ID I3MHU0_ICTTR Unreviewed; 611 AA.
AC I3MHU0;
DT 11-JUL-2012, integrated into UniProtKB/TrEMBL.
DT 22-NOV-2017, sequence version 2.
DT 27-MAR-2024, entry version 58.
DE SubName: Full=RUN and FYVE domain containing 2 {ECO:0000313|Ensembl:ENSSTOP00000010486.3};
GN Name=RUFY2 {ECO:0000313|Ensembl:ENSSTOP00000010486.3};
OS Ictidomys tridecemlineatus (Thirteen-lined ground squirrel) (Spermophilus
OS tridecemlineatus).
OC Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC Eutheria; Euarchontoglires; Glires; Rodentia; Sciuromorpha; Sciuridae;
OC Xerinae; Marmotini; Ictidomys.
OX NCBI_TaxID=43179 {ECO:0000313|Ensembl:ENSSTOP00000010486.3, ECO:0000313|Proteomes:UP000005215};
RN [1] {ECO:0000313|Proteomes:UP000005215}
RP NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RG The Broad Institute Genome Assembly & Analysis Group;
RG Computational R&D Group;
RG and Sequencing Platform;
RA Di Palma F., Alfoldi J., Johnson J., Berlin A., Gnerre S., Jaffe D.,
RA MacCallum I., Young S., Walker B.J., Lindblad-Toh K.;
RT "The Draft Genome of Spermophilus tridecemlineatus.";
RL Submitted (NOV-2011) to the EMBL/GenBank/DDBJ databases.
RN [2] {ECO:0000313|Ensembl:ENSSTOP00000010486.3}
RP IDENTIFICATION.
RG Ensembl;
RL Submitted (NOV-2023) to UniProtKB.
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DR EMBL; AGTP01042606; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042607; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042608; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR EMBL; AGTP01042609; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR AlphaFoldDB; I3MHU0; -.
DR STRING; 43179.ENSSTOP00000010486; -.
DR Ensembl; ENSSTOT00000011685.3; ENSSTOP00000010486.3; ENSSTOG00000011678.3.
DR eggNOG; KOG4381; Eukaryota.
DR GeneTree; ENSGT00940000155595; -.
DR HOGENOM; CLU_014576_3_1_1; -.
DR InParanoid; I3MHU0; -.
DR TreeFam; TF323904; -.
DR Proteomes; UP000005215; Unassembled WGS sequence.
DR GO; GO:0005737; C:cytoplasm; IEA:Ensembl.
DR GO; GO:0046872; F:metal ion binding; IEA:UniProtKB-KW.
DR GO; GO:0017124; F:SH3 domain binding; IEA:Ensembl.
DR CDD; cd17695; RUN_RUFY2; 1.
DR Gene3D; 1.20.5.170; -; 1.
DR Gene3D; 1.20.58.900; -; 1.
DR Gene3D; 3.30.40.10; Zinc/RING finger domain, C3HC4 (zinc finger); 1.
DR InterPro; IPR047335; RUFY1-3.
DR InterPro; IPR004012; Run_dom.
DR InterPro; IPR037213; Run_dom_sf.
DR InterPro; IPR047332; RUN_RUFY2.
DR InterPro; IPR000306; Znf_FYVE.
DR InterPro; IPR017455; Znf_FYVE-rel.
DR InterPro; IPR011011; Znf_FYVE_PHD.
DR InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR PANTHER; PTHR45956:SF3; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2; 1.
DR PANTHER; PTHR45956; RUN AND FYVE DOMAIN-CONTAINING PROTEIN 2-LIKE PROTEIN; 1.
DR Pfam; PF01363; FYVE; 1.
DR Pfam; PF02759; RUN; 1.
DR SMART; SM00064; FYVE; 1.
DR SMART; SM00593; RUN; 1.
DR SUPFAM; SSF57903; FYVE/PHD zinc finger; 1.
DR SUPFAM; SSF140741; RUN domain-like; 1.
DR PROSITE; PS50826; RUN; 1.
DR PROSITE; PS50178; ZF_FYVE; 1.
PE 4: Predicted;
KW Coiled coil {ECO:0000256|SAM:Coils};
KW Metal-binding {ECO:0000256|ARBA:ARBA00022723};
KW Reference proteome {ECO:0000313|Proteomes:UP000005215};
KW Zinc {ECO:0000256|ARBA:ARBA00022833};
KW Zinc-finger {ECO:0000256|ARBA:ARBA00022771, ECO:0000256|PROSITE-
KW ProRule:PRU00091}.
FT DOMAIN 42..174
FT /note="RUN"
FT /evidence="ECO:0000259|PROSITE:PS50826"
FT DOMAIN 545..603
FT /note="FYVE-type"
FT /evidence="ECO:0000259|PROSITE:PS50178"
FT COILED 232..266
FT /evidence="ECO:0000256|SAM:Coils"
FT COILED 303..533
FT /evidence="ECO:0000256|SAM:Coils"
SQ SEQUENCE 611 AA; 70679 MW; 78E103E19E33D192 CRC64;
MPCKTLATKD PSAVERANLL NMAKLSIKGL IESALSFGRT LDSDYPPLQQ FFVVMEHCLK
HGLKVRKSFL SYNKTIWGPL ELVEKLYPEA EEIGASVRDL PGLKTPLGRA RAWLRLALMQ
KKMADYLRCL IIQRDLLSEF YEYHALMMEE EGAVIVGLLV GLNVIDANLC VKGEDLDSQV
GVIDFSMYLK NEEDIGNKER NVQIAAILDQ KNYVEELNRQ LNSTVSSLHS RVDSLEKSNT
KLIEELAIAK NNIIKLQEEN HQLRSENKMI LMKTQQHLEV TKVDVETELQ TYKHSRQGLD
EMYNDARRQL RDESQLRQDV ENELSVQVSM KHEIELAMKL LEKDIHEKQD TLIGLRQQLE
EVKAINIEMY RKLQGCEDGL KEKNEIIARL EEKTNKITVA MRQLEQRLQQ AEKAQMEAED
EDEKYLQECL SQSDSLQKQI SQKEKQLIQL ETDLKIEKEW RQTLQEDLQK EKDALSHLRN
ETQQITNLKK EFLNLQDENQ QLKKIYREQE QALQELGNKL SESKLKIEDI KEANKALQGL
VWLKDKEATH CKLCEKEFSL SKRKHHCRNC GEIFCNACSD NELPLPSSPK PVRVCDSCHA
LLIQRCSSNL P
//
