA00023157};
KW Endosome {ECO:0000256|ARBA:ARBA00022753};
KW Ion channel {ECO:0000256|ARBA:ARBA00023303};
KW Ion transport {ECO:0000256|ARBA:ARBA00023065};
KW Membrane {ECO:0000256|ARBA:ARBA00023136, ECO:0000256|SAM:Phobius};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Transmembrane {ECO:0000256|ARBA:ARBA00022692, ECO:0000256|SAM:Phobius};
KW Transmembrane helix {ECO:0000256|ARBA:ARBA00022989,
KW ECO:0000256|SAM:Phobius}; Transport {ECO:0000256|ARBA:ARBA00022448}.
FT TRANSMEM 252..281
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 302..322
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 342..360
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 380..402
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT TRANSMEM 448..469
FT /note="Helical"
FT /evidence="ECO:0000256|SAM:Phobius"
FT DOMAIN 95..194
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 212..238
FT /note="Mucolipin extracytosolic"
FT /evidence="ECO:0000259|Pfam:PF21381"
FT DOMAIN 341..476
FT /note="Polycystin cation channel PKD1/PKD2"
FT /evidence="ECO:0000259|Pfam:PF08016"
SQ SEQUENCE 529 AA; 60467 MW; 9AECE987209B735E CRC64;
MPRGGESLDL TVWDRASGLS RGPRHRSVPL EHAAVLPPSI PVPLRPAHRL KFPGSTRCDT
HRAEDIFFPW KIVKFIFLFD FLFQLVRFGL GNQLVVAFKE DNTVAFKHLF LKGYSGIDED
DYSCSVYTQK DAYESIFFVI HQYHHLKNIS LATLDYGENE DNIIGLKICK QHYKKGTMPS
SNETLNIDSD IETGNTAMIS LCALVVFCGE SKITFDNKAH SGKIKIYFDS DSDIEECKDL
NISGSIQKNP QYVLVFDAFV IVICLASLIL CTRSVVLALR LRKRFLNFFL EKHKRRVCDA
DQWEFISGWY VLVIISDLMT IIGSILKMEI KAKNLTNYDL CSILLGTSTL FVWVGVIRYL
GYFQAYNVLI LTMQASLPKV LRFCACAGMI YLGYTFCGWI VLGPYHEKFE NLNIVAECLF
SLVNGDDMFA TFAQIQQKSI LVWLFSRLYL YSFISLFIYM ILSLFIALIT DSYDTIKKYQ
QNGFPETDLQ EFLKECSSKE ECQKESSAFL SSVCCLRRKG SDDHLILIN
//
